1. Membrane Transporter/Ion Channel
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  2. TRP Channel
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  3. Adenosine 5′-diphosphoribose sodium

Adenosine 5′-diphosphoribose sodium (Synonyms: ADP ribose sodium)

Cat. No.: HY-100973A Purity: 99.03%
Handling Instructions

Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy.

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Adenosine 5′-diphosphoribose sodium Chemical Structure

Adenosine 5′-diphosphoribose sodium Chemical Structure

CAS No. : 68414-18-6

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10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
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Description

Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy[1][2].

IC50 & Target

TRPM2 channel[1][2]
Autophagy[1]

In Vitro

In mouse embryonic fibroblasts (MEFs), H2O2 treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca2+ elevation through extracellular Ca2+ influx and (or) lysosomal Ca2+ release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress[1][1].
TRPM2 channels are activated by binding of Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus. In addition to ADPR, intracellular Ca2+ is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

581.30

Formula

C₁₅H₂₂N₅NaO₁₄P₂

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (215.04 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7203 mL 8.6014 mL 17.2028 mL
5 mM 0.3441 mL 1.7203 mL 3.4406 mL
10 mM 0.1720 mL 0.8601 mL 1.7203 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.03%

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Adenosine 5′-diphosphoribose sodium
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HY-100973A
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