Adenosine 5′-diphosphoribose sodium
Based on 9 publication(s) in Google Scholar
Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy.
For research use only. We do not sell to patients.
- Purity: 99.47%
- CAS No.: 68414-18-6
- Formula: C15H22N5NaO14P2
- Molecular Weight:581.30
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Adenosine 5′-diphosphoribose sodium
More- Signal Transduct Target Ther. 2026 Mar 26;11(1):113. [Abstract]
- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Mol Cell. 2023 Dec 21;83(24):4600-4613.e6. [Abstract]
- Cell Rep Med. 2024 Feb 20;5(2):101400. [Abstract]
- Chem Eng J. 2026 Feb 5.
- Int J Biol Macromol. 2026 May 6:152409. [Abstract]
- EMBO J. 2025 Aug;44(15):4222-4251. [Abstract]
- J Chromatogr A. 2024 Apr 26:1721:464821. [Abstract]
- Res Sq. 2026 Mar 5.
Customer Validation & Images
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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RT-PCR
Biological Activity
In mouse embryonic fibroblasts (MEFs), H2O2 treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca2+ elevation through extracellular Ca2+ influx and (or) lysosomal Ca2+ release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress[1][1].
TRPM2 channels are activated by binding of Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus. In addition to ADPR, intracellular Ca2+ is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 68414-18-6
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Appearance Solid
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Molecular Weight 581.30
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Formula C15H22N5NaO14P2
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Color White to light yellow
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SMILES
O[C@H]([C@@H]1O)[C@@H](O[C@@H]1COP(OP(OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)([O-])=O)(O)=O)N2C(N=CN=C3N)=C3N=C2.[Na+]
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Synonyms
ADP ribose sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)
Publications (9)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Short-chain acyl-CoA dehydrogenase initiates mtDNA demethylation and leakage to fuel antitumor immunity in colorectal cancer. [Abstract]2026 Mar 26;11(1):113. PMID: 41888107 -
Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Mol Cell
2023 Dec 21;83(24):4600-4613.e6. PMID: 38096825 -
Cell Rep Med
Inhibition of CD38 enzymatic activity enhances CAR-T cell immune-therapeutic efficacy by repressing glycolytic metabolism. [Abstract]2024 Feb 20;5(2):101400. PMID: 38307031 -
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Int J Biol Macromol
Molecular basis of BACE1 modulation revealed by machine learning, molecular simulations, and experimental validation. [Abstract]2026 May 6:152409. PMID: 42103119 -
EMBO J
Copine-6 is a TRPM3 escort protein controlling the sensitivity of sensory neurons to noxious heat. [Abstract]2025 Aug;44(15):4222-4251. PMID: 40537608
Adenosine 5′-diphosphoribose sodium purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Aug;44(15):4222-4251. [Abstract]
Results indicated that a minimum concentration of 5 μM was sufficient to enhance sensitivity and improve peak shape for the analytes. The sensitivity was enhanced by about 12-fold for cADPR, 40-fold for NMN, 5-fold for NAD, and 3-fold for ADPR. Analysis was performed on a mixed sample of 2ng/mL cADPR, 0.2 ng/mL NMN, 20 ng/mL NAD, and 20 ng/mL ADPR (Adenosine 5′-diphosphoribose sodium) using the Water Atlantis Premier BEH C18 AX column.
Adenosine 5′-diphosphoribose sodium purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Aug;44(15):4222-4251. [Abstract]
MRM chromatograms showing NAD+, NMN, NAM, ADPR (Adenosine 5′-diphosphoribose sodium), cADPR, and IS peaks detected using LC-MS/MS.
Adenosine 5′-diphosphoribose sodium purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Aug;44(15):4222-4251. [Abstract]
Compared to the normal nerve, a decreased NAD+ level and increased NMN level in the injured nerves were observed, resulting in about a 2-fold increase in NMN/NAD+ ratio. The level of NAM and ADPR (Adenosine 5′-diphosphoribose sodium) decreased by about 2-fold, and cADPR increased by more than 8-fold.
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J Chromatogr A
Development and validation of an LC-MS/MS method for quantifying NAD+ and related metabolites in mice sciatic nerves and its application to a nerve injury animal model. [Abstract]2024 Apr 26:1721:464821. PMID: 38547681 -
Solvent & Solubility
H2O : 125 mg/mL (215.04 mM; Need ultrasonic)
DMSO : 25 mg/mL (43.01 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (172.03 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhang DX, et al. The potential regulatory roles of NAD(+) and its metabolism in autophagy. Metabolism. 2016 Apr;65(4):454-62. [Content Brief]
[2]. Tóth B, et al. Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13440-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.7203 mL | 8.6014 mL | 17.2028 mL | 43.0071 mL |
| 5 mM | 0.3441 mL | 1.7203 mL | 3.4406 mL | 8.6014 mL | |
| 10 mM | 0.1720 mL | 0.8601 mL | 1.7203 mL | 4.3007 mL | |
| 15 mM | 0.1147 mL | 0.5734 mL | 1.1469 mL | 2.8671 mL | |
| 20 mM | 0.0860 mL | 0.4301 mL | 0.8601 mL | 2.1504 mL | |
| 25 mM | 0.0688 mL | 0.3441 mL | 0.6881 mL | 1.7203 mL | |
| 30 mM | 0.0573 mL | 0.2867 mL | 0.5734 mL | 1.4336 mL | |
| 40 mM | 0.0430 mL | 0.2150 mL | 0.4301 mL | 1.0752 mL | |
| H2O | 50 mM | 0.0344 mL | 0.1720 mL | 0.3441 mL | 0.8601 mL |
| 60 mM | 0.0287 mL | 0.1434 mL | 0.2867 mL | 0.7168 mL | |
| 80 mM | 0.0215 mL | 0.1075 mL | 0.2150 mL | 0.5376 mL | |
| 100 mM | 0.0172 mL | 0.0860 mL | 0.1720 mL | 0.4301 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Adenosine 5′-diphosphoribose sodium Related Classifications
HY-100973A Related Classifications
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