1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Autophagy
  2. TRP Channel
    Autophagy
  3. Adenosine 5′-diphosphoribose sodium

Adenosine 5′-diphosphoribose sodium (Synonyms: ADP ribose sodium)

Cat. No.: HY-100973A
Handling Instructions

Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy.

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Adenosine 5′-diphosphoribose sodium Chemical Structure

Adenosine 5′-diphosphoribose sodium Chemical Structure

CAS No. : 68414-18-6

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Description

Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy[1][2].

IC50 & Target

TRPM2 channel[1][2]
Autophagy[1]

In Vitro

In mouse embryonic fibroblasts (MEFs), H2O2 treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca2+ elevation through extracellular Ca2+ influx and (or) lysosomal Ca2+ release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress[1][1].
TRPM2 channels are activated by binding of Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus. In addition to ADPR, intracellular Ca2+ is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands[2].

Molecular Weight

581.30

Formula

C₁₅H₂₂N₅NaO₁₄P₂

CAS No.

68414-18-6

SMILES

O[[email protected]]([[email protected]@H]1O)[[email protected]@H](O[[email protected]@H]1COP(OP(OC[[email protected]@H](O)[[email protected]@H](O)[[email protected]@H](O)C=O)([O-])=O)(O)=O)N2C(N=CN=C3N)=C3N=C2.[Na+]

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Keywords:

Adenosine 5′-diphosphoriboseADP riboseTRP ChannelAutophagyTransient receptor potential channelsTRPM2Ca2+NAD+metabolitePARP-1autophagysodiumintracellularInhibitorinhibitorinhibit

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