2. Adenosine 5′-diphosphoribose sodium

Adenosine 5′-diphosphoribose sodium  (Synonyms: ADP ribose sodium)

Cat. No.: HY-100973A Purity: 99.03%
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Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy.

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Adenosine 5′-diphosphoribose sodium Chemical Structure

Adenosine 5′-diphosphoribose sodium Chemical Structure

CAS No. : 68414-18-6

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5 mg USD 77 In-stock
10 mg USD 120 In-stock
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Based on 2 publication(s) in Google Scholar

Adenosine 5′-diphosphoribose sodium Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Adenosine 5′-diphosphoribose sodium

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Description

Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy[1][2].

IC50 & Target

TRPM2 channel[1][2]
Autophagy[1]
In Vitro

In mouse embryonic fibroblasts (MEFs), H2O2 treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca2+ elevation through extracellular Ca2+ influx and (or) lysosomal Ca2+ release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress[1][1].
TRPM2 channels are activated by binding of Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus. In addition to ADPR, intracellular Ca2+ is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Adenosine 5′-diphosphoribose sodium Related Antibodies
Clinical Trial
Molecular Weight

581.30

Formula

C15H22N5NaO14P2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O[C@H]([C@@H]1O)[C@@H](O[C@@H]1COP(OP(OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)([O-])=O)(O)=O)N2C(N=CN=C3N)=C3N=C2.[Na+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (215.04 mM; Need ultrasonic)

DMSO : 25 mg/mL (43.01 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7203 mL 8.6014 mL 17.2028 mL
5 mM 0.3441 mL 1.7203 mL 3.4406 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (172.03 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.03%

COA (250 KB) HNMR (284 KB) LCMS (272 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.7203 mL 8.6014 mL 17.2028 mL 43.0071 mL
5 mM 0.3441 mL 1.7203 mL 3.4406 mL 8.6014 mL
10 mM 0.1720 mL 0.8601 mL 1.7203 mL 4.3007 mL
15 mM 0.1147 mL 0.5734 mL 1.1469 mL 2.8671 mL
20 mM 0.0860 mL 0.4301 mL 0.8601 mL 2.1504 mL
25 mM 0.0688 mL 0.3441 mL 0.6881 mL 1.7203 mL
30 mM 0.0573 mL 0.2867 mL 0.5734 mL 1.4336 mL
40 mM 0.0430 mL 0.2150 mL 0.4301 mL 1.0752 mL
H2O 50 mM 0.0344 mL 0.1720 mL 0.3441 mL 0.8601 mL
60 mM 0.0287 mL 0.1434 mL 0.2867 mL 0.7168 mL
80 mM 0.0215 mL 0.1075 mL 0.2150 mL 0.5376 mL
100 mM 0.0172 mL 0.0860 mL 0.1720 mL 0.4301 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adenosine 5′-diphosphoribose68414-18-6ADP riboseInhibitorinhibitorinhibit

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