5'-Guanylic acid
Based on 2 publication(s) in Google Scholar
5'-Guanylic acid is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid also causes neuronal cell death at high concentrations.
For research use only. We do not sell to patients.
- Purity: 99.96%
- CAS No.: 85-32-5
- Formula: C10H14N5O8P
- Molecular Weight:363.22
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) 5'-Guanylic acid
MoreAll Endogenous Metabolite Isoforms
MoreAll iGluR Isoforms
More
Biological Activity
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Human Endogenous Metabolite |
5'-Guanylic acid (50-500 μM, 48 h) regulates the expression of genes involved in fatty acid metabolism, affects fatty acid composition in Oncorhynchus mykiss hepatocytes, and regulates fatty acid metabolism[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Oncorhynchus mykiss hepatocytes
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Concentration:50-500 μM
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Incubation Time:12-48 h
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Result:Upregulated the expressions of Δ5 fads2, elovl2, elovl5 and srebp-1.
Downregulated the expression of pparα.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats models[2].
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Dosage:10-150 mg/kg
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Administration:ip, single dose
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Result:Increased the time rats spent in the light zone in the light-dark box test.
Increased the time rats spent in the open arms in the elevated plus maze test.
Chemical Information
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CAS No. 85-32-5
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Appearance Solid
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Molecular Weight 363.22
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Formula C10H14N5O8P
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Color White to off-white
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SMILES
O=P(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=C(N)NC3=O)O1)O)O)O
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Synonyms
5'-GMP; 5'-guanosine monophosphate
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Talanta
A simple, rapid and sensitive HILIC LC-MS/MS method for simultaneous determination of 16 purine metabolites in plasma and urine. [Abstract]2024 Jan 15:267:125171. PMID: 37696233 -
Noncoding RNA Res
Tongue squamous cell carcinoma-derived exosomes miR-21-5p affect tumor progression via promoting M2 macrophage polarization. [Abstract]2025 May 15:13:184-196. PMID: 40519608
Solvent & Solubility
H2O : 83.33 mg/mL (229.42 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Tansutaphanit S, et al. Impact of purine nucleotide on fatty acid metabolism and expression of lipid metabolism-related gene in the liver cell of rainbow trout Oncorhynchus mykiss. Comp Biochem Physiol B Biochem Mol Biol. 2023 Jun-Jul;266:110845. [Content Brief]
[2]. Almeida RF, et al. Systemic administration of GMP induces anxiolytic-like behavior in rats. Pharmacol Biochem Behav. 2010 Sep;96(3):306-11. [Content Brief]
[3]. Molz S, et al., Guanosine-5'-monophosphate induces cell death in rat hippocampal slices via ionotropic glutamate receptors activation and glutamate uptake inhibition. Neurochem Int. 2009 Dec;55(7):703-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.7532 mL | 13.7658 mL | 27.5315 mL | 68.8288 mL |
| 5 mM | 0.5506 mL | 2.7532 mL | 5.5063 mL | 13.7658 mL | |
| 10 mM | 0.2753 mL | 1.3766 mL | 2.7532 mL | 6.8829 mL | |
| 15 mM | 0.1835 mL | 0.9177 mL | 1.8354 mL | 4.5886 mL | |
| 20 mM | 0.1377 mL | 0.6883 mL | 1.3766 mL | 3.4414 mL | |
| 25 mM | 0.1101 mL | 0.5506 mL | 1.1013 mL | 2.7532 mL | |
| 30 mM | 0.0918 mL | 0.4589 mL | 0.9177 mL | 2.2943 mL | |
| 40 mM | 0.0688 mL | 0.3441 mL | 0.6883 mL | 1.7207 mL | |
| 50 mM | 0.0551 mL | 0.2753 mL | 0.5506 mL | 1.3766 mL | |
| 60 mM | 0.0459 mL | 0.2294 mL | 0.4589 mL | 1.1471 mL | |
| 80 mM | 0.0344 mL | 0.1721 mL | 0.3441 mL | 0.8604 mL | |
| 100 mM | 0.0275 mL | 0.1377 mL | 0.2753 mL | 0.6883 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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