5'-Guanylic acid-¹⁵N₅,d₁₂ dilithium  (Synonyms: 5'-GMP-¹⁵N₅,d₁₂ dilithium; 5'-guanosine monophosphate-¹⁵N₅,d₁₂ dilithium)

5'-Guanylic acid-¹⁵N₅,d₁₂ (5'-GMP-¹⁵N₅,d₁₂ dilithium; 5'-guanosine monophosphate-¹⁵N₅,d₁₂) dilithium is deuterium and ¹⁵N labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

392.13

C₁₀D₁₂Li₂¹⁵N₅O₈P

O=P(O[Li])(O[Li])OC([2H])([2H])[C@@]1([2H])O[C@]([15N]2C([15N]=C([15N]([2H])[2H])[15N]([2H])C3=O)=C3[15N]=C2[2H])([2H])[C@](O[2H])([2H])[C@]1([2H])O[2H]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]