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  5. Tryprostatin A

Tryprostatin A is an inhibitor of the mammalian cell cycle. Tryprostatins A can be isolated from the secondary metabolites of a marine fungal strain BM939.

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Tryprostatin A

Tryprostatin A Chemical Structure

CAS No. : 171864-80-5

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Tryprostatin A Related Antibodies

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Description

Tryprostatin A is an inhibitor of the mammalian cell cycle. Tryprostatins A can be isolated from the secondary metabolites of a marine fungal strain BM939[1].

Cellular Effect
Cell Line Type Value Description References
BT-549 GI50
79.7 μM
Compound: 1, tryprostatin A
Cytotoxicity against human BT549 cells
Cytotoxicity against human BT549 cells
[PMID: 18321710]
CCRF-CEM GI50
> 100 μM
Compound: 1, tryprostatin A
Cytotoxicity against human CCRF-CEM cells
Cytotoxicity against human CCRF-CEM cells
[PMID: 18321710]
COLO 205 GI50
> 100 μM
Compound: 1, tryprostatin A
Cytotoxicity against human COLO205 cells
Cytotoxicity against human COLO205 cells
[PMID: 18321710]
DU-145 GI50
> 100 μM
Compound: 1, tryprostatin A
Cytotoxicity against human DU145 cells
Cytotoxicity against human DU145 cells
[PMID: 18321710]
EKVX GI50
> 100 μM
Compound: 1, tryprostatin A
Cytotoxicity against human EKVX cells
Cytotoxicity against human EKVX cells
[PMID: 18321710]
HL-60 GI50
11.3 μM
Compound: 1, tryprostatin A
Cytotoxicity against human HL60 (TB) cells
Cytotoxicity against human HL60 (TB) cells
[PMID: 18321710]
HOP-92 GI50
21.2 μM
Compound: 1, tryprostatin A
Cytotoxicity against human HOP92 cells
Cytotoxicity against human HOP92 cells
[PMID: 18321710]
HepG2 IC50
> 50 μM
Compound: 3
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 38334086]
IGROV-1 GI50
90.5 μM
Compound: 1, tryprostatin A
Cytotoxicity against human IGROV1 cells
Cytotoxicity against human IGROV1 cells
[PMID: 18321710]
K562 GI50
2.73 μM
Compound: 1, tryprostatin A
Cytotoxicity against human K562 cells
Cytotoxicity against human K562 cells
[PMID: 18321710]
K562 IC50
41 μM
Compound: 13
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
[PMID: 19256529]
LOX IMVI GI50
> 100 μM
Compound: 1, tryprostatin A
Cytotoxicity against human LOX IMVI cells
Cytotoxicity against human LOX IMVI cells
[PMID: 18321710]
MCF7 GI50
> 100 μM
Compound: 1, tryprostatin A
Cytotoxicity against human MCF7 cells after 72 hrs by Cell Titer 96 Aqueous Non-Radioactive assay
Cytotoxicity against human MCF7 cells after 72 hrs by Cell Titer 96 Aqueous Non-Radioactive assay
[PMID: 18321710]
OVCAR-3 GI50
> 100 μM
Compound: 1, tryprostatin A
Cytotoxicity against human OVCAR-3 cells
Cytotoxicity against human OVCAR-3 cells
[PMID: 18321710]
PC-3 GI50
94 μM
Compound: 1, tryprostatin A
Cytotoxicity against human PC3 cells after 72 hrs by Cell Titer 96 Aqueous Non-Radioactive assay
Cytotoxicity against human PC3 cells after 72 hrs by Cell Titer 96 Aqueous Non-Radioactive assay
[PMID: 18321710]
RPMI-8226 GI50
37.1 μM
Compound: 1, tryprostatin A
Cytotoxicity against human RPMI8226 cells
Cytotoxicity against human RPMI8226 cells
[PMID: 18321710]
SR GI50
5.68 μM
Compound: 1, tryprostatin A
Cytotoxicity against human SR cells
Cytotoxicity against human SR cells
[PMID: 18321710]
UO-31 GI50
> 100 μM
Compound: 1, tryprostatin A
Cytotoxicity against human UO31 cells
Cytotoxicity against human UO31 cells
[PMID: 18321710]
Molecular Weight

381.47

Formula

C22H27N3O3
CAS No.
SMILES

O=C(N[C@H]1CC2=C(C/C=C(C)\C)NC3=C2C=CC(OC)=C3)[C@@](CCC4)([H])N4C1=O
Structure Classification
Initial Source

Aspergillus fumigatus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tryprostatin A Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tryprostatin A171864-80-5OthersNatural Products,Cell Cycle InhibitorInhibitorinhibitorinhibit

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Tryprostatin A
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