Glutaryl coenzyme A lithium
Based on 1 Customer Validation
Glutaryl coenzyme A lithium is an endogenous metabolite. Glutaryl coenzyme A lithium acts on the E2k subunit to inhibit KGDHc. It serves as a substrate for the reverse reaction of E2k and does not affect the E1k or E3 subunits of KGDHc. Glutaryl coenzyme A lithium exhibits weak inhibitory activity against citrate synthase. It can be used in research on glutaryl-CoA dehydrogenase deficiency (type I glutaric acidemia).
For research use only. We do not sell to patients.
- Purity: 99.75%
- CAS No.: 103192-48-9
- Formula: C26H40Li2N7O19P3S
- Molecular Weight:893.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Glutaryl coenzyme A (1 mmol/liter) lithium does not directly inhibit the activity of respiratory chain complexes I-V in bovine heart submitochondrial particles[1].
Glutaryl coenzyme A lithium acts as an uncompetitive inhibitor of purified porcine heart α-ketoglutarate dehydrogenase complex with respect to α-ketoglutarate, with a slope inhibitor constant (Kis) of 0.35 mmol/liter[1].
Glutaryl coenzyme A (1 mmol/liter) lithium is a substrate/product of the E2k (dihydrolipoyl succinyltransferase) subunit of porcine heart KGDHc but does not inhibit the E1k or E3 subunits[1].
Glutaryl coenzyme A (up to 2 mmol/liter) lithium inhibits purified porcine heart pyruvate dehydrogenase complex to a lesser extent than it inhibits α-ketoglutarate dehydrogenase complex[1].
Glutaryl coenzyme A (up to 2 mmol/liter) lithium has no significant direct effect on malate dehydrogenase, fumarase, aconitase, or isocitrate dehydrogenase, and only weakly inhibits citrate synthase in purified porcine heart TCA cycle enzyme preparations[1].
Glutaryl coenzyme A (up to 1 mmol/liter) lithium does not directly inhibit the activities of SCAD, MCAD, or VLCAD in mouse liver homogenates[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 103192-48-9
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Appearance Solid
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Molecular Weight 893.50
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Formula C26H40Li2N7O19P3S
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Color White to off-white
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SMILES
O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCCC(O)=O)=O)=O)=O)(O[Li])=O)(O[Li])=O)O[C@H]1N2C=NC3=C(N)N=CN=C32
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
H2O : 100 mg/mL (111.92 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.1192 mL | 5.5960 mL | 11.1919 mL | 27.9799 mL |
| 5 mM | 0.2238 mL | 1.1192 mL | 2.2384 mL | 5.5960 mL | |
| 10 mM | 0.1119 mL | 0.5596 mL | 1.1192 mL | 2.7980 mL | |
| 15 mM | 0.0746 mL | 0.3731 mL | 0.7461 mL | 1.8653 mL | |
| 20 mM | 0.0560 mL | 0.2798 mL | 0.5596 mL | 1.3990 mL | |
| 25 mM | 0.0448 mL | 0.2238 mL | 0.4477 mL | 1.1192 mL | |
| 30 mM | 0.0373 mL | 0.1865 mL | 0.3731 mL | 0.9327 mL | |
| 40 mM | 0.0280 mL | 0.1399 mL | 0.2798 mL | 0.6995 mL | |
| 50 mM | 0.0224 mL | 0.1119 mL | 0.2238 mL | 0.5596 mL | |
| 60 mM | 0.0187 mL | 0.0933 mL | 0.1865 mL | 0.4663 mL | |
| 80 mM | 0.0140 mL | 0.0699 mL | 0.1399 mL | 0.3497 mL | |
| 100 mM | 0.0112 mL | 0.0560 mL | 0.1119 mL | 0.2798 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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