Glutaryl coenzyme A lithium
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Glutaryl coenzyme A lithium is an endogenous metabolite. Glutaryl coenzyme A lithium acts on the E2k subunit to inhibit KGDHc. It serves as a substrate for the reverse reaction of E2k and does not affect the E1k or E3 subunits of KGDHc. Glutaryl coenzyme A lithium exhibits weak inhibitory activity against citrate synthase. It can be used in research on glutaryl-CoA dehydrogenase deficiency (type I glutaric acidemia).
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- Pureté : 97.59%
- CAS No.: 103192-48-9
- Formule: C26H40Li2N7O19P3S
- Masse moléculaire:893.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
Glutaryl coenzyme A (1 mmol/liter) lithium is a substrate/product of the E2k (dihydrolipoyl succinyltransferase) subunit of porcine heart KGDHc but does not inhibit the E1k or E3 subunits[1].
Glutaryl coenzyme A (up to 2 mmol/liter) lithium inhibits purified porcine heart pyruvate dehydrogenase complex to a lesser extent than it inhibits α-ketoglutarate dehydrogenase complex[1].
Glutaryl coenzyme A (up to 2 mmol/liter) lithium has no significant direct effect on malate dehydrogenase, fumarase, aconitase, or isocitrate dehydrogenase, and only weakly inhibits citrate synthase in purified porcine heart TCA cycle enzyme preparations[1].
Glutaryl coenzyme A (up to 1 mmol/liter) lithium does not directly inhibit the activities of SCAD, MCAD, or VLCAD in mouse liver homogenates[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 103192-48-9
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Appearance Solid
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Masse moléculaire 893.50
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Formule C26H40Li2N7O19P3S
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Color White to off-white
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SMILES
O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCCC(O)=O)=O)=O)=O)(O[Li])=O)(O[Li])=O)O[C@H]1N2C=NC3=C(N)N=CN=C32
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvant et solubilité
In Vitro:
H2O : 100 mg/mL (111.92 mM; Need ultrasonic)
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureté et documentation
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Fiche technique (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.1192 mL | 5.5960 mL | 11.1919 mL | 27.9799 mL |
| 5 mM | 0.2238 mL | 1.1192 mL | 2.2384 mL | 5.5960 mL | |
| 10 mM | 0.1119 mL | 0.5596 mL | 1.1192 mL | 2.7980 mL | |
| 15 mM | 0.0746 mL | 0.3731 mL | 0.7461 mL | 1.8653 mL | |
| 20 mM | 0.0560 mL | 0.2798 mL | 0.5596 mL | 1.3990 mL | |
| 25 mM | 0.0448 mL | 0.2238 mL | 0.4477 mL | 1.1192 mL | |
| 30 mM | 0.0373 mL | 0.1865 mL | 0.3731 mL | 0.9327 mL | |
| 40 mM | 0.0280 mL | 0.1399 mL | 0.2798 mL | 0.6995 mL | |
| 50 mM | 0.0224 mL | 0.1119 mL | 0.2238 mL | 0.5596 mL | |
| 60 mM | 0.0187 mL | 0.0933 mL | 0.1865 mL | 0.4663 mL | |
| 80 mM | 0.0140 mL | 0.0699 mL | 0.1399 mL | 0.3497 mL | |
| 100 mM | 0.0112 mL | 0.0560 mL | 0.1119 mL | 0.2798 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Glutaryl coenzyme A lithium Related Classifications
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