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  3. Norgestimate

Norgestimate 

Cat. No.: HY-W013172
Handling Instructions

Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive.

For research use only. We do not sell to patients.

Norgestimate Chemical Structure

Norgestimate Chemical Structure

CAS No. : 35189-28-7

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Description

Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive[1][2].

In Vitro

Norgestimate is converted to at least two active metabolites: levonorgestrel 3-oxime (deacetylated norgestimate; norelgestromin) and levonorgestrel[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

369.50

Formula

C23H31NO3

CAS No.
SMILES

C#C[[email protected]@]1(OC(C)=O)CC[[email protected]@]2([H])[[email protected]]3([H])CCC4=C/C(CC[[email protected]]4([H])[[email protected]@]3([H])CC[[email protected]]12CC)=N/O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (338.29 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7064 mL 13.5318 mL 27.0636 mL
5 mM 0.5413 mL 2.7064 mL 5.4127 mL
10 mM 0.2706 mL 1.3532 mL 2.7064 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (5.63 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.63 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.63 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: ≥99.0%

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Product Name:
Norgestimate
Cat. No.:
HY-W013172
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