1. Immunology/Inflammation
  2. Nuclear Factor of activated T Cells (NFAT)
  3. Cyclosporin D

Cyclosporin D 

Cat. No.: HY-W019721
COA Handling Instructions

Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A. Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cyclosporin D Chemical Structure

Cyclosporin D Chemical Structure

CAS No. : 63775-96-2

Size Price Stock Quantity
5 mg USD 230 In-stock
10 mg USD 370 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A[1][2]. Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc)[3].

In Vitro

Cyclosporine D inhibits Ca2+/calmodulin dependent EF-2 phosphorylation in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cyclosporine D is a potent inhibitor in vivo of phorbol ester TPA-induced biological effects in mouse skin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1216.64

Appearance

Solid

Formula

C63H113N11O12

CAS No.
Sequence

cyclo ({Aaa}-Val-{Sar}-Leu-Val-Leu-Ala-Ala-Leu-Leu-{d-Val})

Sequence Shortening

cyclo ({Aaa}-V-{Sar}-LVLAALL-{d-Val})

Structure Classification
Source

 fungus Hypoxylon Spp. 

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (20.55 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8219 mL 4.1097 mL 8.2194 mL
5 mM 0.1644 mL 0.8219 mL 1.6439 mL
10 mM 0.0822 mL 0.4110 mL 0.8219 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.05 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.46%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Cyclosporin D
Cat. No.:
HY-W019721
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