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Cyclosporin D 

Cat. No.: HY-W019721
Handling Instructions

Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A. Cyclosporin A is a potent immunosuppressant drug, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc).

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Cyclosporin D Chemical Structure

Cyclosporin D Chemical Structure

CAS No. : 63775-96-2

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Description

Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A[1][2]. Cyclosporin A is a potent immunosuppressant drug, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc)[3].

In Vitro

Cyclosporine D inhibits Ca2+/calmodulin dependent EF-2 phosphorylation in vitro[1].

In Vivo

Cyclosporine D is a potent inhibitor in vivo of phorbol ester TPA-induced biological effects in mouse skin[1].

Molecular Weight

1216.64

Formula

C₆₃H₁₁₃N₁₁O₁₂

CAS No.

63775-96-2

Sequence

cyclo ({Aaa}-Val-{Sar}-Leu-Val-Leu-Ala-Ala-Leu-Leu-{d-Val})

Sequence Shortening

cyclo ({Aaa}-V-{Sar}-LVLAALL-{d-Val})

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Cyclosporin DOthersmetaboliteimmunosuppressantTcellactivationcalcineurin-dependentNFAcphosphorylationInhibitorinhibitorinhibit

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Cyclosporin D
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