2. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
    Immunology/Inflammation
    NF-κB
    Apoptosis
  3. Calcium Channel
    Reactive Oxygen Species
    Apoptosis
    Endogenous Metabolite
  4. Urolithin C

Urolithin C 

Cat. No.: HY-135897 Purity: 99.66%
COA Handling Instructions

Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca2+ channel opener and enhances Ca2+ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation.

For research use only. We do not sell to patients.

Urolithin C Chemical Structure

Urolithin C Chemical Structure

CAS No. : 165393-06-6

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Solution
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
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ready for reconstitution
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Estimated Time of Arrival: December 31
Solid
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 300 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Urolithin C

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca2+ channel opener and enhances Ca2+ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation[1][2].

IC50 & Target

Insulin secretion[1]
L-type Ca2+ channel[1]
Reactive oxygen species (ROS)[2]
Apoptosis[2]
In Vitro

Urolithin C (20-100 μM; 1 hour; INS-1 cells) treatment enhances glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation in INS-1 β-cells[1].
Urolithin C significantly inhibits the proliferation of PC12 cells. Urolithin C treatment actively increases the lactate dehydrogenase (LDH) release and lipid peroxidation malondialdehyde (MDA), stimulates reactive oxygen species (ROS) formation and mitochondrial membrane depolarization, and caused calcium dyshomeostasis[2].
Urolithin C treatment induces apoptosis and S phase cell cycle arrest[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: INS-1 cells
Concentration: 20 μM, 100 μM
Incubation Time: 1 hour
Result: Enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation.
In Vivo

The pharmacokinetics of Urolithin C (10 mg/kg; intraperitoneal administration) in male Wistar rat (140-160 g) are studied. The half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V1/F) and the steady-state volume of distribution (Vss/F) are 0.831 L/kg and 55.6 L/kg, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

244.20

Appearance

Solid

Formula

C13H8O5
CAS No.
SMILES

O=C1C2=CC(O)=C(O)C=C2C3=CC=C(O)C=C3O1
Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (204.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0950 mL 20.4750 mL 40.9500 mL
5 mM 0.8190 mL 4.0950 mL 8.1900 mL
10 mM 0.4095 mL 2.0475 mL 4.0950 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (8.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (8.52 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.66%

COA (250 KB) HNMR (192 KB) RP-HPLC (283 KB) MS (69 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Urolithin C165393-06-6Calcium ChannelReactive Oxygen SpeciesApoptosisEndogenous MetaboliteCa2+ channelsCa channelsPolyphenolsgut-microbialmetaboliteβ-cellsglucose-dependentinsulinERK1/2ROSmitochondriaanti-diabeticInhibitorinhibitorinhibit

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