1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
    Apoptosis
  2. Calcium Channel
    Reactive Oxygen Species
    Apoptosis
    Endogenous Metabolite
  3. Urolithin C

Urolithin C 

Cat. No.: HY-135897 Purity: 99.66%
Handling Instructions

Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca2+ channel opener and enhances Ca2+ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation.

For research use only. We do not sell to patients.

Urolithin C Chemical Structure

Urolithin C Chemical Structure

CAS No. : 165393-06-6

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 300 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca2+ channel opener and enhances Ca2+ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation[1][2].

IC50 & Target

Insulin secretion[1]
L-type Ca2+ channel[1]
Reactive oxygen species (ROS)[2]
Apoptosis[2]

In Vitro

Urolithin C (20-100 μM; 1 hour; INS-1 cells) treatment enhances glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation in INS-1 β-cells[1].
Urolithin C significantly inhibits the proliferation of PC12 cells. Urolithin C treatment actively increases the lactate dehydrogenase (LDH) release and lipid peroxidation malondialdehyde (MDA), stimulates reactive oxygen species (ROS) formation and mitochondrial membrane depolarization, and caused calcium dyshomeostasis[2].
Urolithin C treatment induces apoptosis and S phase cell cycle arrest[2].

Western Blot Analysis[1]

Cell Line: INS-1 cells
Concentration: 20 μM, 100 μM
Incubation Time: 1 hour
Result: Enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation.
In Vivo

The pharmacokinetics of Urolithin C (10 mg/kg; intraperitoneal administration) in male Wistar rat (140-160 g) are studied. The half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V1/F) and the steady-state volume of distribution (Vss/F) are 0.831 L/kg and 55.6 L/kg, respectively[3].

Molecular Weight

244.20

Formula

C₁₃H₈O₅

CAS No.

165393-06-6

SMILES

O=C1C2=CC(O)=C(O)C=C2C3=CC=C(O)C=C3O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (511.88 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0950 mL 20.4750 mL 40.9500 mL
5 mM 0.8190 mL 4.0950 mL 8.1900 mL
10 mM 0.4095 mL 2.0475 mL 4.0950 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Urolithin CCalcium ChannelReactive Oxygen SpeciesApoptosisEndogenous MetaboliteCa2+ channelsCa channelsPolyphenolsgut-microbialmetaboliteβ-cellsglucose-dependentinsulinERK1/2ROSmitochondriaanti-diabeticInhibitorinhibitorinhibit

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Urolithin C
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HY-135897
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