2. NF-κB MAPK/ERK Pathway Stem Cell/Wnt PI3K/Akt/mTOR Epigenetics Metabolic Enzyme/Protease
  3. NF-κB JNK ERK Akt AMPK Endogenous Metabolite
  4. Urolithin B

Urolithin B 

Cat. No.: HY-126307 Purity: 99.92%
COA Handling Instructions

Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass.

For research use only. We do not sell to patients.

Urolithin B Chemical Structure

Urolithin B Chemical Structure

CAS No. : 1139-83-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 55 In-stock
Solid
5 mg USD 32 In-stock
10 mg USD 50 In-stock
50 mg USD 150 In-stock
100 mg USD 250 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Urolithin B Related Antibodies

Top Publications Citing Use of Products

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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JNK1 JNK2 JNK3 JNK

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ERK ERK1 ERK2 ERK5 ERK8

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Akt Akt1 Akt2 Akt3

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

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Description

Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass[1][2].

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

212.20

Appearance

Solid

Formula

C13H8O3
CAS No.
SMILES

O=C1C2=CC=CC=C2C3=CC=C(O)C=C3O1
Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1178.13 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7125 mL 23.5627 mL 47.1254 mL
5 mM 0.9425 mL 4.7125 mL 9.4251 mL
10 mM 0.4713 mL 2.3563 mL 4.7125 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (9.80 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Urolithin B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Urolithin B1139-83-9NF-κBJNKERKAktAMPKEndogenous MetaboliteNuclear factor-κBNuclear factor-kappaBc-Jun N-terminal kinaseExtracellular signal regulated kinasesPKBProtein kinase BAMP-activated protein kinaseInhibitorinhibitorinhibit

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