2. Anti-infection MAPK/ERK Pathway Protein Tyrosine Kinase/RTK JAK/STAT Signaling PI3K/Akt/mTOR Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Apoptosis
  3. Influenza Virus p38 MAPK EGFR Akt Reactive Oxygen Species (ROS) Apoptosis
  4. Urolithin M5

Urolithin M5  (Synonyms: Decarboxyellagic acid)

Cat. No.: HY-N7922 Purity: 97.31%
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Urolithin M5 (Decarboxyellagic acid) is an orally active influenza virus neuraminidase inhibitor and neuroprotective agent, with IC50 values of 174.8 μM (HK68), 191.5 μM (pdm09), 243.2 μM (WSN) and 257.1 μM (PR8) against four influenza virus neuraminidases, respectively. Urolithin M5 inhibits viral neuraminidase activity, thereby blocking influenza virus replication (including oseltamivir (HY-13317)-resistant strains), protecting infected mammals from death and improving pulmonary edema. Urolithin M5 forms a hydrogen-bond stabilized complex with IGF1R, and binds to MAPK14, AKT1, NFKB1 and EGFR. Urolithin M5 reduces reactive oxygen species production, inhibits neuronal apoptosis, restores mitochondrial transmembrane potential, and promotes neurite outgrowth of damaged neuronal cells. Urolithin M5 can be used in research related to influenza virus infection and Alzheimer's disease.

For research use only. We do not sell to patients.

Urolithin M5

Urolithin M5 Chemical Structure

CAS No. : 91485-02-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

Urolithin M5 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Urolithin M5

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  • Biological Activity

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  • Customer Review

Description

Urolithin M5 (Decarboxyellagic acid) is an orally active influenza virus neuraminidase inhibitor and neuroprotective agent, with IC50 values of 174.8 μM (HK68), 191.5 μM (pdm09), 243.2 μM (WSN) and 257.1 μM (PR8) against four influenza virus neuraminidases, respectively. Urolithin M5 inhibits viral neuraminidase activity, thereby blocking influenza virus replication (including oseltamivir (HY-13317)-resistant strains), protecting infected mammals from death and improving pulmonary edema. Urolithin M5 forms a hydrogen-bond stabilized complex with IGF1R, and binds to MAPK14, AKT1, NFKB1 and EGFR. Urolithin M5 reduces reactive oxygen species production, inhibits neuronal apoptosis, restores mitochondrial transmembrane potential, and promotes neurite outgrowth of damaged neuronal cells. Urolithin M5 can be used in research related to influenza virus infection and Alzheimer's disease[1][2].

In Vitro

Urolithin M5 (two-fold dilution series; 48 h) exhibits cytotoxicity against MDCK cells with a CC50 of 227.4 μM[1].
Urolithin M5 (5-500 μM; 30 min virus pre-incubation, 30 min erythrocyte incubation) does not inhibit hemagglutination induced by influenza A/WSN/33(H1N1) virus in chicken erythrocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Urolithin M5 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Madin-Darby canine kidney (MDCK) cells
Concentration: 10 μM, 100 μM, 1 mM
Incubation Time: 48 h
Result: Exhibited a CC50 value of 227.4 μM against madin-Darby canine kidney (MDCK) cells.
In Vivo

Urolithin M5 (200 mg/kg/day; p.o.; once daily; 6 consecutive days) protects 50% of PR8-infected BALB/c mice from death, reduces lung edema and viral load, and lowers pro-inflammatory cytokine levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (female, 16-18 g, intranasally infected with influenza A virus strain PR8)[1]
Dosage: 200 mg/kg/day
Administration: p.o.; once daily; 6 consecutive days
Result: Protected 50% of mice from death.
Showed rebound in body weight starting at day 9.Reduced lung index from 1.445 to 0.8875.\n
Reduced lung viral titer by 0.52 log.Decreased lung tissue levels of NF-κB, TNF-α, and IL-6.
Alleviated histopathological lung lesions including reduced bronchial injury and inflammatory cell infiltration.
Molecular Weight

276.20

Formula

C13H8O7
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C1C2=CC(O)=C(O)C(O)=C2C3=CC=C(O)C(O)=C3O1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (362.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6206 mL 18.1028 mL 36.2056 mL
5 mM 0.7241 mL 3.6206 mL 7.2411 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.31%

SDS (251 KB)

COA (253 KB) HNMR (103 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6206 mL 18.1028 mL 36.2056 mL 90.5141 mL
5 mM 0.7241 mL 3.6206 mL 7.2411 mL 18.1028 mL
10 mM 0.3621 mL 1.8103 mL 3.6206 mL 9.0514 mL
15 mM 0.2414 mL 1.2069 mL 2.4137 mL 6.0343 mL
20 mM 0.1810 mL 0.9051 mL 1.8103 mL 4.5257 mL
25 mM 0.1448 mL 0.7241 mL 1.4482 mL 3.6206 mL
30 mM 0.1207 mL 0.6034 mL 1.2069 mL 3.0171 mL
40 mM 0.0905 mL 0.4526 mL 0.9051 mL 2.2629 mL
50 mM 0.0724 mL 0.3621 mL 0.7241 mL 1.8103 mL
60 mM 0.0603 mL 0.3017 mL 0.6034 mL 1.5086 mL
80 mM 0.0453 mL 0.2263 mL 0.4526 mL 1.1314 mL
100 mM 0.0362 mL 0.1810 mL 0.3621 mL 0.9051 mL
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Urolithin M5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Urolithin M591485-02-8Decarboxyellagic acidUrolithin M 5Urolithin M-5Influenza Virusp38 MAPKEGFRAktReactive Oxygen Species (ROS)ApoptosisEpidermal growth factor receptorErbB-1HER1PKBProtein kinase Boseltamivir-resistant strainsNFKB1MDCK cells*Canarium album* (Lour.) DC.influenza virus neuraminidaseIGF1RAKT1influenza virus replicationMAPK14Inhibitorinhibitorinhibit

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