Ambroxol (acefylline) (Synonyms: NA-872 (acefylline); Acebrophylline)

Cat. No.: HY-B1039C: FAQs
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Ambroxol (NA-872) acefylline, an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol acefylline is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol acefylline induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.

For research use only. We do not sell to patients.

Ambroxol (acefylline) Chemical Structure

CAS No. : 96989-76-3

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Other In-stock Forms of Ambroxol (acefylline):

Ambroxol Ambroxol hydrochloride

Other Forms of Ambroxol (acefylline):

Ambroxol In-stock
Ambroxol hydrochloride In-stock

2 Publications Citing Use of MCE Ambroxol (acefylline)

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Description	Ambroxol (NA-872) acefylline, an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol acefylline is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol acefylline induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research^[1]^[2].
Molecular Weight	616.30
Formula	C₂₂H₂₈Br₂N₆O₅
CAS No.	96989-76-3
SMILES	OC(CN1C2=C(N=C1)N(C(N(C2=O)C)=O)C)=O.O[C@H](CC3)CC[C@@H]3NCC4=C(C(Br)=CC(Br)=C4)N
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15(3):213-218. [Content Brief] [2]. Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80(5):766-775. [Content Brief]

Ambroxol (acefylline) Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ambroxol (acefylline)96989-76-3NA-872 (acefylline) AcebrophyllineGlucosidaseAutophagyBromhexineexpectorantglucocerebrosidaseGCasechaperoneParkinsonneuronopathicGaucherdiseaseInhibitorinhibitorinhibit

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Ambroxol (acefylline) (Synonyms: NA-872 (acefylline); Acebrophylline)

Other Forms of Ambroxol (acefylline):

Ambroxol (acefylline) Related Antibodies

2 Publications Citing Use of MCE Ambroxol (acefylline)

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review