Ambroxol acefylline
Based on 3 publication(s) in Google Scholar
Ambroxol (NA-872) acefylline, an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol acefylline is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol acefylline induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.
For research use only. We do not sell to patients.
- CAS No.: 96989-76-3
- Formula: C22H28Br2N6O5
- Molecular Weight:616.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Ambroxol acefylline
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Biological Activity
Chemical Information
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CAS No. 96989-76-3
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Molecular Weight 616.30
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Formula C22H28Br2N6O5
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SMILES
OC(CN1C2=C(N=C1)N(C(N(C2=O)C)=O)C)=O.O[C@H](CC3)CC[C@@H]3NCC4=C(C(Br)=CC(Br)=C4)N
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Synonyms
NA-872 acefylline; Acebrophylline
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Cell Rep
TRESK channel contributes to depolarization-induced shunting inhibition and modulates epileptic seizures. [Abstract]2021 Jul 20;36(3):109404. PMID: 34289346 -
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Evid Based Complement Alternat Med
Reineckia carnea Alleviates the Production of Inflammatory Cytokines and MUC5AC in Rats with Chronic Obstructive Pulmonary Disease. [Abstract]2022 Jun 16:2022:2135487. PMID: 35754687
Purity & Documentation
References
[1]. Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15(3):213-218. [Content Brief]
[2]. Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80(5):766-775. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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