1. Metabolic Enzyme/Protease
    Autophagy
  2. Glucosidase
    Autophagy
  3. Ambroxol hydrochloride

Ambroxol hydrochloride (Synonyms: NA-872 hydrochloride)

Cat. No.: HY-B1039A Purity: >98.0%
Handling Instructions

Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the prodrug Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.

For research use only. We do not sell to patients.

Ambroxol hydrochloride Chemical Structure

Ambroxol hydrochloride Chemical Structure

CAS No. : 23828-92-4

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10 mM * 1  mL in Water USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Ambroxol hydrochloride:

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Description

Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the prodrug Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2].

In Vivo

Ambroxol hydrochloride (NA-872 hydrochloride; 1, 3, 4, 5 mM for 12 consecutive days in drinking water) results in increased brain glucocerebrosidase activity in wild-type mice, transgenic mice expressing the heterozygous L444P mutation in the murine glucocerebrosidase 1 gene, and transgenic mice overexpressing human α-synuclein[2].

Molecular Weight

414.56

Formula

C₁₃H₁₉Br₂ClN₂O

CAS No.

23828-92-4

SMILES

O[[email protected]]1CC[[email protected]](NCC2=CC(Br)=CC(Br)=C2N)CC1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 8.33 mg/mL (20.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4122 mL 12.0610 mL 24.1220 mL
5 mM 0.4824 mL 2.4122 mL 4.8244 mL
10 mM 0.2412 mL 1.2061 mL 2.4122 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

AmbroxolNA-872NA872NA 872GlucosidaseAutophagyBromhexineexpectorantglucocerebrosidaseGCasechaperoneParkinsonneuronopathicGaucherdiseaseInhibitorinhibitorinhibit

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Product Name:
Ambroxol hydrochloride
Cat. No.:
HY-B1039A
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