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  3. Oxyphenbutazone

Oxyphenbutazone 

Cat. No.: HY-B1355A
Handling Instructions

Oxyphenbutazone is a phenylbutazone derivative, with anti-inflammatory effect. Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis.

For research use only. We do not sell to patients.

Oxyphenbutazone Chemical Structure

Oxyphenbutazone Chemical Structure

CAS No. : 129-20-4

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Description

Oxyphenbutazone is a phenylbutazone derivative, with anti-inflammatory effect. Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis[1][2].

IC50 & Target

COX[1]

In Vitro

Oxyphenbutazone enhances the anticancer efficiency of methotrexate (MTX) in Hep3B cells[1].
Oxyphenbutazone (2.5 -7.5 µM; 48 hours) co-treatment with (MTX, 0.25-1.0 µM) shows potential cytotoxicity against Hep3B cells[1].
Oxyphenbutazone exhibits reparative effects in the hepatocytes[1].

Cell Cytotoxicity Assay[1]

Cell Line: Hep3B cells
Concentration: 2.5 µM, 5 µM, 7.5 µM
Incubation Time: 48 hours
Result: Enhanced the cytotoxicity of MTX.
In Vivo

Oxyphenbutazone (70 mg/kg/week; p.o.; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.)[1].

Animal Model: 5–6 weeks Wistar strain albino male rats (150–220 g)[1]
Dosage: 70 mg/kg/week (co-treatment with MTX 5.0 or 2.5 mg/kg/week)
Administration: Oral administration; once a week; in two divided doses; for 13 weeks
Result: Exerted potential anticancer activity in rats when co-treatment with MTX.
Molecular Weight

324.37

Formula

C₁₉H₂₀N₂O₃

CAS No.

129-20-4

SMILES

O=C(C1CCCC)N(C2=CC=CC=C2)N(C3=CC=C(O)C=C3)C1=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

OxyphenbutazoneCOXBacterialCyclooxygenaseNonsteroidalanti-inflammatorydrugNSAIDmycobactericidalInhibitorinhibitorinhibit

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