2. Anti-infection Immunology/Inflammation
  3. Bacterial COX
  4. Oxyphenbutazone monohydrate

Oxyphenbutazone monohydrate is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone monohydrate is an orally active non-selective COX inhibitor. Oxyphenbutazone monohydrate selectively kills non-replicating Mycobaterium tuberculosis.

For research use only. We do not sell to patients.

Oxyphenbutazone monohydrate Chemical Structure

Oxyphenbutazone monohydrate Chemical Structure

CAS No. : 7081-38-1

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Oxyphenbutazone monohydrate Related Antibodies

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Description

Oxyphenbutazone monohydrate is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone monohydrate is an orally active non-selective COX inhibitor. Oxyphenbutazone monohydrate selectively kills non-replicating Mycobaterium tuberculosis[1][2].

IC50 & Target

COX, Bacteria[1][2]
In Vitro

Oxyphenbutazone enhances the anticancer efficiency of Methotrexate (MTX) (HY-14519) in Hep3B cells[1].
Oxyphenbutazone (2.5-7.5 µM; 48 hours) co-treatment with (MTX, 0.25-1.0 µM) shows potential cytotoxicity against Hep3B cells[1].
Oxyphenbutazone exhibits reparative effects in the hepatocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oxyphenbutazone monohydrate Related Antibodies

Cell Viability Assay[1]

Cell Line: Hep3B cells
Concentration: 2.5 µM, 5 µM, 7.5 µM
Incubation Time: 48 hours
Result: Enhanced the cytotoxicity of MTX.
In Vivo

Oxyphenbutazone (70 mg/kg/week; p.o.; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar strain albino male rats (5-6 weeks; 150-220 g)[1]
Dosage: 70 mg/kg/week (co-treatment with MTX 5.0 or 2.5 mg/kg/week)
Administration: PO; once a week; in two divided doses; for 13 weeks
Result: Exerted potential anticancer activity in rats when co-treatment with MTX.
Molecular Weight

342.39

Formula

C19H22N2O4
CAS No.
SMILES

O=C(C1CCCC)N(C2=CC=CC=C2)N(C3=CC=C(O)C=C3)C1=O.O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Oxyphenbutazone monohydrate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxyphenbutazone7081-38-1BacterialCOXCyclooxygenasePhenylbutazoneanti-inflammatoryorally activeMycobaterium tuberculosisInhibitorinhibitorinhibit

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