1. Autophagy
    Metabolic Enzyme/Protease
  2. Autophagy
    Cathepsin
  3. Asperphenamate

Asperphenamate 

Cat. No.: HY-129578 Purity: ≥98.0%
Handling Instructions

Asperphenamate, a fungal metabolite of Aspergillus flatiipes with anti-cancer effect, exhibits IC50 values of 92.3 μM, 96.5 μM and 97.9 μM in T47D, MDA-MB-231 and HL-60 cells, respectively.

For research use only. We do not sell to patients.

Asperphenamate Chemical Structure

Asperphenamate Chemical Structure

CAS No. : 63631-36-7

Size Price Stock Quantity
5 mg USD 580 In-stock
Estimated Time of Arrival: December 31
10 mg USD 800 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Asperphenamate, a fungal metabolite of Aspergillus flatiipes with anti-cancer effect, exhibits IC50 values of 92.3 μM, 96.5 μM and 97.9 μM in T47D, MDA-MB-231 and HL-60 cells, respectively[1][2].

In Vitro

Asperphenamate can inhibit cancer cell proliferation by fully inducing autophagy. asperphenamate showed inhibition effects against cathepsin L. At the same time, it also displayed weak inhibitory ability against cathepsin S.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

506.59

Formula

C₃₂H₃₀N₂O₄

CAS No.

63631-36-7

SMILES

O=C(OC[[email protected]@H](NC(C1=CC=CC=C1)=O)CC2=CC=CC=C2)[[email protected]](CC3=CC=CC=C3)NC(C4=CC=CC=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (197.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9740 mL 9.8699 mL 19.7398 mL
5 mM 0.3948 mL 1.9740 mL 3.9480 mL
10 mM 0.1974 mL 0.9870 mL 1.9740 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.93 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AsperphenamateAutophagyCathepsinbreastcancerInhibitorinhibitorinhibit

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Product Name:
Asperphenamate
Cat. No.:
HY-129578
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