2. Autophagy
    Metabolic Enzyme/Protease
  3. Autophagy
    Cathepsin
  4. Asperphenamate

Asperphenamate 

Cat. No.: HY-129578 Purity: ≥98.0%
COA Handling Instructions

Asperphenamate, a fungal metabolite of Aspergillus flatiipes with anti-cancer effect, exhibits IC50 values of 92.3 μM, 96.5 μM and 97.9 μM in T47D, MDA-MB-231 and HL-60 cells, respectively.

For research use only. We do not sell to patients.

Asperphenamate Chemical Structure

Asperphenamate Chemical Structure

CAS No. : 63631-36-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 638 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 638 In-stock
Solid
5 mg USD 580 In-stock
10 mg USD 800 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

Asperphenamate, a fungal metabolite of Aspergillus flatiipes with anti-cancer effect, exhibits IC50 values of 92.3 μM, 96.5 μM and 97.9 μM in T47D, MDA-MB-231 and HL-60 cells, respectively[1][2].

In Vitro

Asperphenamate can inhibit cancer cell proliferation by fully inducing autophagy. asperphenamate showed inhibition effects against cathepsin L. At the same time, it also displayed weak inhibitory ability against cathepsin S.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

506.59

Appearance

Solid

Formula

C32H30N2O4
CAS No.
SMILES

O=C(OC[[email protected]@H](NC(C1=CC=CC=C1)=O)CC2=CC=CC=C2)[[email protected]](CC3=CC=CC=C3)NC(C4=CC=CC=C4)=O
Structure Classification
Source

Aspergillus flavipes
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (197.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9740 mL 9.8699 mL 19.7398 mL
5 mM 0.3948 mL 1.9740 mL 3.9480 mL
10 mM 0.1974 mL 0.9870 mL 1.9740 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.93 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Asperphenamate63631-36-7AutophagyCathepsinbreastcancerInhibitorinhibitorinhibit

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