(Rac)-3′-Hydroxy simvastatin
(Rac)-3′-Hydroxy simvastatin is an isomer of 3′-Hydroxy simvastatin. 3′-Hydroxy simvastatin is an oxidative metabolite of Simvastatin (HY-17502) produced by hepatic CYP450 metabolism, and is also the major terminal metabolite of Simvastatin in rats. 3′-Hydroxy simvastatin possesses HMG-CoA Reductase inhibitory activity. 3′-Hydroxy simvastatin is used in metabolism-related research.
For research use only. We do not sell to patients.
- CAS No.: 126313-98-2
- Formula: C25H38O6
- Molecular Weight:434.57
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Biological Activity
Description
In Vitro
(Rac)-3′-Hydroxy simvastatin is an isomer of 3′-Hydroxy simvastatin. 3′-Hydroxy simvastatin is generated from Simvastatin (HY-17502) via cytochrome P450-dependent oxidative metabolism in rat liver microsomes[1].
(Rac)-3′-Hydroxy simvastatin is an isomer of 3′-Hydroxy simvastatin. 3′-Hydroxy simvastatin exhibits 20% of the HMG-CoA reductase inhibitory potency of Simvastatin acid (HY-119695)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 126313-98-2
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Appearance Solid
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Molecular Weight 434.57
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Formula C25H38O6
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Color White to off-white
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SMILES
CC(O)C(C)(C)C(OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(O3)=O)C12)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (284 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)