11,12-DiHETrE
11,12-DiHETrE is a dihydroxy fatty acid metabolite of Arachidonic Acid (HY-109590). 11,12-DiHETrE is converted to 11,12-DiHETrE under elevated soluble epoxide hydrolase (sEH) activity, a process closely related to inflammation and oxidative stress. 11,12-DiHETrE can serve as a single biomarker to differentiate between NAFL (non-alcoholic fatty liver disease) and NASH (non-alcoholic steatohepatitis). 11,12-DiHETrE can be used in studies on preterm birth, autism, and pulmonary hypertension.
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- CAS. Nr.: 192461-95-3
- Formel: C20H34O4
- Molecular Weight:338.48
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
In Vitro
11,12-DiHETrE can serve as a pharmacodynamic biomarker for soluble epoxide hydrolase (sEH) inhibitors: its levels decrease after administration of sEH inhibitors[1].
11,12-DiHETrE concentrations in plasma of patients with non-alcoholic steatohepatitis (NASH) are significantly higher than those in patients with non-alcoholic fatty liver (NAFL) and healthy controls[2].
11,12-DiHETrE is significantly positively correlated with the presence of resting pulmonary arterial hypertension[3].
The higher the exposure level of 11,12-DiHETrE in umbilical cord blood, the more likely it is for individuals to present with severe autism spectrum disorder (ASD) symptoms[4].
Elevated levels of 11,12-DiHETrE reflect an imbalance in the pro-resolving/anti-inflammatory pathway[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 192461-95-3
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Molecular Weight 338.48
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Formel C20H34O4
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SMILES
CCCCC/C=C\CC(O)C(O)C/C=C\C/C=C\CCCC(O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Svenvik M, et al. Plasma oxylipin levels associated with preterm birth in preterm labor. Prostaglandins Leukot Essent Fatty Acids. 2021 Mar;166:102251. [Content Brief]
[2]. Loomba R, et al. Polyunsaturated fatty acid metabolites as novel lipidomic biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis. J Lipid Res. 2015 Jan;56(1):185-92. [Content Brief]
[3]. McNeill JN,et al. The association of eicosanoids and eicosanoid-related metabolites with pulmonary hypertension. Eur Respir J. 2023 Oct 19;62(4):2300561. [Content Brief]
[4]. Hirai T, et al. Arachidonic acid-derived dihydroxy fatty acids in neonatal cord blood relate symptoms of autism spectrum disorders and social adaptive functioning: Hamamatsu Birth Cohort for Mothers and Children (HBC Study). Psychiatry Clin Neurosci. 2024 Sep;78(9):546-557. [Content Brief]
[5]. Sala-Climent M, et al. Oxylipin serum profile changes in response to an open-label anti-inflammatory dietary intervention. Clin Nutr ESPEN. 2025 Aug;68:389-402. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
11,12-DiHETrE Related Classifications
HY-113111 Related Classifications
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