192461-95-3
Chemical Structure
11,12-DiHETrE
- CAS No.: 192461-95-3
- Formula:C20H34O4
- Molecular Weight:338.48
IUPAC Name: (5Z,8Z,14Z)-11,12-dihydroxyicosa-5,8,14-trienoic acid
InChIKey: LRPPQRCHCPFBPE-KROJNAHFSA-N
SMILES: CCCCC/C=C\CC(O)C(O)C/C=C\C/C=C\CCCC(O)=O
Biological Activity: 11,12-DiHETrE is a dihydroxy fatty acid metabolite of Arachidonic Acid (HY-109590). 11,12-DiHETrE is converted to 11,12-DiHETrE under elevated soluble epoxide hydrolase (sEH) activity, a process closely related to inflammation and oxidative stress. 11,12-DiHETrE can serve as a single biomarker to differentiate between NAFL (non-alcoholic fatty liver disease) and NASH (non-alcoholic steatohepatitis). 11,12-DiHETrE can be used in studies on preterm birth, autism, and pulmonary hypertension[1][2][3][4][5].
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11,12-DiHETrE | 11,12-DiHETrE is a dihydroxy fatty acid metabolite of Arachidonic Acid (HY-109590). 11,12-DiHETrE is converted to 11,12-DiHETrE under elevated soluble epoxide hydrolase (sEH) activity, a process closely related to inflammation and oxidative stress. 11,12-DiHETrE can serve as a single biomarker to differentiate between NAFL (non-alcoholic fatty liver disease) and NASH (non-alcoholic steatohepatitis). 11,12-DiHETrE can be used in studies on preterm birth, autism, and pulmonary hypertension. | |||||||||||||||||||||
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11,12-DiHETrE-d11 | 99.90% | 11,12-DiHETrE-d11 is the deuterium labeled 11,12-DiHETrE. | ||||||||||||||||||||
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References
- [1]. Svenvik M, et al. Plasma oxylipin levels associated with preterm birth in preterm labor. Prostaglandins Leukot Essent Fatty Acids. 2021 Mar;166:102251. [Content Brief]
- [2]. Loomba R, et al. Polyunsaturated fatty acid metabolites as novel lipidomic biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis. J Lipid Res. 2015 Jan;56(1):185-92. [Content Brief]
- [3]. McNeill JN,et al. The association of eicosanoids and eicosanoid-related metabolites with pulmonary hypertension. Eur Respir J. 2023 Oct 19;62(4):2300561. [Content Brief]
- [4]. Hirai T, et al. Arachidonic acid-derived dihydroxy fatty acids in neonatal cord blood relate symptoms of autism spectrum disorders and social adaptive functioning: Hamamatsu Birth Cohort for Mothers and Children (HBC Study). Psychiatry Clin Neurosci. 2024 Sep;78(9):546-557. [Content Brief]
- [5]. Sala-Climent M, et al. Oxylipin serum profile changes in response to an open-label anti-inflammatory dietary intervention. Clin Nutr ESPEN. 2025 Aug;68:389-402. [Content Brief]
