Imidazol-1-yl-acetic acid
Based on 1 Customer Validation
Imidazol-1-yl-acetic acid is a BRS-3 agonist that mediates anorectic effects through activation of orphan G protein-coupled receptors (Orphan GPCR) in peripheral tissues; it also serves as a green, water-soluble, recyclable bifunctional organocatalyst for transformations such as Biginelli multicomponent reactions and epoxide ring opening. Imidazol-1-yl-acetic acid is used in the study of obesity.
For research use only. We do not sell to patients.
- Purity : 99.91%
- CAS No.: 22884-10-2
- Formula: C5H6N2O2
- Molecular Weight:126.11
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-W010448R
Imidazol-1-yl-acetic acid (Standard) -
HY-W045271
Imidazole-5-propionic acid -
HY-W007321
1H-Imidazole-2-carbaldehyde -
HY-W007695
1H-Imidazole-4-carboxylic acid -
HY-41461A
5-Amino-3H-imidazole-4-carboxamide hydrochloride -
HY-W015947
1,2-Dimethylimidazole -
HY-W009253
Lophine -
HY-W045271R
Imidazole-5-propionic acid (Standard) -
HY-41461AR
5-Amino-3H-imidazole-4-carboxamide hydrochloride (Standard)
Biological Activity
Description
In Vitro
Imidazol-1-ylacetic acid derivatives act as BRS-3 agonists, among which 2c exhibits the highest potency (human EC50 = 1 nM, mouse EC50 = 3 nM)[1].
For imidazol-1-ylacetic acid derivatives, the acetic acid group on the more sterically hindered nitrogen atom (compound 8) is more favorable for BRS-3 agonist activity than the acetic acid group on the less sterically hindered nitrogen atom (compound 9)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 22884-10-2
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Appearance Solid
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Molecular Weight 126.11
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Formula C5H6N2O2
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Color White to off-white
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SMILES
O=C(O)CN1C=CN=C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 2 mg/mL (15.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (614 KB)
- English - EN (614 KB)
- Français - FR (614 KB)
- Deutsch - DE (614 KB)
- Norwegian - NO (614 KB)
- Español - ES (614 KB)
- Swedish - SV (614 KB)
- Italian - IT (614 KB)
- Korean - KR (614 KB)
- Portuguese - PT (614 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.9296 mL | 39.6479 mL | 79.2959 mL | 198.2396 mL |
| 5 mM | 1.5859 mL | 7.9296 mL | 15.8592 mL | 39.6479 mL | |
| 10 mM | 0.7930 mL | 3.9648 mL | 7.9296 mL | 19.8240 mL | |
| 15 mM | 0.5286 mL | 2.6432 mL | 5.2864 mL | 13.2160 mL |
Imidazol-1-yl-acetic acid Related Classifications
HY-W010448 Related Classifications
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