2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Endogenous Metabolite DNA/RNA Synthesis
  4. Thymidine-5'-monophosphate disodium salt

Thymidine-5'-monophosphate disodium salt  (Synonyms: TMP disodium salt)

Cat. No.: HY-128738 Purity: 99.52%
COA
SDS
Handling Instructions Technical Support

Thymidine-5'-monophosphate (TMP) disodium salt is a key nucleotide in pyrimidine metabolism, and its kinase activity can be competitively inhibited by 5'-fluorothymidine. The level of Thymidine-5'-monophosphate disodium salt is closely associated with acute kidney injury.

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Thymidine-5'-monophosphate disodium salt

Thymidine-5'-monophosphate disodium salt 화학구조

CAS No. : 33430-62-5

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in Water 해외재고보유
Solid
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of Thymidine-5'-monophosphate disodium salt:

Thymidine-5'-monophosphate disodium salt Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Thymidine-5'-monophosphate disodium salt

View All Endogenous Metabolite Isoform Specific Products:

View All Isoforms
Human Endogenous Metabolite Microbial Metabolite

View All DNA/RNA Synthesis Isoform Specific Products:

View All Isoforms
RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Thymidine-5'-monophosphate (TMP) disodium salt is a key nucleotide in pyrimidine metabolism, and its kinase activity can be competitively inhibited by 5'-fluorothymidine. The level of Thymidine-5'-monophosphate disodium salt is closely associated with acute kidney injury[1][2].

IC50 & Target

Human Endogenous Metabolite

 

Microbial Metabolite

 

In Vitro

Thymidine-5'-monophosphate disodium salt is available for DNA synthesis as a deoxynucleotide monomer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thymidine-5'-monophosphate disodium salt Related Antibodies
분자량

366.17

화학식

C10H13N2Na2O8P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1C[C@H](N2C=C(C)C(NC2=O)=O)O[C@@H]1COP(O[Na])(O[Na])=O
Structure Classification
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도
In Vitro: 

H2O : 100 mg/mL (273.10 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7310 mL 13.6549 mL 27.3097 mL
5 mM 0.5462 mL 2.7310 mL 5.4619 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (273.10 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
순도&문서

Purity: 99.52%

SDS (393 KB)

COA (254 KB) HNMR (272 KB) RP-HPLC (277 KB) MS (177 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.7310 mL 13.6549 mL 27.3097 mL 68.2743 mL
5 mM 0.5462 mL 2.7310 mL 5.4619 mL 13.6549 mL
10 mM 0.2731 mL 1.3655 mL 2.7310 mL 6.8274 mL
15 mM 0.1821 mL 0.9103 mL 1.8206 mL 4.5516 mL
20 mM 0.1365 mL 0.6827 mL 1.3655 mL 3.4137 mL
25 mM 0.1092 mL 0.5462 mL 1.0924 mL 2.7310 mL
30 mM 0.0910 mL 0.4552 mL 0.9103 mL 2.2758 mL
40 mM 0.0683 mL 0.3414 mL 0.6827 mL 1.7069 mL
50 mM 0.0546 mL 0.2731 mL 0.5462 mL 1.3655 mL
60 mM 0.0455 mL 0.2276 mL 0.4552 mL 1.1379 mL
80 mM 0.0341 mL 0.1707 mL 0.3414 mL 0.8534 mL
100 mM 0.0273 mL 0.1365 mL 0.2731 mL 0.6827 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Thymidine-5'-monophosphate disodium salt Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thymidine-5'-monophosphate disodium33430-62-5TMP disodiumEndogenous MetaboliteDNA/RNA Synthesisthymidine-5'-monophosphate kinaseehrlich ascites carcinomaEhrlich ascites carcinoma cell-free extractsEhrlich ascites carcinoma cellsInhibitorinhibitorinhibit

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상품명:
Thymidine-5'-monophosphate disodium salt
Cat. No.:
HY-128738
수량:
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SAFETY DATA SHEET (SDS)

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