Thymidine-5'-monophosphate disodium salt
Based on 1 publication(s) in Google Scholar
Thymidine-5'-monophosphate (TMP) disodium salt is a key nucleotide in pyrimidine metabolism, and its kinase activity can be competitively inhibited by 5'-fluorothymidine. The level of Thymidine-5'-monophosphate disodium salt is closely associated with acute kidney injury.
For research use only. We do not sell to patients.
- Purity : 99.52%
- CAS No.: 33430-62-5
- Formula: C10H13N2Na2O8P
- Molecular Weight:366.17
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-W009162
Cytidine 5'-monophosphate -
HY-W009216
2'-Deoxycytidine-5'-monophosphate -
HY-101981
Uridine 5'-monophosphate -
HY-W013159
2'-Deoxyguanosine 5'-monophosphate disodium -
HY-W011142
2'-Deoxyuridine 5'-monophosphate disodium -
HY-W013175
Uridine 5'-monophosphate disodium salt -
HY-W010970
5'-Guanylic acid disodium salt -
HY-W016009
2'-Deoxyadenosine-5'-monophosphate -
HY-125818
Cytidine-5'-triphosphate -
HY-W008915
Cytidine 5'-diphosphate trisodium salt -
HY-A0181
Adenosine monophosphate -
HY-113066A
Guanosine 5'-diphosphate disodium salt
Publications Citing Use of MedChemExpress (MCE) Thymidine-5'-monophosphate disodium salt
MoreAll Endogenous Metabolite Isoforms
MoreAll DNA/RNA Synthesis Isoforms
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Biological Activity
Description
IC50 & Target
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Human Endogenous Metabolite |
Microbial Metabolite |
In Vitro
Thymidine-5'-monophosphate disodium salt is available for DNA synthesis as a deoxynucleotide monomer[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 33430-62-5
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Appearance Solid
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Molecular Weight 366.17
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Formula C10H13N2Na2O8P
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Color White to off-white
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SMILES
O[C@H]1C[C@H](N2C=C(C)C(NC2=O)=O)O[C@@H]1COP(O[Na])(O[Na])=O
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Synonyms
TMP disodium salt
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Pharm Biomed Anal
A novel UHPLC-MS/MS approach for simultaneous quantification of pyrimidine metabolites in human biofluids. [Abstract]2025 Nov 15:265:117026. PMID: 40544701
Solvent & Solubility
In Vitro:
H2O : 100 mg/mL (273.10 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (273.10 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (277 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Langen P, et al. 5'-Deoxy-5'-fluoro-thymidine, a biochemical analogue of thymidine-5'-monophosphate selectively inhibiting DNA synthesis. Eur J Biochem. 1968 Nov;6(3):344-51. [Content Brief]
[2]. Zhao L, et al. A novel UHPLC-MS/MS approach for simultaneous quantification of pyrimidine metabolites in human biofluids. J Pharm Biomed Anal. 2025;265:117026. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.7310 mL | 13.6549 mL | 27.3097 mL | 68.2743 mL |
| 5 mM | 0.5462 mL | 2.7310 mL | 5.4619 mL | 13.6549 mL | |
| 10 mM | 0.2731 mL | 1.3655 mL | 2.7310 mL | 6.8274 mL | |
| 15 mM | 0.1821 mL | 0.9103 mL | 1.8206 mL | 4.5516 mL | |
| 20 mM | 0.1365 mL | 0.6827 mL | 1.3655 mL | 3.4137 mL | |
| 25 mM | 0.1092 mL | 0.5462 mL | 1.0924 mL | 2.7310 mL | |
| 30 mM | 0.0910 mL | 0.4552 mL | 0.9103 mL | 2.2758 mL | |
| 40 mM | 0.0683 mL | 0.3414 mL | 0.6827 mL | 1.7069 mL | |
| 50 mM | 0.0546 mL | 0.2731 mL | 0.5462 mL | 1.3655 mL | |
| 60 mM | 0.0455 mL | 0.2276 mL | 0.4552 mL | 1.1379 mL | |
| 80 mM | 0.0341 mL | 0.1707 mL | 0.3414 mL | 0.8534 mL | |
| 100 mM | 0.0273 mL | 0.1365 mL | 0.2731 mL | 0.6827 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Thymidine-5'-monophosphate disodium salt Related Classifications
HY-128738 Related Classifications
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