2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 2'-Deoxyuridine 5'-monophosphate disodium

2'-Deoxyuridine 5'-monophosphate disodium  (Synonyms: dUMP disodium)

Cat. No.: HY-W011142 Pureté: 99.97%
COA
SDS
Instruction de manipulation Technical Support

2'-Deoxyuridine 5'-monophosphate (dUMP) disodium is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

2'-Deoxyuridine 5'-monophosphate disodium

2'-Deoxyuridine 5'-monophosphate disodium Chemical Structure

CAS No. : 42155-08-8

Size Prix Stock Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in Water En stock
Solid
250 mg En stock
500 mg   Obtenir un devis  
1 g   Obtenir un devis  

* Veuillez sélectionner la quantité avant d'ajouter des articles.

This product is a controlled substance and not for sale in your territory.

Avis client

Based on 1 Customer Validation

Other Forms of 2'-Deoxyuridine 5'-monophosphate disodium:

2'-Deoxyuridine 5'-monophosphate disodium Related Antibodies

Top Publications Citing Use of Products

Voir tous les produits spécifiques à Isoform Endogenous Metabolite:

Voir toutes les isoformes
Human Endogenous Metabolite Microbial Metabolite

  • Activité biologique

  • Pureté et documentation

  • Références

  • Avis client

Description

2'-Deoxyuridine 5'-monophosphate (dUMP) disodium is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis[1].

In Vitro

The compounds with anti-bacterial activity against the human pathogenic bacterium Helicobacter pylori markedly inhibit the NADPH oxidation and 2'-Deoxyuridine 5'-monophosphate (dUMP)-forming activities of HpThyX enzyme in vitro[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2'-Deoxyuridine 5'-monophosphate disodium Related Antibodies
Masse moléculaire

352.15

Formule

C9H11N2Na2O8P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1C[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(O[Na])(O[Na])=O
Structure Classification
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvant et solubilité
In Vitro: 

H2O : 233.33 mg/mL (662.59 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8397 mL 14.1985 mL 28.3970 mL
5 mM 0.5679 mL 2.8397 mL 5.6794 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (283.97 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureté et documentation

Purity: 99.97%

SDS (393 KB)

COA (252 KB) HNMR (259 KB) RP-HPLC (258 KB) LCMS (103 KB)

Instruction de manipulation (2659 KB)
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.8397 mL 14.1985 mL 28.3970 mL 70.9925 mL
5 mM 0.5679 mL 2.8397 mL 5.6794 mL 14.1985 mL
10 mM 0.2840 mL 1.4198 mL 2.8397 mL 7.0992 mL
15 mM 0.1893 mL 0.9466 mL 1.8931 mL 4.7328 mL
20 mM 0.1420 mL 0.7099 mL 1.4198 mL 3.5496 mL
25 mM 0.1136 mL 0.5679 mL 1.1359 mL 2.8397 mL
30 mM 0.0947 mL 0.4733 mL 0.9466 mL 2.3664 mL
40 mM 0.0710 mL 0.3550 mL 0.7099 mL 1.7748 mL
50 mM 0.0568 mL 0.2840 mL 0.5679 mL 1.4198 mL
60 mM 0.0473 mL 0.2366 mL 0.4733 mL 1.1832 mL
80 mM 0.0355 mL 0.1775 mL 0.3550 mL 0.8874 mL
100 mM 0.0284 mL 0.1420 mL 0.2840 mL 0.7099 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

2'-Deoxyuridine 5'-monophosphate disodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2'-Deoxyuridine 5'-monophosphate disodium42155-08-8dUMP disodiumEndogenous MetabolitedTMPDNA synthesisthymidylate synthaseInhibitorinhibitorinhibit

Vos produits récemment consultés:

Demande en ligne

Your information is safe with us. * Required Fields.

Nom du produit

  

Requested Quantity *

Nom du demandeur *

 

Civilité

Adresse e-mail *

 

Numéro de téléphone *

Department

 

Nom de l'organisation *

City

État

Country or Region *

      

Remarques

Bulk Inquiry

Inquiry Information

Nom du produit:
2'-Deoxyuridine 5'-monophosphate disodium
Cat. No.:
HY-W011142
Quantité:
MCE Japan Authorized Agent:

Avis client

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nom du produit

  

Lot #

Nom du demandeur *

 

Adresse e-mail *

Numéro de téléphone

 

Department *

Nom de l'organisation *

 

Country or Region *

Remarques

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.