2'-Deoxyuridine 5'-monophosphate disodium
Based on 1 Customer Validation
2'-Deoxyuridine 5'-monophosphate (dUMP) disodium is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis.
For research use only. We do not sell to patients.
- Purity : 99.97%
- CAS No.: 42155-08-8
- Formula: C9H11N2Na2O8P
- Molecular Weight:352.15
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-128738
Thymidine-5'-monophosphate disodium salt -
HY-101981
Uridine 5'-monophosphate -
HY-W016009
2'-Deoxyadenosine-5'-monophosphate -
HY-W010861
2'-Deoxycytidine-5'-diphosphate trisodium -
HY-W013159
2'-Deoxyguanosine 5'-monophosphate disodium -
HY-W010832
Uridine-5'-diphosphate disodium salt -
HY-W008915
Cytidine 5'-diphosphate trisodium salt -
HY-W008990
Xanthosine 5'-monophosphate sodium salt -
HY-W010968
5'-Adenylic acid sodium hydrate -
HY-W011142R
2'-Deoxyuridine 5'-monophosphate disodium (Standard) -
HY-W244398
2-Thiocytidine -
HY-137243
Adenosine 3',5'-diphosphate disodium
All Endogenous Metabolite Isoforms
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Biological Activity
Description
In Vitro
The compounds with anti-bacterial activity against the human pathogenic bacterium Helicobacter pylori markedly inhibit the NADPH oxidation and 2'-Deoxyuridine 5'-monophosphate (dUMP)-forming activities of HpThyX enzyme in vitro[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 42155-08-8
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Appearance Solid
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Molecular Weight 352.15
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Formula C9H11N2Na2O8P
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Color White to off-white
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SMILES
O[C@H]1C[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(O[Na])(O[Na])=O
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Synonyms
dUMP disodium
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
H2O : 233.33 mg/mL (662.59 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (283.97 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Zachary Newby, et al. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry. 2006 Jun 20;45(24):7415-28. [Content Brief]
[2]. Skouloubris S, et al. Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones. Open Biol. 2015 Jun;5(6):150015. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.8397 mL | 14.1985 mL | 28.3970 mL | 70.9925 mL |
| 5 mM | 0.5679 mL | 2.8397 mL | 5.6794 mL | 14.1985 mL | |
| 10 mM | 0.2840 mL | 1.4198 mL | 2.8397 mL | 7.0992 mL | |
| 15 mM | 0.1893 mL | 0.9466 mL | 1.8931 mL | 4.7328 mL | |
| 20 mM | 0.1420 mL | 0.7099 mL | 1.4198 mL | 3.5496 mL | |
| 25 mM | 0.1136 mL | 0.5679 mL | 1.1359 mL | 2.8397 mL | |
| 30 mM | 0.0947 mL | 0.4733 mL | 0.9466 mL | 2.3664 mL | |
| 40 mM | 0.0710 mL | 0.3550 mL | 0.7099 mL | 1.7748 mL | |
| 50 mM | 0.0568 mL | 0.2840 mL | 0.5679 mL | 1.4198 mL | |
| 60 mM | 0.0473 mL | 0.2366 mL | 0.4733 mL | 1.1832 mL | |
| 80 mM | 0.0355 mL | 0.1775 mL | 0.3550 mL | 0.8874 mL | |
| 100 mM | 0.0284 mL | 0.1420 mL | 0.2840 mL | 0.7099 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
2'-Deoxyuridine 5'-monophosphate disodium Related Classifications
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