2'-Deoxyuridine 5'-monophosphate disodium

Name: 2'-Deoxyuridine 5'-monophosphate disodium
Brand: MedChemExpress
SKU: HY-W011142
Rating: 4.5 (1 reviews)

Cat. No.: HY-W011142 Purity: 98.53%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

2'-Deoxyuridine 5'-monophosphate disodium is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis.

For research use only. We do not sell to patients.

2'-Deoxyuridine 5'-monophosphate disodium Chemical Structure

CAS No. : 42155-08-8

Size	Price	Stock	Quantity
250 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

352.15

Formula

C₉H₁₁N₂Na₂O₈P

CAS No.

42155-08-8

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1C[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(O[Na])(O[Na])=O

Structure Classification

Others

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 250 mg/mL (709.92 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8397 mL	14.1985 mL	28.3970 mL
5 mM	0.5679 mL	2.8397 mL	5.6794 mL
10 mM	0.2840 mL	1.4198 mL	2.8397 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (283.97 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.53%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (252 KB) HNMR (273 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Zachary Newby, et al. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry. 2006 Jun 20;45(24):7415-28. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.8397 mL	14.1985 mL	28.3970 mL	70.9925 mL
	5 mM	0.5679 mL	2.8397 mL	5.6794 mL	14.1985 mL
	10 mM	0.2840 mL	1.4198 mL	2.8397 mL	7.0992 mL
	15 mM	0.1893 mL	0.9466 mL	1.8931 mL	4.7328 mL
	20 mM	0.1420 mL	0.7099 mL	1.4198 mL	3.5496 mL
	25 mM	0.1136 mL	0.5679 mL	1.1359 mL	2.8397 mL
	30 mM	0.0947 mL	0.4733 mL	0.9466 mL	2.3664 mL
	40 mM	0.0710 mL	0.3550 mL	0.7099 mL	1.7748 mL
	50 mM	0.0568 mL	0.2840 mL	0.5679 mL	1.4198 mL
	60 mM	0.0473 mL	0.2366 mL	0.4733 mL	1.1832 mL
	80 mM	0.0355 mL	0.1775 mL	0.3550 mL	0.8874 mL
	100 mM	0.0284 mL	0.1420 mL	0.2840 mL	0.7099 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.