2'-Deoxyuridine 5'-monophosphate
2'-Deoxyuridine 5'-monophosphate (dUMP) is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis.
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- CAS No.: 964-26-1
- Formula: C9H13N2O8P
- Molecular Weight:308.18
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
The compounds with anti-bacterial activity against the human pathogenic bacterium Helicobacter pylori markedly inhibit the NADPH oxidation and 2'-Deoxyuridine 5'-monophosphate (dUMP)-forming activities of HpThyX enzyme in vitro[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 964-26-1
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Molecular Weight 308.18
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Formula C9H13N2O8P
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SMILES
O[C@H]1C[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(O)(O)=O
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Synonyms
dUMP
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Zachary Newby, et al. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry. 2006 Jun 20;45(24):7415-28. [Content Brief]
[2]. Skouloubris S, et al. Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones. Open Biol. 2015 Jun;5(6):150015. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2'-Deoxyuridine 5'-monophosphate Related Classifications
HY-W394006 Related Classifications
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