Uridine 5'-monophosphate disodium salt
Based on 4 publication(s) in Google Scholar
Uridine 5'-monophosphate (5'-Uridylic acid) disodium salt is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate disodium salt can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.
For research use only. We do not sell to patients.
- Purity : 99.90%
- CAS No.: 3387-36-8
- Formula: C9H11N2Na2O9P
- Molecular Weight:368.14
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-W009162
Cytidine 5'-monophosphate -
HY-W010970
5'-Guanylic acid disodium salt -
HY-A0181
Adenosine monophosphate -
HY-128738
Thymidine-5'-monophosphate disodium salt -
HY-D0199
Adenosine 5'-diphosphate disodium -
HY-W011012
Adenosine 5'-monophosphate disodium -
HY-N0091
Hypoxanthine -
HY-B1449
Uridine -
HY-I0960
Uracil -
HY-W009162R
Cytidine 5'-monophosphate (Standard) -
HY-B0228
Adenosine -
HY-B2176
ATP
Publications Citing Use of MedChemExpress (MCE) Uridine 5'-monophosphate disodium salt
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Description
In Vitro
Uridine 5'-monophosphate (10 mM; 6 h) disodium salt promotes late apoptosis in pig intestinal epithelial cells IPEC-J2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:IPEC-J2
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Concentration:10 mM
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Incubation Time:6 h
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Result:Increased the late apoptosis rate.
In Vivo
Uridine 5'-monophosphate (0.02-1 mmol/kg; i.g.; single dose) disodium salt can enhance the synthesis of CDP-choline in the brains of gerbils[2].
Uridine 5'-monophosphate (30 mg/kg; i.v.; single dose) disodium salt has protective properties for the heart in rats, preventing ischemic injury and some arrhythmias[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Piglets[1]
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Dosage:476 mg; daily; 10 days
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Administration:Oral
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Result:Improved daily weight gain in piglets, reduced diarrhea rates, lowered the expression of jejunal mucosal CAD and RRM2, and increased the apoptosis rate of intestinal epithelial cells.
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Animal Model:Male gerbils (60-80g)[2]
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Dosage:0.02, 0.05, 0.1, 1 mmol/kg, single dose
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Administration:i.g.
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Result:Increased choline levels after 15 minutes, and after thirty minutes, plasma uridine and brain tissue uridine increased, with plasma and brain cytidine also rising significantly.
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Animal Model:Male wistar rats (250-300 g)[3]
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Dosage:30 mg/kg, single dose
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Administration:i.v.
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Result:Reduced the index of myocardial ischemia changes and T-wave amplitude, decreased the frequency of ventricular premature beats, and shortened the duration of ventricular tachycardia and fibrillation.
Chemical Information
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CAS No. 3387-36-8
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Appearance Solid
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Molecular Weight 368.14
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Formula C9H11N2Na2O9P
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Color White to off-white
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SMILES
O[C@@H]([C@H](N(C1=O)C=CC(N1)=O)O2)[C@H](O)[C@H]2COP(O[Na])(O[Na])=O
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Synonyms
5'-Uridylic acid disodium salt
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
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Journal Impact Factor
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Most Recent
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Int J Biol Macromol
Reticuline isomerase AKR1B1 with aldo-keto reductase activity and detoxification function from the insect Blaps rhynchopetera. [Abstract]2026 Mar:352:151224. PMID: 41791543 -
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Pestic Biochem Physiol
Plumbagin targets dihydroorotase in Magnaporthe oryzae to inhibit infection and shows antifungal activity against multiple phytopathogenic fungi. [Abstract]2026 Jun:221:107096. PMID: 42264707 -
J Pharm Biomed Anal
A novel UHPLC-MS/MS approach for simultaneous quantification of pyrimidine metabolites in human biofluids. [Abstract]2025 Nov 15:265:117026. PMID: 40544701
Solvent & Solubility
In Vitro:
H2O : ≥ 50 mg/mL (135.82 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (271.64 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (281 KB)
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SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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Handling Instructions (2659 KB)
References
[1]. Li G, et al. Uridine/UMP metabolism and their function on the gut in segregated early weaned piglets. Food Funct. 2019 Jul 17;10(7):4081-4089. [Content Brief]
[2]. Mehmet Cansev, et al. Oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils. Brain Res. 2005 Oct 5;1058(1-2):101-8. [Content Brief]
[3]. Irina B Krylova, et al. The cardioprotective effect of uridine and uridine-5'-monophosphate: the role of the mitochondrial ATP-dependent potassium channel. Exp Gerontol. 2006 Jul;41(7):697-703. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.7164 mL | 13.5818 mL | 27.1636 mL | 67.9089 mL |
| 5 mM | 0.5433 mL | 2.7164 mL | 5.4327 mL | 13.5818 mL | |
| 10 mM | 0.2716 mL | 1.3582 mL | 2.7164 mL | 6.7909 mL | |
| 15 mM | 0.1811 mL | 0.9055 mL | 1.8109 mL | 4.5273 mL | |
| 20 mM | 0.1358 mL | 0.6791 mL | 1.3582 mL | 3.3954 mL | |
| 25 mM | 0.1087 mL | 0.5433 mL | 1.0865 mL | 2.7164 mL | |
| 30 mM | 0.0905 mL | 0.4527 mL | 0.9055 mL | 2.2636 mL | |
| 40 mM | 0.0679 mL | 0.3395 mL | 0.6791 mL | 1.6977 mL | |
| 50 mM | 0.0543 mL | 0.2716 mL | 0.5433 mL | 1.3582 mL | |
| 60 mM | 0.0453 mL | 0.2264 mL | 0.4527 mL | 1.1318 mL | |
| 80 mM | 0.0340 mL | 0.1698 mL | 0.3395 mL | 0.8489 mL | |
| 100 mM | 0.0272 mL | 0.1358 mL | 0.2716 mL | 0.6791 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Uridine 5'-monophosphate disodium salt Related Classifications
HY-W013175 Related Classifications
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