Adenosine 5'-monophosphate disodium

Name: Adenosine 5'-monophosphate disodium
Brand: MedChemExpress
SKU: HY-W011012
Rating: 5.0 (6 reviews)

Cat. No.: HY-W011012 Purity: 99.63%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes.

For research use only. We do not sell to patients.

Adenosine 5'-monophosphate disodium Chemical Structure

CAS No. : 4578-31-8

Size	Price	Stock	Quantity
100 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
1 g		Get quote
5 g		Get quote

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Based on 6 publication(s) in Google Scholar

Other Forms of Adenosine 5'-monophosphate disodium:

Adenosine monophosphate In-stock
Adenosine 5'-monophosphate monohydrate In-stock
Adenosine monophosphate-¹⁵N₅ dilithium In-stock
Adenosine 5'-monophosphate-¹³C disodium Get quote
Adenosine 5'-monophosphate-d₂ disodium Get quote
Adenosine-5'-monophosphate-¹⁵N₅ disodium Get quote

6 Publications Citing Use of MCE Adenosine 5'-monophosphate disodium

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Adenosine Receptor Isoform Specific Products:

View All Isoforms

Adenosine A₁ receptor (A₁R) Adenosine A_2A receptor (A_2AR) Adenosine A_2B receptor (A_2BR) Adenosine A₃ receptor (A₃R)

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[3]

A2BR

In Vivo

Adenosine 5'-monophosphate (10 and 13 mg/L in distilled water, for 25 weeks) disodium improves glucose metabolism in mice with HFD-induced diabetes^[1].
Adenosine 5'-monophosphate (40-800 mg/kg, i.p.) lowers body temperature via the adenosine receptor in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 J mice with high-fat diet-induced diabetes^[1]
Dosage:	10 and 13 mg/L
Administration:	Added in distilled water, for 25 weeks
Result:	Enhanced phosphorylation of AMPK and mRNA levels of genes involved in lipid oxidation in the skeletal muscle.

Molecular Weight

391.18

Formula

C₁₀H₁₂N₅Na₂O₇P

CAS No.

4578-31-8

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1COP(O[Na])(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (255.64 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5564 mL	12.7818 mL	25.5637 mL
5 mM	0.5113 mL	2.5564 mL	5.1127 mL
10 mM	0.2556 mL	1.2782 mL	2.5564 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.63%

Select Batch:

Data Sheet (278 KB) SDS (393 KB)

COA (253 KB) HNMR (118 KB) RP-HPLC (221 KB)

Handling Instructions (2659 KB)

References

[1]. Ardiansyah, et al. Adenosine and adenosine-5'-monophosphate ingestion ameliorates abnormal glucose metabolism in mice fed a high-fat diet. BMC Complement Altern Med. 2018 Nov 14;18(1):304. [Content Brief]

[2]. Steven J. Swoap, et al. AMP does not induce torpor. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2007 293:1, R468-R473.

[3]. Holien JK, et al. AMP and adenosine are both ligands for adenosine 2B receptor signaling. Bioorg Med Chem Lett. 2018 Jan 15;28(2):202-206. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.5564 mL	12.7818 mL	25.5637 mL	63.9092 mL
	5 mM	0.5113 mL	2.5564 mL	5.1127 mL	12.7818 mL
	10 mM	0.2556 mL	1.2782 mL	2.5564 mL	6.3909 mL
	15 mM	0.1704 mL	0.8521 mL	1.7042 mL	4.2606 mL
	20 mM	0.1278 mL	0.6391 mL	1.2782 mL	3.1955 mL
	25 mM	0.1023 mL	0.5113 mL	1.0225 mL	2.5564 mL
	30 mM	0.0852 mL	0.4261 mL	0.8521 mL	2.1303 mL
	40 mM	0.0639 mL	0.3195 mL	0.6391 mL	1.5977 mL
	50 mM	0.0511 mL	0.2556 mL	0.5113 mL	1.2782 mL
	60 mM	0.0426 mL	0.2130 mL	0.4261 mL	1.0652 mL
	80 mM	0.0320 mL	0.1598 mL	0.3195 mL	0.7989 mL
	100 mM	0.0256 mL	0.1278 mL	0.2556 mL	0.6391 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.