Adenosine 5'-monophosphate disodium

Name: Adenosine 5'-monophosphate disodium
Brand: MedChemExpress
SKU: HY-W011012
Rating: 5.0 (18 reviews)

Cat. No.: HY-W011012 Purity: 99.92%: Data Sheet
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Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes.

For research use only. We do not sell to patients.

CAS No. : 4578-31-8

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	Get quote

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Customer Review

Based on 18 publication(s) in Google Scholar

Other Forms of Adenosine 5'-monophosphate disodium:

Adenosine monophosphate-¹⁵N₅ dilithium In-stock
Adenosine 5'-monophosphate-¹³C disodium In-stock
Adenosine monophosphate In-stock
Adenosine 5'-monophosphate monohydrate In-stock
Adenosine 5'-monophosphate-d₂ disodium Get quote
Adenosine-5'-monophosphate-¹⁵N₅ disodium Get quote
Adenosine 5'-monophosphate disodium (Standard) Get quote

18 Publications Citing Use of MCE Adenosine 5'-monophosphate disodium

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ELISA

Cell Proliferation/Viability Assay

Cell Imaging/Staining

: Adenosine 5'-monophosphate disodium purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2025 Jun 2;16(1):277. [Abstract]; Flow cytometry analysis of adenosine A2aR and A2bR expression treated with Adenosine monophosphate (AMP) (100 μM).

: Adenosine 5'-monophosphate disodium purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2024 May 14:708:149814.; The levels of ROS was significantly improved in the AMPD2 overexpression group after treatment with Adenosine monophosphate (AMP) (10 μM, 24 h).

: Adenosine 5'-monophosphate disodium purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2024 May 14:708:149814.; Lower expression of total p38, phosphorylated p38 and Gpx4 could be observed after Adenosine monophosphate (AMP) (10 μM, 24 h) treatment in the AMPD2 overexpression group detected by western blot analysis.

: Adenosine 5'-monophosphate disodium purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2023 Sep 29;14(1):277. [Abstract]; IFN-γ production was detected by ELISA in the cell culture supernatant, ERCs or NC-ERCs significantly inhibited the differentiation of activated CD4⁺ T cells to Th1 cells compared with CD73-KO-ERCs, as well as the production of IFN-γ, especially in the presence of Adenosine monophosphate (AMP) (50 μM, 72 h).

: Adenosine 5'-monophosphate disodium purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2023 Sep 29;14(1):277. [Abstract]; Adenosine monophosphate (AMP) (50 μM, 72 h) was introduced to the culture medium to ensure sufficient substrate for CD73 in all situations, the reduction of CD69 expression on CD4⁺ T cells was more apparent when cultured with NC-ERCs than CD73-KO-ERCs.

: Adenosine 5'-monophosphate disodium purchased from MedChemExpress. Usage Cited in: Genes (Basel). 2022 Dec 16;13(12):2384. [Abstract]; The Survival rate of M. coruscus larvae after being treated with Adenosine monophosphate (AMP) (0.5, 1. 2.5 mM, 72 h) The figures in the legend represent the concentration (mM).

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[3]

A2BR

In Vivo

Adenosine 5'-monophosphate (10 and 13 mg/L in distilled water, for 25 weeks) disodium improves glucose metabolism in mice with HFD-induced diabetes^[1].
Adenosine 5'-monophosphate (40-800 mg/kg, i.p.) lowers body temperature via the adenosine receptor in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 J mice with high-fat diet-induced diabetes^[1]
Dosage:	10 and 13 mg/L
Administration:	Added in distilled water, for 25 weeks
Result:	Enhanced phosphorylation of AMPK and mRNA levels of genes involved in lipid oxidation in the skeletal muscle.

Molecular Weight

391.18

Formula

C₁₀H₁₂N₅Na₂O₇P

CAS No.

4578-31-8

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1COP(O[Na])(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (255.64 mM; Need ultrasonic)

DMSO : 2 mg/mL (5.11 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5564 mL	12.7818 mL	25.5637 mL
5 mM	0.5113 mL	2.5564 mL	5.1127 mL
10 mM	0.2556 mL	1.2782 mL	2.5564 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (278 KB) SDS (394 KB)

COA (254 KB) HNMR (112 KB) RP-HPLC (101 KB) LCMS (233 KB)

Handling Instructions (2659 KB)

References

[1]. Ardiansyah, et al. Adenosine and adenosine-5'-monophosphate ingestion ameliorates abnormal glucose metabolism in mice fed a high-fat diet. BMC Complement Altern Med. 2018 Nov 14;18(1):304. [Content Brief]

[2]. Steven J. Swoap, et al. AMP does not induce torpor. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2007 293:1, R468-R473.

[3]. Holien JK, et al. AMP and adenosine are both ligands for adenosine 2B receptor signaling. Bioorg Med Chem Lett. 2018 Jan 15;28(2):202-206. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.5564 mL	12.7818 mL	25.5637 mL	63.9092 mL
DMSO / H₂O	5 mM	0.5113 mL	2.5564 mL	5.1127 mL	12.7818 mL
H₂O	10 mM	0.2556 mL	1.2782 mL	2.5564 mL	6.3909 mL
	15 mM	0.1704 mL	0.8521 mL	1.7042 mL	4.2606 mL
	20 mM	0.1278 mL	0.6391 mL	1.2782 mL	3.1955 mL
	25 mM	0.1023 mL	0.5113 mL	1.0225 mL	2.5564 mL
	30 mM	0.0852 mL	0.4261 mL	0.8521 mL	2.1303 mL
	40 mM	0.0639 mL	0.3195 mL	0.6391 mL	1.5977 mL
	50 mM	0.0511 mL	0.2556 mL	0.5113 mL	1.2782 mL
	60 mM	0.0426 mL	0.2130 mL	0.4261 mL	1.0652 mL
	80 mM	0.0320 mL	0.1598 mL	0.3195 mL	0.7989 mL
	100 mM	0.0256 mL	0.1278 mL	0.2556 mL	0.6391 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.