Adenosine 5'-monophosphate disodium
Based on 22 publication(s) in Google Scholar
Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes.
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 4578-31-8
- Formula: C10H12N5Na2O7P
- Molecular Weight:391.18
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications Citing Use of MedChemExpress (MCE) Adenosine 5'-monophosphate disodium
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Cell. 2025 Oct 30;188(22):6151-6169.e24. [Abstract]
- Exploration. 2026 Jun 22. [Abstract]
- Theranostics. 2024 Aug 12;14(12):4874-4893. [Abstract]
- Theranostics. 2020 Aug 13;10(22):10245-10261. [Abstract]
- MedComm (2020). 2025 Jan 8;6(1):e70046. [Abstract]
- J Exp Med. 2026 Jan 5;223(1):e20250440. [Abstract]
- Cell Chem Biol. 2026 Jun 18;33(6):767-784.e7. [Abstract]
- Stem Cell Res Ther. 2025 Jun 2;16(1):277. [Abstract]
- Stem Cell Res Ther. 2025 Mar 26;16(1):148. [Abstract]
- Stem Cell Res Ther. 2023 Sep 29;14(1):277. [Abstract]
- Anal Chem. 2025 May 13;97(18):9827-9835. [Abstract]
- Biochem Pharmacol. 2026 Sep;251(Pt 1):118080. [Abstract]
- Molecules. 2025 Mar 9;30(6):1224. [Abstract]
- Molecules. 2023 Apr 11;28(8):3375. [Abstract]
- Mar Pollut Bull. 2025 Nov:220:118455. [Abstract]
- Genes (Basel). 2022 Dec 16;13(12):2384. [Abstract]
- Vet Microbiol. 2026 May:316:110992. [Abstract]
- Biochem Biophys Res Commun. 2024 May 14:708:149814. [Abstract]
- Res Sq. 2026 Apr 22:rs.3.rs-9192680. [Abstract]
- University of Cambridge. 2023 Feb.
- Research Square Preprint. 2022 May.
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Flow Cytometry
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Cell Imaging/Staining
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WB
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ELISA
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Flow Cytometry
All Adenosine Receptor Isoforms
More
Biological Activity
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A2BR |
Adenosine 5'-monophosphate (40-800 mg/kg, i.p.) lowers body temperature via the adenosine receptor in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 J mice with high-fat diet-induced diabetes[1]
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Dosage:10 and 13 mg/L
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Administration:Added in distilled water, for 25 weeks
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Result:Enhanced phosphorylation of AMPK and mRNA levels of genes involved in lipid oxidation in the skeletal muscle.
Chemical Information
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CAS No. 4578-31-8
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Appearance Solid
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Molecular Weight 391.18
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Formula C10H12N5Na2O7P
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Color White to off-white
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1COP(O[Na])(O[Na])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (22)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cell
Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism. [Abstract]2025 Oct 30;188(22):6151-6169.e24. PMID: 40840445 -
Exploration
Radiolabeled Coordination Polymer-Loaded Microneedles for Synergistic Melanoma Brachytherapy-Immunotherapy via STING Activation and Pyroptosis. [Abstract]2026 Jun 22. PMID: 42382697 -
Theranostics
Engaging natural regulatory myeloid cells to restrict T-cell hyperactivation-induced liver inflammation via extracellular vesicle-mediated purine metabolism regulation. [Abstract]2024 Aug 12;14(12):4874-4893. PMID: 39239508 -
Theranostics
Histone deacetylase inhibitors promote epithelial-mesenchymal transition in Hepatocellular Carcinoma via AMPK-FOXO1-ULK1 signaling axis-mediated autophagy. [Abstract]2020 Aug 13;10(22):10245-10261. PMID: 32929346 -
MedComm (2020)
Novel antibiotics against Staphylococcus aureus without detectable resistance by targeting proton motive force and FtsH. [Abstract]2025 Jan 8;6(1):e70046. PMID: 39781293 -
J Exp Med
2026 Jan 5;223(1):e20250440. PMID: 41165618 -
Cell Chem Biol
The cytotoxic effect of prexasertib is a consequence of dual inhibition on both CHK1 and AMPK. [Abstract]2026 Jun 18;33(6):767-784.e7. PMID: 42061410 -
Stem Cell Res Ther
CD73-expressing endometrial regenerative cell-derived exosomes mitigate acute cardiac allograft rejection through regulating adenosine metabolism in mice. [Abstract]2025 Jun 2;16(1):277. PMID: 40457389
Adenosine 5'-monophosphate disodium purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2025 Jun 2;16(1):277. [Abstract]
Flow cytometry analysis of adenosine A2aR and A2bR expression treated with Adenosine monophosphate (AMP) (100 μM).
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Stem Cell Res Ther
Exosomes derived from a mesenchymal-like endometrial regenerative cells ameliorate renal ischemia reperfusion injury through delivery of CD73. [Abstract]2025 Mar 26;16(1):148. PMID: 40140882 -
Stem Cell Res Ther
CD73 mediates the therapeutic effects of endometrial regenerative cells in concanavalin A-induced hepatitis by regulating CD4+ T cells. [Abstract]2023 Sep 29;14(1):277. PMID: 37775797
Adenosine 5'-monophosphate disodium purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2023 Sep 29;14(1):277. [Abstract]
IFN-γ production was detected by ELISA in the cell culture supernatant, ERCs or NC-ERCs significantly inhibited the differentiation of activated CD4+ T cells to Th1 cells compared with CD73-KO-ERCs, as well as the production of IFN-γ, especially in the presence of Adenosine monophosphate (AMP) (50 μM, 72 h).
Adenosine 5'-monophosphate disodium purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2023 Sep 29;14(1):277. [Abstract]
Adenosine monophosphate (AMP) (50 μM, 72 h) was introduced to the culture medium to ensure sufficient substrate for CD73 in all situations, the reduction of CD69 expression on CD4+ T cells was more apparent when cultured with NC-ERCs than CD73-KO-ERCs.
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Anal Chem
Ultrahigh Flow Regulated Discharge Coupling with Targeted Mass Spectrometry Analysis: Real Time Capturing Biomolecules in Exhaled Breath. [Abstract]2025 May 13;97(18):9827-9835. PMID: 40302637 -
Biochem Pharmacol
Exosomal CD73 from endometrial regenerative cells confers protective effects against ischemia-reperfusion injury in kidney transplantation. [Abstract]2026 Sep;251(Pt 1):118080. PMID: 42162765 -
Molecules
Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors. [Abstract]2025 Mar 9;30(6):1224. PMID: 40142001 -
Molecules
Untargeted Metabolomics Using UHPLC-HRMS Reveals Metabolic Changes of Fresh-Cut Potato during Browning Process. [Abstract]2023 Apr 11;28(8):3375. PMID: 37110608 -
Mar Pollut Bull
Microplastics exposure affects the feeding behavior of the whiteleg shrimp Litopenaeus vannamei by impairing the appetite, olfaction and digestion. [Abstract]2025 Nov:220:118455. PMID: 40680651 -
Genes (Basel)
2022 Dec 16;13(12):2384. PMID: 36553651
Adenosine 5'-monophosphate disodium purchased from MedChemExpress. Usage Cited in: Genes (Basel). 2022 Dec 16;13(12):2384. [Abstract]
The Survival rate of M. coruscus larvae after being treated with Adenosine monophosphate (AMP) (0.5, 1. 2.5 mM, 72 h) The figures in the legend represent the concentration (mM).
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Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607 -
Biochem Biophys Res Commun
Feedback activation of CD73-Adenosine axis attenuates the antitumor immunity of STING pathway. [Abstract]2024 May 14:708:149814. PMID: 38531218
Adenosine 5'-monophosphate disodium purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2024 May 14:708:149814. [Abstract]
The levels of ROS was significantly improved in the AMPD2 overexpression group after treatment with Adenosine monophosphate (AMP) (10 μM, 24 h).
Adenosine 5'-monophosphate disodium purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2024 May 14:708:149814. [Abstract]
Lower expression of total p38, phosphorylated p38 and Gpx4 could be observed after Adenosine monophosphate (AMP) (10 μM, 24 h) treatment in the AMPD2 overexpression group detected by western blot analysis.
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Res Sq
A phosphorylation switch at MRE11 links ATM-ATR and calcium signaling to safeguard stalled replication fork stability. [Abstract]2026 Apr 22:rs.3.rs-9192680. PMID: 42078910 -
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Solvent & Solubility
H2O : 100 mg/mL (255.64 mM; Need ultrasonic)
DMSO : 2 mg/mL (5.11 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Ardiansyah, et al. Adenosine and adenosine-5'-monophosphate ingestion ameliorates abnormal glucose metabolism in mice fed a high-fat diet. BMC Complement Altern Med. 2018 Nov 14;18(1):304. [Content Brief]
[3]. Holien JK, et al. AMP and adenosine are both ligands for adenosine 2B receptor signaling. Bioorg Med Chem Lett. 2018 Jan 15;28(2):202-206. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.5564 mL | 12.7818 mL | 25.5637 mL | 63.9092 mL |
| 5 mM | 0.5113 mL | 2.5564 mL | 5.1127 mL | 12.7818 mL | |
| H2O | 10 mM | 0.2556 mL | 1.2782 mL | 2.5564 mL | 6.3909 mL |
| 15 mM | 0.1704 mL | 0.8521 mL | 1.7042 mL | 4.2606 mL | |
| 20 mM | 0.1278 mL | 0.6391 mL | 1.2782 mL | 3.1955 mL | |
| 25 mM | 0.1023 mL | 0.5113 mL | 1.0225 mL | 2.5564 mL | |
| 30 mM | 0.0852 mL | 0.4261 mL | 0.8521 mL | 2.1303 mL | |
| 40 mM | 0.0639 mL | 0.3195 mL | 0.6391 mL | 1.5977 mL | |
| 50 mM | 0.0511 mL | 0.2556 mL | 0.5113 mL | 1.2782 mL | |
| 60 mM | 0.0426 mL | 0.2130 mL | 0.4261 mL | 1.0652 mL | |
| 80 mM | 0.0320 mL | 0.1598 mL | 0.3195 mL | 0.7989 mL | |
| 100 mM | 0.0256 mL | 0.1278 mL | 0.2556 mL | 0.6391 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.