33430-62-5
33430-62-5
Chemical Structure
Thymidine-5'-monophosphate disodium salt
Synonym(s): TMP disodium salt
- CAS No.: 33430-62-5
- Formula:C10H13N2Na2O8P
- Molecular Weight:366.17
IUPAC Name: sodium ((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl phosphate
InChIKey: AGSQMPPRYZYDFV-ZJWYQBPBSA-L
SMILES: O[C@H]1C[C@H](N2C=C(C)C(NC2=O)=O)O[C@@H]1COP(O[Na])(O[Na])=O
Biological Activity: Thymidine-5'-monophosphate (TMP) disodium salt is a key nucleotide in pyrimidine metabolism, and its kinase activity can be competitively inhibited by 5'-fluorothymidine. The level of Thymidine-5'-monophosphate disodium salt is closely associated with acute kidney injury[1][2].
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Thymidine-5'-monophosphate disodium salt | 99.52% | Thymidine-5'-monophosphate (TMP) disodium salt is a key nucleotide in pyrimidine metabolism, and its kinase activity can be competitively inhibited by 5'-fluorothymidine. The level of Thymidine-5'-monophosphate disodium salt is closely associated with acute kidney injury. | ||||||||||||||||||||
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Thymidine-5'-monophosphate disodium salt (Standard) | ≥98% | Thymidine-5'-monophosphate (TMP) disodium salt (Standard) is the analytical standard of Thymidine-5'-monophosphate disodium salt (HY-128738). This product is intended for research and analytical applications. Thymidine-5'-monophosphate (TMP) disodium salt is a key nucleotide in pyrimidine metabolism, and its kinase activity can be competitively inhibited by 5'-fluorothymidine. The level of Thymidine-5'-monophosphate disodium salt is closely associated with acute kidney injury. | ||||||||||||||||||||
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References
- [1]. Langen P, et al. 5'-Deoxy-5'-fluoro-thymidine, a biochemical analogue of thymidine-5'-monophosphate selectively inhibiting DNA synthesis. Eur J Biochem. 1968 Nov;6(3):344-51. [Content Brief]
- [2]. Zhao L, et al. A novel UHPLC-MS/MS approach for simultaneous quantification of pyrimidine metabolites in human biofluids. J Pharm Biomed Anal. 2025;265:117026. [Content Brief]
