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Cat. No.: HY-131576B

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Thymidine 5′-diphosphate disodium

(Synonyms: dTDP disodium)

Thymidine 5′-diphosphate (dTDP) disodium is a key product for pyrimidine synthesis in organisms. Thymidine 5′-diphosphate is generated via the phosphorylation of thymidine 5'-monophosphate (dTMP) catalyzed by thymidylate kinase (TMPK), a process requiring ATP and Mg²⁺. Thymidine 5′-diphosphate disodium is further catalyzed by TMPK into thymidine 5'-triphosphate (dTTP). Detection of Thymidine 5′-diphosphate levels enables the assessment of TMPK activity.

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CAS No.: 28120-41-4
Formula: C₁₀H₁₄N₂Na₂O₁₁P₂
Molecular Weight:446.15

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Thymidine 5′-diphosphate disodium Chemical Structure

CAS No.: 28120-41-4

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Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vitro

Thymidine 5′-diphosphate is produced by thymidylate kinase (TMPK)-catalyzed phosphorylation of thymidine 5'-monophosphate (dTMP), a process requiring ATP and Mg²⁺, and is further catalyzed by TMPK into thymidine 5'-triphosphate (dTTP). Detection of Thymidine 5′-diphosphate levels allows the measurement of TMPK activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 28120-41-4
Molecular Weight 446.15
Formula C₁₀H₁₄N₂Na₂O₁₁P₂
SMILES

O[C@H]1C[C@H](N(C=C(C(N2)=O)C)C2=O)O[C@@H]1COP(OP(O[Na])(O[Na])=O)(O)=O
Synonyms

dTDP disodium
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tzeng HF, et al. Simultaneous determination of thymidylate and thymidine diphosphate by capillary electrophoresis as a rapid monitoring tool for thymidine kinase and thymidylate kinase activities. Electrophoresis. 2005 Jun;26(11):2225-30. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Thymidine 5′-diphosphate disodium

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Thymidine 5′-diphosphate disodium

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Thymidine 5′-diphosphate disodium Related Classifications

HY-131576B Related Classifications