Thymidine 5′-diphosphate disodium  (Synonyms: dTDP disodium)

Thymidine 5′-diphosphate (dTDP) disodium is a key product for pyrimidine synthesis in organisms. Thymidine 5′-diphosphate is generated via the phosphorylation of thymidine 5'-monophosphate (dTMP) catalyzed by thymidylate kinase (TMPK), a process requiring ATP and Mg²⁺. Thymidine 5′-diphosphate disodium is further catalyzed by TMPK into thymidine 5'-triphosphate (dTTP). Detection of Thymidine 5′-diphosphate levels enables the assessment of TMPK activity^[1].

Thymidine 5′-diphosphate is produced by thymidylate kinase (TMPK)-catalyzed phosphorylation of thymidine 5'-monophosphate (dTMP), a process requiring ATP and Mg²⁺, and is further catalyzed by TMPK into thymidine 5'-triphosphate (dTTP). Detection of Thymidine 5′-diphosphate levels allows the measurement of TMPK activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

446.15

C₁₀H₁₄N₂Na₂O₁₁P₂

28120-41-4

O[C@H]1C[C@H](N(C=C(C(N2)=O)C)C2=O)O[C@@H]1COP(OP(O[Na])(O[Na])=O)(O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tzeng HF, et al. Simultaneous determination of thymidylate and thymidine diphosphate by capillary electrophoresis as a rapid monitoring tool for thymidine kinase and thymidylate kinase activities. Electrophoresis. 2005 Jun;26(11):2225-30.  [Content Brief]