2. Apoptosis Epigenetics
  3. Apoptosis MicroRNA
  4. Thymidine 3',5'-diphosphate tetrasodium

Thymidine 3',5'-diphosphate tetrasodium  (Synonyms: Deoxythymidine 3′,5′-diphosphate tetrasodium; pdTp tetrasodium)

Cat. No.: HY-115581A Purity: ≥97.0%
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Thymidine 3',5'-diphosphate (Deoxythymidine 3′,5′-diphosphate) tetrasodium is a selective inhibitor of staphylococcal nuclease and tudor domain containing 1 (SND1, the MicroRNA regulatory complex RISC subunit) and [3,5-2H2] tyrosyl nuclease. Thymidine 3',5'-diphosphate tetrasodium has anti-tumor activity and can also be used as a catalyst in biochemical reactions.

For research use only. We do not sell to patients.

Thymidine 3',5'-diphosphate tetrasodium Chemical Structure

Thymidine 3',5'-diphosphate tetrasodium Chemical Structure

CAS No. : 118675-87-9

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1024 In-stock
Solution
10 mM * 1 mL in DMSO USD 1024 In-stock
Solid
1 mg USD 350 In-stock
5 mg USD 950 In-stock
10 mg USD 1500 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Thymidine 3',5'-diphosphate tetrasodium:

Thymidine 3',5'-diphosphate tetrasodium Related Antibodies

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Description

Thymidine 3',5'-diphosphate (Deoxythymidine 3′,5′-diphosphate) tetrasodium is a selective inhibitor of staphylococcal nuclease and tudor domain containing 1 (SND1, the MicroRNA regulatory complex RISC subunit) and [3,5-2H2] tyrosyl nuclease. Thymidine 3',5'-diphosphate tetrasodium has anti-tumor activity and can also be used as a catalyst in biochemical reactions[1][2].

IC50 & Target

Staphylococcal nuclease and tudor domain containing 1, SND1; [3,5-(2)H(2)] Tyrosyl nuclease[1][2]
In Vitro

Thymidine 3',5'-diphosphate tetrasodium (200 µM; 18 h) significantly reduces the expression level of p65 and p65 nuclear translocation in WT and Alb/SND1 (specific transgenic mouse overexpressing SND1) hepatocytes by inhibiting staphylococcal nuclease and tudor domain containing 1 (SND1) enzyme activity. Thymidine 3',5'-diphosphate tetrasodium inhibits the spherical formation of WT and Alb/SND1 hepatocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thymidine 3',5'-diphosphate tetrasodium Related Antibodies
In Vivo

Thymidine 3',5'-diphosphate tetrasodium (0.8 mg/kg; i.p.; twice a week for 4 weeks) has insignificant effect on serum liver enzymes (AST, ALT, AP), total protein (TP), albumin (Alb), and globulin (Glo) in WT B6/CBA mice[1].
Thymidine 3',5'-diphosphate tetrasodium (0.8 mg/kg and 1.6 mg/kg; i.v.; twice a week for 4 weeks) significantly inhibits tumor growth in WT B6/CBA mice[1].
Thymidine 3',5'-diphosphate tetrasodium (0.8, 0.16 and 0.32 mg/kg; s.c.; twice a week for 4 weeks) inhibits tumor growth, inflammatory reaction and the expression of tumor initiating cells (TIC) markers in adult male NSG mice. Thymidine 3',5'-diphosphate tetrasodium up-regulates the expression of PTEN, TGFBR2 and CDKN1C apoptosis and selective tumor suppressor genes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 2 months old WT B6/CBA mice[1].
Dosage: 0.8 mg/kg.
Administration: Intraperitoneal injection; twice a week for 4 weeks.
Result: Had insignificant effect on serum liver enzymes, total protein, albumin and globulin and showed biosafety.
Animal Model: NSG mice[1].
Dosage: 0.8, 0.16 or 0.32 mg/kg.
Administration: Intravenous injection or subcutaneous injection; twice a week for 4 weeks.
Result: Inhibited tumor growth, showed antitumor activity and immunomodulatory effects.
Molecular Weight

490.12

Formula

C10H12N2Na4O11P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC(N([C@@H](C[C@@H]2OP(O[Na])(O[Na])=O)O[C@@H]2COP(O[Na])(O[Na])=O)C=C1C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (102.02 mM; Need ultrasonic)

DMSO : 3.33 mg/mL (6.79 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0403 mL 10.2016 mL 20.4032 mL
5 mM 0.4081 mL 2.0403 mL 4.0806 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.0403 mL 10.2016 mL 20.4032 mL 51.0079 mL
5 mM 0.4081 mL 2.0403 mL 4.0806 mL 10.2016 mL
H2O 10 mM 0.2040 mL 1.0202 mL 2.0403 mL 5.1008 mL
15 mM 0.1360 mL 0.6801 mL 1.3602 mL 3.4005 mL
20 mM 0.1020 mL 0.5101 mL 1.0202 mL 2.5504 mL
25 mM 0.0816 mL 0.4081 mL 0.8161 mL 2.0403 mL
30 mM 0.0680 mL 0.3401 mL 0.6801 mL 1.7003 mL
40 mM 0.0510 mL 0.2550 mL 0.5101 mL 1.2752 mL
50 mM 0.0408 mL 0.2040 mL 0.4081 mL 1.0202 mL
60 mM 0.0340 mL 0.1700 mL 0.3401 mL 0.8501 mL
80 mM 0.0255 mL 0.1275 mL 0.2550 mL 0.6376 mL
100 mM 0.0204 mL 0.1020 mL 0.2040 mL 0.5101 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Thymidine 3',5'-diphosphate tetrasodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thymidine 3',5'-diphosphate tetrasodium118675-87-9Deoxythymidine 3′,5′-diphosphate tetrasodiumpdTp tetrasodiumApoptosisMicroRNAmiRNASND1NSG miceHepatocellular carcinoma tumorAnti-tumorInhibitorinhibitorinhibit

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