Thymidine 3',5'-diphosphate tetrasodium
Based on 1 Customer Validation
Thymidine 3',5'-diphosphate (Deoxythymidine 3′,5′-diphosphate) tetrasodium is a selective inhibitor of staphylococcal nuclease and tudor domain containing 1 (SND1, the MicroRNA regulatory complex RISC subunit) and [3,5-2H2] tyrosyl nuclease. Thymidine 3',5'-diphosphate tetrasodium has anti-tumor activity and can also be used as a catalyst in biochemical reactions.
For research use only. We do not sell to patients.
- Purity: 98.75%
- CAS No.: 118675-87-9
- Formula: C10H12N2Na4O11P2
- Molecular Weight:490.12
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Staphylococcal nuclease and tudor domain containing 1, SND1; [3,5-(2)H(2)] Tyrosyl nuclease[1][2]
Thymidine 3',5'-diphosphate tetrasodium (200 µM; 18 h) significantly reduces the expression level of p65 and p65 nuclear translocation in WT and Alb/SND1 (specific transgenic mouse overexpressing SND1) hepatocytes by inhibiting staphylococcal nuclease and tudor domain containing 1 (SND1) enzyme activity. Thymidine 3',5'-diphosphate tetrasodium inhibits the spherical formation of WT and Alb/SND1 hepatocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Thymidine 3',5'-diphosphate tetrasodium (0.8 mg/kg and 1.6 mg/kg; i.v.; twice a week for 4 weeks) significantly inhibits tumor growth in WT B6/CBA mice[1].
Thymidine 3',5'-diphosphate tetrasodium (0.8, 0.16 and 0.32 mg/kg; s.c.; twice a week for 4 weeks) inhibits tumor growth, inflammatory reaction and the expression of tumor initiating cells (TIC) markers in adult male NSG mice. Thymidine 3',5'-diphosphate tetrasodium up-regulates the expression of PTEN, TGFBR2 and CDKN1C apoptosis and selective tumor suppressor genes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:2 months old WT B6/CBA mice[1].
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Dosage:0.8 mg/kg.
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Administration:Intraperitoneal injection; twice a week for 4 weeks.
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Result:Had insignificant effect on serum liver enzymes, total protein, albumin and globulin and showed biosafety.
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Animal Model:NSG mice[1].
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Dosage:0.8, 0.16 or 0.32 mg/kg.
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Administration:Intravenous injection or subcutaneous injection; twice a week for 4 weeks.
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Result:Inhibited tumor growth, showed antitumor activity and immunomodulatory effects.
Chemical Information
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CAS No. 118675-87-9
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Appearance Solid
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Molecular Weight 490.12
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Formula C10H12N2Na4O11P2
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Color White to off-white
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SMILES
O=C1NC(N([C@@H](C[C@@H]2OP(O[Na])(O[Na])=O)O[C@@H]2COP(O[Na])(O[Na])=O)C=C1C)=O
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Synonyms
Deoxythymidine 3′,5′-diphosphate tetrasodium; pdTp tetrasodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 50 mg/mL (102.02 mM; Need ultrasonic)
DMSO : 3.33 mg/mL (6.79 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.0403 mL | 10.2016 mL | 20.4032 mL | 51.0079 mL |
| 5 mM | 0.4081 mL | 2.0403 mL | 4.0806 mL | 10.2016 mL | |
| H2O | 10 mM | 0.2040 mL | 1.0202 mL | 2.0403 mL | 5.1008 mL |
| 15 mM | 0.1360 mL | 0.6801 mL | 1.3602 mL | 3.4005 mL | |
| 20 mM | 0.1020 mL | 0.5101 mL | 1.0202 mL | 2.5504 mL | |
| 25 mM | 0.0816 mL | 0.4081 mL | 0.8161 mL | 2.0403 mL | |
| 30 mM | 0.0680 mL | 0.3401 mL | 0.6801 mL | 1.7003 mL | |
| 40 mM | 0.0510 mL | 0.2550 mL | 0.5101 mL | 1.2752 mL | |
| 50 mM | 0.0408 mL | 0.2040 mL | 0.4081 mL | 1.0202 mL | |
| 60 mM | 0.0340 mL | 0.1700 mL | 0.3401 mL | 0.8501 mL | |
| 80 mM | 0.0255 mL | 0.1275 mL | 0.2550 mL | 0.6376 mL | |
| 100 mM | 0.0204 mL | 0.1020 mL | 0.2040 mL | 0.5101 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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