Palifosfamide tromethamine
Based on 2 publication(s) in Google Scholar
Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.
For research use only. We do not sell to patients.
- Purity: 98.74%
- CAS No.: 1070409-31-2
- Formula: C8H22Cl2N3O5P
- Molecular Weight:342.16
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Palifosfamide tromethamine
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Biological Activity
Chemical Information
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CAS No. 1070409-31-2
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Appearance Solid-Liquid Mixture
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Molecular Weight 342.16
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Formula C8H22Cl2N3O5P
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Color Colorless to off-white
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SMILES
O=P(NCCCl)(NCCCl)O.NC(CO)(CO)CO
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Synonyms
Isophosphoramide mustard tromethamine; IPM tromethamine; ZIO-201 tromethamine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Acta Pharmacol Sin
Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway. [Abstract]2021 Jan;42(1):108-114. PMID: 32398685 -
J Mol Med (Berl)
2019 Aug;97(8):1183-1193. PMID: 31201471
Solvent & Solubility
DMSO : ≥ 100 mg/mL (292.26 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9226 mL | 14.6130 mL | 29.2261 mL | 73.0652 mL |
| 5 mM | 0.5845 mL | 2.9226 mL | 5.8452 mL | 14.6130 mL | |
| 10 mM | 0.2923 mL | 1.4613 mL | 2.9226 mL | 7.3065 mL | |
| 15 mM | 0.1948 mL | 0.9742 mL | 1.9484 mL | 4.8710 mL | |
| 20 mM | 0.1461 mL | 0.7307 mL | 1.4613 mL | 3.6533 mL | |
| 25 mM | 0.1169 mL | 0.5845 mL | 1.1690 mL | 2.9226 mL | |
| 30 mM | 0.0974 mL | 0.4871 mL | 0.9742 mL | 2.4355 mL | |
| 40 mM | 0.0731 mL | 0.3653 mL | 0.7307 mL | 1.8266 mL | |
| 50 mM | 0.0585 mL | 0.2923 mL | 0.5845 mL | 1.4613 mL | |
| 60 mM | 0.0487 mL | 0.2436 mL | 0.4871 mL | 1.2178 mL | |
| 80 mM | 0.0365 mL | 0.1827 mL | 0.3653 mL | 0.9133 mL | |
| 100 mM | 0.0292 mL | 0.1461 mL | 0.2923 mL | 0.7307 mL |
Palifosfamide tromethamine Related Classifications
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