2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. Palifosfamide tromethamine

Palifosfamide tromethamine  (Synonyms: Isophosphoramide mustard tromethamine; IPM tromethamine; ZIO-201 tromethamine)

Cat. No.: HY-114577 Purity: 98.74%
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Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.

For research use only. We do not sell to patients.

Palifosfamide tromethamine

Palifosfamide tromethamine Chemical Structure

CAS No. : 1070409-31-2

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Based on 2 publication(s) in Google Scholar

Other Forms of Palifosfamide tromethamine:

Palifosfamide tromethamine Related Antibodies

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Description

Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.

Molecular Weight

342.16

Formula

C8H22Cl2N3O5P
CAS No.
Appearance

Solid-Liquid Mixture

Color

Colorless to off-white

SMILES

O=P(NCCCl)(NCCCl)O.NC(CO)(CO)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (292.26 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9226 mL 14.6130 mL 29.2261 mL
5 mM 0.5845 mL 2.9226 mL 5.8452 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9226 mL 14.6130 mL 29.2261 mL 73.0652 mL
5 mM 0.5845 mL 2.9226 mL 5.8452 mL 14.6130 mL
10 mM 0.2923 mL 1.4613 mL 2.9226 mL 7.3065 mL
15 mM 0.1948 mL 0.9742 mL 1.9484 mL 4.8710 mL
20 mM 0.1461 mL 0.7307 mL 1.4613 mL 3.6533 mL
25 mM 0.1169 mL 0.5845 mL 1.1690 mL 2.9226 mL
30 mM 0.0974 mL 0.4871 mL 0.9742 mL 2.4355 mL
40 mM 0.0731 mL 0.3653 mL 0.7307 mL 1.8266 mL
50 mM 0.0585 mL 0.2923 mL 0.5845 mL 1.4613 mL
60 mM 0.0487 mL 0.2436 mL 0.4871 mL 1.2178 mL
80 mM 0.0365 mL 0.1827 mL 0.3653 mL 0.9133 mL
100 mM 0.0292 mL 0.1461 mL 0.2923 mL 0.7307 mL
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Palifosfamide tromethamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Palifosfamide1070409-31-2Isophosphoramide mustardIPMZIO-201ZIO201ZIO 201DNA Alkylator/CrosslinkerInhibitorinhibitorinhibit

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