DL-Sulforaphane N-acetyl-L-cysteine
Based on 1 Customer Validation
DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is an orally active HDAC inhibitor and metabolite of sulforaphane (HY-13755) with longer half-life and better blood-brain barrier permeability. DL-Sulforaphane N-acetyl-L-cysteine activates autophagy-mediated downregulation of α-tubulin expression through the ERK pathway and can be used in cancer research.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 334829-66-2
- Formula: C11H20N2O4S3
- Molecular Weight:340.48
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-13755
Sulforaphane
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HY-132242R
DL-Sulforaphane N-acetyl-L-cysteine (Standard)
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HY-124087
(±)-2-Propyl-4-pentenoic acid
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HY-G0007
Omeprazole sulfone
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HY-10585S
Valproic acid-d4
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HY-113848
AEM1
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HY-B1189S
Meglutol-d3
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HY-124087R
(±)-2-Propyl-4-pentenoic acid (Standard)
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HY-G0007R
Omeprazole sulfone (Standard)
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HY-113327S
1,3,7-Trimethyluric acid-d9
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LoVo | IC50 |
20.5 μM
Compound: NAC-SFN
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Antiproliferative activity against human LoVo cells after 72 hrs by SRB assay
Antiproliferative activity against human LoVo cells after 72 hrs by SRB assay
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[PMID: 29945793] |
SFN-NAC (24 h) decreases cell viability, with IC50 values of 60.08 μM for HA, 35.20 μM for U87MG, 39.11 μM for U373MG, and 36.20 μM for the U87/TR cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U87MG and U373MG cells
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Concentration:0, 30 μM
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Incubation Time:24 h
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Result:Induced cell-cycle arrest in the G2/M phase and triggered apoptosis at the same time.
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Cell Line:U87MG and U373MG cells
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Concentration:0, 10, 20, 30, 40, 50μM
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Incubation Time:24 h
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Result:Activated ERK1/2 (Thr202/Tyr204), downregulated α-tubulin, and induced autophagy in a dose-dependent manner.
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Cell Line:HA, U87MG, U373MG and U87/TR cells
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Concentration:0, 10, 20, 30, 40, 50, 60, 70, 80, 90 μM for HA and U87MG cells or 0, 10, 20, 30, 40, 50, 60 μM for U373MG and U87/TR cells
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Incubation Time:24 h
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Result:Decreased the cell viability of these cell lines in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:mice[2]
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Dosage:10 μmol
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Administration:Oral gavage; 6 h; single dose
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Result:Significantly inhibited HDAC activity in mouse colon mucosa.
Chemical Information
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CAS No. 334829-66-2
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Appearance Solid
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Molecular Weight 340.48
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Formula C11H20N2O4S3
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Color White to off-white
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SMILES
CS(CCCCNC(SC[C@@H](C(O)=O)NC(C)=O)=S)=O
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Synonyms
SFN-NAC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 10 mg/mL (29.37 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9370 mL | 14.6851 mL | 29.3703 mL | 73.4257 mL |
| 5 mM | 0.5874 mL | 2.9370 mL | 5.8741 mL | 14.6851 mL | |
| 10 mM | 0.2937 mL | 1.4685 mL | 2.9370 mL | 7.3426 mL | |
| 15 mM | 0.1958 mL | 0.9790 mL | 1.9580 mL | 4.8950 mL | |
| 20 mM | 0.1469 mL | 0.7343 mL | 1.4685 mL | 3.6713 mL | |
| 25 mM | 0.1175 mL | 0.5874 mL | 1.1748 mL | 2.9370 mL |
DL-Sulforaphane N-acetyl-L-cysteine Related Classifications
HY-132242 Related Classifications
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