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  3. Sodium 2-oxopropanoate

Sodium 2-oxopropanoate (Synonyms: Sodium pyruvate)

Cat. No.: HY-W015913
Handling Instructions

Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS.

For research use only. We do not sell to patients.

Sodium 2-oxopropanoate Chemical Structure

Sodium 2-oxopropanoate Chemical Structure

CAS No. : 113-24-6

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Based on 1 publication(s) in Google Scholar

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Description

Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[1][2].

IC50 & Target

Microbial Metabolite

 

In Vitro

In the process of scavenging hydrogen peroxide, Sodium 2-oxopropanoate (Sodium pyruvate) is decarboxylated to lactate and hence diverted away from aerobic metabolism and further ROS generation. Under conditions in which pyruvate stimulated JNK1 activity, both mitochondrial and cytosolic ROS levels rose. An increase in JNK1 activity in a variety of different cell types over a range of pyruvate concentrations are observed[1].
Sodium 2-oxopropanoate (Sodium pyruvate) is an effective scavenger of H2O2 as well as of O2▪-, thereby protecting the lens against oxidative stress and consequent cataract formation, under in vitro as well as in vivo conditions, Sodium 2-oxopropanoate has also been shown to protect the lens proteins against glycation by competitively inhibiting the initial reaction between the sugar carbonyl and the protein -NH2[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Neonatal rats are given a bolus of Sodium 2-oxopropanoate (Sodium pyruvate; 0.1-10 g/kg), and 1 h later, levels of JNK1 activity were determined in liver extracts. Sodium 2-oxopropanoate (Sodium pyruvate) addition resulted in a significant increase in JNK1 activity. Analysis of serum levels of Sodium 2-oxopropanoate in neonatal rats revealed that baseline levels of pyruvate are 0.30 mM. At the time of sacrifice, following the largest dose of Sodium 2-oxopropanoate, serum levels rose approximately sixfold to 1.84 mM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

110.04

Formula

C₃H₃NaO₃

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (1135.95 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.0876 mL 45.4380 mL 90.8760 mL
5 mM 1.8175 mL 9.0876 mL 18.1752 mL
10 mM 0.9088 mL 4.5438 mL 9.0876 mL
*Please refer to the solubility information to select the appropriate solvent.
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Sodium 2-oxopropanoate
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