Pyruvic acid sodium
Based on 21 publication(s) in Google Scholar
Pyruvic acid sodium is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.
For research use only. We do not sell to patients.
- Purity : 99.86%
- CAS No.: 113-24-6
- Formula: C3H3NaO3
- Molecular Weight:110.04
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Pyruvic acid sodium
More- Cancer Commun (Lond). 2025 May 29. [Abstract]
- Bioact Mater. 2025 Feb 13:48:55-70. [Abstract]
- Cancer Res. 2026 Feb 9. [Abstract]
- ACS Nano. 2024 Aug 20;18(33):21855-21872. [Abstract]
- Redox Biol. 2024 May:71:103112. [Abstract]
- Mol Cell. 2026 Sep 3;86(17):3529-3544.e9.
- Adv Sci (Weinh). 2026 Aug 3:e76963.
- Adv Sci (Weinh). 2024 Oct;11(38):e2406333. [Abstract]
- Cell Death Dis. 2023 Apr 6;14(4):246. [Abstract]
- Acta Pharmacol Sin. 2026 May 18. [Abstract]
- Cell Prolif. 2023 Sep;56(9):e13442. [Abstract]
- J Agric Food Chem. 2025 Aug 13;73(32):20385-20395. [Abstract]
- J Hypertens. 2024 Aug 1;42(8):1427-1439. [Abstract]
- Int Immunopharmacol. 2023 Jul:120:110292. [Abstract]
- Phenomics. 2026 Sep 7.
- Toxicology. 2025 Oct 13:519:154309. [Abstract]
- Brain Res Bull. 2026 Oct 1:244:112053.
- J Virol. 2024 Mar 19;98(3):e0175123. [Abstract]
- Bone. 2026 Jun:207:117859. [Abstract]
- Cell Biochem Biophys. 2025 Mar;83(1):879-891. [Abstract]
- bioRxiv. 2025 Aug 22.
Customer Validation & Images
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
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WB
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Cell Imaging/Staining
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Cell Proliferation/Viability Assay
All Endogenous Metabolite Isoforms
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Biological Activity
Description
IC50 & Target
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Microbial Metabolite |
Human Endogenous Metabolite |
In Vitro
Pyruvic acid (0.1-1 mM, 24 h) sodium inhibits mitochondrial damage, exhibits antioxidant and protective effects against Cu2+, Zn2+ or H2O2 induced neurotoxicity in GT1-7 and N-2A cells[2][3].
Pyruvic acid (1-5 mM, 48 h) sodium promotes the differentiation of RAW264.7 cells into osteoclasts[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:N-2A cell
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Concentration:0.1-1 mM
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Incubation Time:24 h
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Result:Maintained cell viability.
Chemical Information
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CAS No. 113-24-6
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Appearance Solid
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Molecular Weight 110.04
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Formula C3H3NaO3
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Color White to light yellow
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SMILES
CC(C(O[Na])=O)=O
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Synonyms
Sodium 2-oxopropanoate; Acetylformic acid sodium
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (21)
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Journal Impact Factor
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Most Recent
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Cancer Commun (Lond)
Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-hyperactivated intrahepatic cholangiocarcinoma. [Abstract]2025 May 29. PMID: 40443016
Pyruvic acid sodium purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2025 May 29. [Abstract]
Measurements of lipid peroxidation and cell death in HuCCT‐1‐WT or PCK1S90A HuCCT‐1 after 36 h of indicated treatments (10 mmol/L glucose; 10 mmol/L Pyruvic acid sodium; 10 mmol/L Nala), followed by exposure to 10 µmol/L RSL3 for an additional 36 h.
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Bioact Mater
cGAMP-targeting injectable hydrogel system promotes periodontal restoration by alleviating cGAS-STING pathway activation. [Abstract]2025 Feb 13:48:55-70. PMID: 40303968 -
Cancer Res
The Farnesyl Transferase Inhibitor Darlifarnib (KO-2806) Resensitizes Relapsing Tumors to RAS Inhibition. [Abstract]2026 Feb 9. PMID: 41661652 -
ACS Nano
Enzyme-Dynamic Extracellular Vesicles for Metalloimmunotherapy of Malignant Pleural Effusions. [Abstract]2024 Aug 20;18(33):21855-21872. PMID: 39109520 -
Redox Biol
Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hub. [Abstract]2024 May:71:103112. PMID: 38461791 -
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Adv Sci (Weinh)
Lactylated Apolipoprotein C-II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis. [Abstract]2024 Oct;11(38):e2406333. PMID: 38981044 -
Cell Death Dis
2023 Apr 6;14(4):246. PMID: 37024456 -
Acta Pharmacol Sin
Few-shot learning-driven discovery of Lutein suppresses Th1-mediated inflammation via glucose metabolism. [Abstract]2026 May 18. PMID: 42144445 -
Cell Prolif
2023 Sep;56(9):e13442. PMID: 37086012 -
J Agric Food Chem
Zearalenone Regulates Energy Metabolism and Proliferation of Goat Endometrial Epithelial Cells through Estrogen Receptor 1. [Abstract]2025 Aug 13;73(32):20385-20395. PMID: 40762316
Pyruvic acid sodium purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2025 Aug 13;73(32):20385-20395. [Abstract]
EDU analysis to assess the proliferation ability of goat EECs under Pyruvic acid sodium (PA: 100 μg/mL) with or without OMA1 plasmid.
Pyruvic acid sodium purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2025 Aug 13;73(32):20385-20395. [Abstract]
Effect of OMA1 overexpression on cell proliferation and mitochondrial structure and function in goat endometrial epithelial cells under Pyruvic acid sodium (100 μg/mL; 48 h) treatment. Western blot analysis of the expression levels of OPA1, MFN1, and MFN2.
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J Hypertens
Asprosin contributes to vascular remodeling in hypertensive rats via superoxide signaling. [Abstract]2024 Aug 1;42(8):1427-1439. PMID: 38690935 -
Int Immunopharmacol
2023 Jul:120:110292. PMID: 37182452 -
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Toxicology
2025 Oct 13:519:154309. PMID: 41093097
Pyruvic acid sodium purchased from MedChemExpress. Usage Cited in: Toxicology. 2025 Oct 13:519:154309. [Abstract]
Renal tubular epithelial cells were treated with DMSO, 3 mM Pyruvic acid sodium, and 25 μM lovastatin (with or without 3 mM Pyruvic acid sodium) for 48 hours. ROS generation of the microarray epithelial cells was assessed by DCFH-DA staining.
Pyruvic acid sodium purchased from MedChemExpress. Usage Cited in: Toxicology. 2025 Oct 13:519:154309. [Abstract]
Renal tubular epithelial cells were treated with DMSO, 3 mM Pyruvic acid sodium, and 25 μM lovastatin (with or without 3 mM Pyruvic acid sodium) for 48 hours. Damage to renal tubular epithelial cells on the chip was measured using the LDH assay.
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J Virol
2024 Mar 19;98(3):e0175123. PMID: 38319105 -
Bone
Sympathetic overactivity-induced type H endothelial cell senescence contributes to the impairment of vascularized osteogenesis by PKM2-mediated glycolysis in preclinical stages of Alzheimer's mice. [Abstract]2026 Jun:207:117859. PMID: 41833832 -
Cell Biochem Biophys
TREM2 Impairs Glycolysis to Interrupt Microglial M1 Polarization and Inflammation via JAK2/STAT3 Axis. [Abstract]2025 Mar;83(1):879-891. PMID: 39240442 -
Solvent & Solubility
In Vitro:
H2O : 100 mg/mL (908.76 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (454.38 mM); Clear solution; Need ultrasonic
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Kładna A, et al. Reactivity of pyruvic acid and its derivatives towards reactive oxygen species. Luminescence. 2015 Nov;30(7):1153-8. [Content Brief]
[3]. Tanaka KI, et al., Pyruvic acid prevents Cu2+/Zn2+-induced neurotoxicity by suppressing mitochondrial injury. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1335-1341. [Content Brief]
[4]. Mazzio EA, et al., Cytoprotection of pyruvic acid and reduced beta-nicotinamide adenine dinucleotide against hydrogen peroxide toxicity in neuroblastoma cells. Neurochem Res. 2003 May;28(5):733-41. [Content Brief]
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Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 9.0876 mL | 45.4380 mL | 90.8760 mL | 227.1901 mL |
| 5 mM | 1.8175 mL | 9.0876 mL | 18.1752 mL | 45.4380 mL | |
| 10 mM | 0.9088 mL | 4.5438 mL | 9.0876 mL | 22.7190 mL | |
| 15 mM | 0.6058 mL | 3.0292 mL | 6.0584 mL | 15.1460 mL | |
| 20 mM | 0.4544 mL | 2.2719 mL | 4.5438 mL | 11.3595 mL | |
| 25 mM | 0.3635 mL | 1.8175 mL | 3.6350 mL | 9.0876 mL | |
| 30 mM | 0.3029 mL | 1.5146 mL | 3.0292 mL | 7.5730 mL | |
| 40 mM | 0.2272 mL | 1.1360 mL | 2.2719 mL | 5.6798 mL | |
| 50 mM | 0.1818 mL | 0.9088 mL | 1.8175 mL | 4.5438 mL | |
| 60 mM | 0.1515 mL | 0.7573 mL | 1.5146 mL | 3.7865 mL | |
| 80 mM | 0.1136 mL | 0.5680 mL | 1.1360 mL | 2.8399 mL | |
| 100 mM | 0.0909 mL | 0.4544 mL | 0.9088 mL | 2.2719 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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