2. NF-κB Immunology/Inflammation Metabolic Enzyme/Protease
  3. Reactive Oxygen Species Endogenous Metabolite
  4. Sodium 2-oxopropanoate

Sodium 2-oxopropanoate  (Synonyms: Sodium pyruvate)

Cat. No.: HY-W015913 Purity: 99.86%
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Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS.

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Sodium 2-oxopropanoate Chemical Structure

Sodium 2-oxopropanoate Chemical Structure

CAS No. : 113-24-6

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Based on 5 publication(s) in Google Scholar

Other Forms of Sodium 2-oxopropanoate:

Sodium 2-oxopropanoate Related Antibodies

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Description

Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[1][2].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

In the process of scavenging hydrogen peroxide, Sodium 2-oxopropanoate (Sodium pyruvate) is decarboxylated to lactate and hence diverted away from aerobic metabolism and further ROS generation. Under conditions in which pyruvate stimulated JNK1 activity, both mitochondrial and cytosolic ROS levels rose. An increase in JNK1 activity in a variety of different cell types over a range of pyruvate concentrations are observed[1].
Sodium 2-oxopropanoate (Sodium pyruvate) is an effective scavenger of H2O2 as well as of O2·-, thereby protecting the lens against oxidative stress and consequent cataract formation, under in vitro as well as in vivo conditions, Sodium 2-oxopropanoate has also been shown to protect the lens proteins against glycation by competitively inhibiting the initial reaction between the sugar carbonyl and the protein -NH2[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium 2-oxopropanoate Related Antibodies
In Vivo

Neonatal rats are given a bolus of Sodium 2-oxopropanoate (Sodium pyruvate; 0.1-10 g/kg), and 1 h later, levels of JNK1 activity were determined in liver extracts. Sodium 2-oxopropanoate (Sodium pyruvate) addition resulted in a significant increase in JNK1 activity. Analysis of serum levels of Sodium 2-oxopropanoate in neonatal rats revealed that baseline levels of pyruvate are 0.30 mM. At the time of sacrifice, following the largest dose of Sodium 2-oxopropanoate, serum levels rose approximately sixfold to 1.84 mM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

110.04

Formula

C3H3NaO3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(C(O[Na])=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (908.76 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.0876 mL 45.4380 mL 90.8760 mL
5 mM 1.8175 mL 9.0876 mL 18.1752 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (454.38 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.86%

COA (249 KB) HNMR (105 KB) RP-HPLC (256 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 9.0876 mL 45.4380 mL 90.8760 mL 227.1901 mL
5 mM 1.8175 mL 9.0876 mL 18.1752 mL 45.4380 mL
10 mM 0.9088 mL 4.5438 mL 9.0876 mL 22.7190 mL
15 mM 0.6058 mL 3.0292 mL 6.0584 mL 15.1460 mL
20 mM 0.4544 mL 2.2719 mL 4.5438 mL 11.3595 mL
25 mM 0.3635 mL 1.8175 mL 3.6350 mL 9.0876 mL
30 mM 0.3029 mL 1.5146 mL 3.0292 mL 7.5730 mL
40 mM 0.2272 mL 1.1360 mL 2.2719 mL 5.6798 mL
50 mM 0.1818 mL 0.9088 mL 1.8175 mL 4.5438 mL
60 mM 0.1515 mL 0.7573 mL 1.5146 mL 3.7865 mL
80 mM 0.1136 mL 0.5680 mL 1.1360 mL 2.8399 mL
100 mM 0.0909 mL 0.4544 mL 0.9088 mL 2.2719 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sodium 2-oxopropanoate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium 2-oxopropanoate113-24-6Sodium pyruvateReactive Oxygen SpeciesEndogenous MetaboliteGlycolysisGlucoseROSfreeradicalscavengerInhibitorinhibitorinhibit

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