Pyruvic acid sodium
Based on 18 publication(s) in Google Scholar
Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS.
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- Reinheit : 99.86%
- CAS. Nr.: 113-24-6
- Formel: C3H3NaO3
- Molecular Weight:110.04
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
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Publications Citing Use of MedChemExpress (MCE) Pyruvic acid sodium
More- Cancer Commun (Lond). 2025 May 29. [Abstract]
- Bioact Mater. 2025 Feb 13:48:55-70. [Abstract]
- Cancer Res. 2026 Feb 9. [Abstract]
- ACS Nano. 2024 Aug 20;18(33):21855-21872. [Abstract]
- Redox Biol. 2024 May:71:103112. [Abstract]
- Adv Sci (Weinh). 2024 Oct;11(38):e2406333. [Abstract]
- Cell Death Dis. 2023 Apr 6;14(4):246. [Abstract]
- Acta Pharmacol Sin. 2026 May 18. [Abstract]
- Cell Prolif. 2023 Sep;56(9):e13442. [Abstract]
- J Agric Food Chem. 2025 Aug 13;73(32):20385-20395. [Abstract]
- J Hypertens. 2024 Aug 1;42(8):1427-1439. [Abstract]
- Int Immunopharmacol. 2023 Jul:120:110292. [Abstract]
- Toxicology. 2025 Oct 13:519:154309. [Abstract]
- Brain Res Bull. 2026 Oct 1:244:112053.
- J Virol. 2024 Mar 19;98(3):e0175123. [Abstract]
- Bone. 2026 Jun:207:117859. [Abstract]
- Cell Biochem Biophys. 2025 Mar;83(1):879-891. [Abstract]
- bioRxiv. 2025 Aug 22.
Customer Validation & Images
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
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WB
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Cell Imaging/Staining
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Cell Proliferation/Viability Assay
Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
Beschreibung
IC50 & Target
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Microbial Metabolite |
Human Endogenous Metabolite |
In Vitro
In the process of scavenging hydrogen peroxide, Sodium 2-oxopropanoate (Sodium pyruvate) is decarboxylated to lactate and hence diverted away from aerobic metabolism and further ROS generation. Under conditions in which pyruvate stimulated JNK1 activity, both mitochondrial and cytosolic ROS levels rose. An increase in JNK1 activity in a variety of different cell types over a range of pyruvate concentrations are observed[1].
Sodium 2-oxopropanoate (Sodium pyruvate) is an effective scavenger of H2O2 as well as of O2·-, thereby protecting the lens against oxidative stress and consequent cataract formation, under in vitro as well as in vivo conditions, Sodium 2-oxopropanoate has also been shown to protect the lens proteins against glycation by competitively inhibiting the initial reaction between the sugar carbonyl and the protein -NH2[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 113-24-6
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Appearance Solid
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Molecular Weight 110.04
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Formel C3H3NaO3
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Color White to light yellow
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SMILES
CC(C(O[Na])=O)=O
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Synonyms
Sodium 2-oxopropanoate; Acetylformic acid sodium
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (18)
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Journal Impact Factor
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Most Recent
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Cancer Commun (Lond)
Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-hyperactivated intrahepatic cholangiocarcinoma. [Abstract]2025 May 29. PMID: 40443016
Pyruvic acid sodium purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2025 May 29. [Abstract]
Measurements of lipid peroxidation and cell death in HuCCT‐1‐WT or PCK1S90A HuCCT‐1 after 36 h of indicated treatments (10 mmol/L glucose; 10 mmol/L Pyruvic acid sodium; 10 mmol/L Nala), followed by exposure to 10 µmol/L RSL3 for an additional 36 h.
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Bioact Mater
cGAMP-targeting injectable hydrogel system promotes periodontal restoration by alleviating cGAS-STING pathway activation. [Abstract]2025 Feb 13:48:55-70. PMID: 40303968 -
Cancer Res
The Farnesyl Transferase Inhibitor Darlifarnib (KO-2806) Resensitizes Relapsing Tumors to RAS Inhibition. [Abstract]2026 Feb 9. PMID: 41661652 -
ACS Nano
Enzyme-Dynamic Extracellular Vesicles for Metalloimmunotherapy of Malignant Pleural Effusions. [Abstract]2024 Aug 20;18(33):21855-21872. PMID: 39109520 -
Redox Biol
Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hub. [Abstract]2024 May:71:103112. PMID: 38461791 -
Adv Sci (Weinh)
Lactylated Apolipoprotein C-II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis. [Abstract]2024 Oct;11(38):e2406333. PMID: 38981044 -
Cell Death Dis
2023 Apr 6;14(4):246. PMID: 37024456 -
Acta Pharmacol Sin
Few-shot learning-driven discovery of Lutein suppresses Th1-mediated inflammation via glucose metabolism. [Abstract]2026 May 18. PMID: 42144445 -
Cell Prolif
2023 Sep;56(9):e13442. PMID: 37086012 -
J Agric Food Chem
Zearalenone Regulates Energy Metabolism and Proliferation of Goat Endometrial Epithelial Cells through Estrogen Receptor 1. [Abstract]2025 Aug 13;73(32):20385-20395. PMID: 40762316
Pyruvic acid sodium purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2025 Aug 13;73(32):20385-20395. [Abstract]
EDU analysis to assess the proliferation ability of goat EECs under Pyruvic acid sodium (PA: 100 μg/mL) with or without OMA1 plasmid.
Pyruvic acid sodium purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2025 Aug 13;73(32):20385-20395. [Abstract]
Effect of OMA1 overexpression on cell proliferation and mitochondrial structure and function in goat endometrial epithelial cells under Pyruvic acid sodium (100 μg/mL; 48 h) treatment. Western blot analysis of the expression levels of OPA1, MFN1, and MFN2.
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J Hypertens
Asprosin contributes to vascular remodeling in hypertensive rats via superoxide signaling. [Abstract]2024 Aug 1;42(8):1427-1439. PMID: 38690935 -
Int Immunopharmacol
2023 Jul:120:110292. PMID: 37182452 -
Toxicology
2025 Oct 13:519:154309. PMID: 41093097
Pyruvic acid sodium purchased from MedChemExpress. Usage Cited in: Toxicology. 2025 Oct 13:519:154309. [Abstract]
Renal tubular epithelial cells were treated with DMSO, 3 mM Pyruvic acid sodium, and 25 μM lovastatin (with or without 3 mM Pyruvic acid sodium) for 48 hours. ROS generation of the microarray epithelial cells was assessed by DCFH-DA staining.
Pyruvic acid sodium purchased from MedChemExpress. Usage Cited in: Toxicology. 2025 Oct 13:519:154309. [Abstract]
Renal tubular epithelial cells were treated with DMSO, 3 mM Pyruvic acid sodium, and 25 μM lovastatin (with or without 3 mM Pyruvic acid sodium) for 48 hours. Damage to renal tubular epithelial cells on the chip was measured using the LDH assay.
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J Virol
2024 Mar 19;98(3):e0175123. PMID: 38319105 -
Bone
Sympathetic overactivity-induced type H endothelial cell senescence contributes to the impairment of vascularized osteogenesis by PKM2-mediated glycolysis in preclinical stages of Alzheimer's mice. [Abstract]2026 Jun:207:117859. PMID: 41833832 -
Cell Biochem Biophys
TREM2 Impairs Glycolysis to Interrupt Microglial M1 Polarization and Inflammation via JAK2/STAT3 Axis. [Abstract]2025 Mar;83(1):879-891. PMID: 39240442 -
Lösungsmittel & Löslichkeit
In Vitro:
H2O : 100 mg/mL (908.76 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (454.38 mM); Clear solution; Need ultrasonic
Protokoll
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ROS/oxidative-stress fluorescent staining
ROS/oxidative-stress fluorescent staining uses cell-permeant fluorogenic probes that become fluorescent after oxidation inside cells or tissues; commonly used examples include DCFH-DA/DCFDA for broad cellular oxidant detection, DHE for superoxide-related signal detection, MitoSOX for mitochondrial superoxide-related signal detection, and CellROX probes for oxidative-stress-associated fluorescence readouts. The assay detects probe oxidation rather than a single ROS species unless the probe and analysis method have been chemically validated for that species. DCFH-DA enters cells, is deacetylated by intracellular esterases to DCFH, and produces fluorescent DCF after oxidation, so the readout is used as an operational measure of total cellular oxidative stress rather than a species-specific ROS measurement. DHE and MitoSOX can report superoxide-related oxidation, but red fluorescence alone can include non-specific ethidium-like oxidation products; HPLC or optimized spectral approaches are
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. S Nemoto, et al. Role for mitochondrial oxidants as regulators of cellular metabolism. Mol Cell Biol. 2000 Oct;20(19):7311-8. [Content Brief]
[2]. W Zhao, et al. Fructose induced deactivation of antioxidant enzymes: preventive effect of pyruvate. Free Radic Res. 2000 Jul;33(1):23-30. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 9.0876 mL | 45.4380 mL | 90.8760 mL | 227.1901 mL |
| 5 mM | 1.8175 mL | 9.0876 mL | 18.1752 mL | 45.4380 mL | |
| 10 mM | 0.9088 mL | 4.5438 mL | 9.0876 mL | 22.7190 mL | |
| 15 mM | 0.6058 mL | 3.0292 mL | 6.0584 mL | 15.1460 mL | |
| 20 mM | 0.4544 mL | 2.2719 mL | 4.5438 mL | 11.3595 mL | |
| 25 mM | 0.3635 mL | 1.8175 mL | 3.6350 mL | 9.0876 mL | |
| 30 mM | 0.3029 mL | 1.5146 mL | 3.0292 mL | 7.5730 mL | |
| 40 mM | 0.2272 mL | 1.1360 mL | 2.2719 mL | 5.6798 mL | |
| 50 mM | 0.1818 mL | 0.9088 mL | 1.8175 mL | 4.5438 mL | |
| 60 mM | 0.1515 mL | 0.7573 mL | 1.5146 mL | 3.7865 mL | |
| 80 mM | 0.1136 mL | 0.5680 mL | 1.1360 mL | 2.8399 mL | |
| 100 mM | 0.0909 mL | 0.4544 mL | 0.9088 mL | 2.2719 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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