2. NF-κB Immunology/Inflammation Metabolic Enzyme/Protease
  3. Reactive Oxygen Species (ROS) Endogenous Metabolite
  4. Pyruvic acid sodium

Pyruvic acid sodium  (Synonyms: Sodium 2-oxopropanoate; Acetylformic acid sodium)

Cat. No.: HY-W015913 Purity: 99.86%
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Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS.

For research use only. We do not sell to patients.

CAS No. : 113-24-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
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Based on 16 publication(s) in Google Scholar

Other Forms of Pyruvic acid sodium:

Pyruvic acid sodium Related Antibodies

Top Publications Citing Use of Products

    Pyruvic acid sodium purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2025 May 29.  [Abstract]

    Measurements of lipid peroxidation and cell death in HuCCT‐1‐WT or PCK1S90A HuCCT‐1 after 36 h of indicated treatments (10 mmol/L glucose; 10 mmol/L Pyruvic acid sodium; 10 mmol/L Nala), followed by exposure to 10 µmol/L RSL3 for an additional 36 h.

    Pyruvic acid sodium purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2025 Aug 13;73(32):20385-20395.  [Abstract]

    EDU analysis to assess the proliferation ability of goat EECs under Pyruvic acid sodium (PA: 100 μg/mL) with or without OMA1 plasmid.

    Pyruvic acid sodium purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2025 Aug 13;73(32):20385-20395.  [Abstract]

    Effect of OMA1 overexpression on cell proliferation and mitochondrial structure and function in goat endometrial epithelial cells under Pyruvic acid sodium (100 μg/mL; 48 h) treatment. Western blot analysis of the expression levels of OPA1, MFN1, and MFN2.

    Pyruvic acid sodium purchased from MedChemExpress. Usage Cited in: Toxicology. 2025 Oct 13:519:154309.  [Abstract]

    Renal tubular epithelial cells were treated with DMSO, 3 mM Pyruvic acid sodium, and 25 μM lovastatin (with or without 3 mM Pyruvic acid sodium) for 48 hours. ROS generation of the microarray epithelial cells was assessed by DCFH-DA staining.

    Pyruvic acid sodium purchased from MedChemExpress. Usage Cited in: Toxicology. 2025 Oct 13:519:154309.  [Abstract]

    Renal tubular epithelial cells were treated with DMSO, 3 mM Pyruvic acid sodium, and 25 μM lovastatin (with or without 3 mM Pyruvic acid sodium) for 48 hours. Damage to renal tubular epithelial cells on the chip was measured using the LDH assay.

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    Description

    Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[1][2].

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    In Vitro

    In the process of scavenging hydrogen peroxide, Sodium 2-oxopropanoate (Sodium pyruvate) is decarboxylated to lactate and hence diverted away from aerobic metabolism and further ROS generation. Under conditions in which pyruvate stimulated JNK1 activity, both mitochondrial and cytosolic ROS levels rose. An increase in JNK1 activity in a variety of different cell types over a range of pyruvate concentrations are observed[1].
    Sodium 2-oxopropanoate (Sodium pyruvate) is an effective scavenger of H2O2 as well as of O2·-, thereby protecting the lens against oxidative stress and consequent cataract formation, under in vitro as well as in vivo conditions, Sodium 2-oxopropanoate has also been shown to protect the lens proteins against glycation by competitively inhibiting the initial reaction between the sugar carbonyl and the protein -NH2[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Pyruvic acid sodium Related Antibodies
    In Vivo

    Neonatal rats are given a bolus of Sodium 2-oxopropanoate (Sodium pyruvate; 0.1-10 g/kg), and 1 h later, levels of JNK1 activity were determined in liver extracts. Sodium 2-oxopropanoate (Sodium pyruvate) addition resulted in a significant increase in JNK1 activity. Analysis of serum levels of Sodium 2-oxopropanoate in neonatal rats revealed that baseline levels of pyruvate are 0.30 mM. At the time of sacrifice, following the largest dose of Sodium 2-oxopropanoate, serum levels rose approximately sixfold to 1.84 mM[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    110.04

    Formula

    C3H3NaO3
    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    CC(C(O[Na])=O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (908.76 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 9.0876 mL 45.4380 mL 90.8760 mL
    5 mM 1.8175 mL 9.0876 mL 18.1752 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (454.38 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.86%

    SDS (393 KB)

    COA (249 KB) HNMR (105 KB) RP-HPLC (256 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 9.0876 mL 45.4380 mL 90.8760 mL 227.1901 mL
    5 mM 1.8175 mL 9.0876 mL 18.1752 mL 45.4380 mL
    10 mM 0.9088 mL 4.5438 mL 9.0876 mL 22.7190 mL
    15 mM 0.6058 mL 3.0292 mL 6.0584 mL 15.1460 mL
    20 mM 0.4544 mL 2.2719 mL 4.5438 mL 11.3595 mL
    25 mM 0.3635 mL 1.8175 mL 3.6350 mL 9.0876 mL
    30 mM 0.3029 mL 1.5146 mL 3.0292 mL 7.5730 mL
    40 mM 0.2272 mL 1.1360 mL 2.2719 mL 5.6798 mL
    50 mM 0.1818 mL 0.9088 mL 1.8175 mL 4.5438 mL
    60 mM 0.1515 mL 0.7573 mL 1.5146 mL 3.7865 mL
    80 mM 0.1136 mL 0.5680 mL 1.1360 mL 2.8399 mL
    100 mM 0.0909 mL 0.4544 mL 0.9088 mL 2.2719 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Pyruvic acid sodium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Pyruvic acid113-24-6Sodium 2-oxopropanoateAcetylformic acidReactive Oxygen Species (ROS)Endogenous MetaboliteGlycolysisGlucoseROSfreeradicalscavengerInhibitorinhibitorinhibit

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