1. Anti-infection
    Apoptosis
  2. Bacterial
    HIV
    Apoptosis
  3. Aeroplysinin 1

Aeroplysinin 1 (Synonyms: (+)-Aeroplysinin-1)

Cat. No.: HY-19827
Handling Instructions

Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells.

For research use only. We do not sell to patients.

Aeroplysinin 1 Chemical Structure

Aeroplysinin 1 Chemical Structure

CAS No. : 28656-91-9

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Description

Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells[1][2].

IC50 & Target[1]

Bacterial

 

HIV-1

14.6 μM (IC50)

Apoptosis

 

In Vitro

Aeroplysinin 1 shows anti-proliferative effect against tumor cells (HT-1080, HTC-116, HeLa, THP-1, NOMO-1 and HL-60 cells), with IC50s ranging from 2.3 to 17 μM[1].
Aeroplysinin-1 also exhibits an antiviral activity toward HIV-1 caused by inhibition of its reverse transcriptase activity[1].
Aeroplysinin 1 inhibits P. phosphoreum, C. wailesii, P. minimum and HIV with IC50s of 3.5, 5.6, 7.0 and 14.6 μM[1].
Aeroplysinin 1 inhibits human endothelial cells (EVLC-2, HMEC, RF-24, and HUVEC cells), with IC50s ranging from 2.6 to 4.7 μM[2].
(+)-Aeroplysinin-1 (0.25-0.5 μM) blocks the EGF-dependent proliferation of both MCF-7 and ZR-75-1 human breast cancer cells and inhibits the ligand-induced endocytosis of the EGF receptor in vitro[3].

Molecular Weight

338.98

Formula

C₉H₉Br₂NO₃

CAS No.

28656-91-9

SMILES

N#CC[[email protected]]1(O)C=C(Br)C(OC)=C(Br)[[email protected]@H]1O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Aeroplysinin 1(+)-Aeroplysinin-1Aeroplysinin1Aeroplysinin-1BacterialHIVApoptosisHuman immunodeficiency virussecondarymetabolitevirusangiogenicinfectionproliferationtumorInhibitorinhibitorinhibit

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Aeroplysinin 1
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