Aeroplysinin 1
Based on 1 publication(s) in Google Scholar
Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 28656-91-9
- Formula: C9H9Br2NO3
- Molecular Weight:338.98
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Aeroplysinin 1
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Biological Activity
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Bacterial |
HIV-1 14.6 μM (IC50) |
Apoptosis |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
0.54 μM
Compound: 16; Apl-1
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Antiproliferative activity against human DU-145 cells assessed as inhibition of cell proliferation measured after 2 to 4 hrs incubation by MTT assay
Antiproliferative activity against human DU-145 cells assessed as inhibition of cell proliferation measured after 2 to 4 hrs incubation by MTT assay
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[PMID: 39270448] |
| HeLa S3 | IC50 |
18.8 μM
Compound: 1, aeroplysinin-1
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Cytotoxicity against human HeLaS3 cells after 2 hrs by MTT assay
Cytotoxicity against human HeLaS3 cells after 2 hrs by MTT assay
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[PMID: 8786366] |
| HeLa S3 | IC50 |
2 μM
Compound: 1, aeroplysinin-1
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Dose enhancement factor, ratio of IC50 for human HeLaS3 cells after 4 days to IC50 for buthionine sulfoximine-pretreated human HeLaS3 cells after 4 days by MTT assay
Dose enhancement factor, ratio of IC50 for human HeLaS3 cells after 4 days to IC50 for buthionine sulfoximine-pretreated human HeLaS3 cells after 4 days by MTT assay
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[PMID: 8786366] |
| HeLa S3 | IC50 |
2.8 μM
Compound: 1, aeroplysinin-1
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Cytotoxicity against buthionine sulfoximine-pretreated human HeLaS3 cells after 4 days by MTT assay
Cytotoxicity against buthionine sulfoximine-pretreated human HeLaS3 cells after 4 days by MTT assay
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[PMID: 8786366] |
| HeLa S3 | IC50 |
27.5 μM
Compound: 1, aeroplysinin-1
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Cytotoxicity against human HeLaS3 cells after 2 weeks by clonogenic assay
Cytotoxicity against human HeLaS3 cells after 2 weeks by clonogenic assay
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[PMID: 8786366] |
| HeLa S3 | IC50 |
3.5 μM
Compound: 1, aeroplysinin-1
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Dose enhancement factor, ratio of IC50 for human HeLaS3 cells after 2 hrs to IC50 for buthionine sulfoximine-pretreated human HeLaS3 cells after 2 hrs by MTT assay
Dose enhancement factor, ratio of IC50 for human HeLaS3 cells after 2 hrs to IC50 for buthionine sulfoximine-pretreated human HeLaS3 cells after 2 hrs by MTT assay
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[PMID: 8786366] |
| HeLa S3 | IC50 |
5.4 μM
Compound: 1, aeroplysinin-1
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Cytotoxicity against buthionine sulfoximine-pretreated human HeLaS3 cells after 2 hrs by MTT assay
Cytotoxicity against buthionine sulfoximine-pretreated human HeLaS3 cells after 2 hrs by MTT assay
|
[PMID: 8786366] |
| HeLa S3 | IC50 |
5.6 μM
Compound: 1, aeroplysinin-1
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Cytotoxicity against human HeLaS3 cells after 4 days by MTT assay
Cytotoxicity against human HeLaS3 cells after 4 days by MTT assay
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[PMID: 8786366] |
| PC-3 | IC50 |
0.12 μM
Compound: 16; Apl-1
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Antiproliferative activity against human PC-3 cells assessed as inhibition of cell proliferation measured after 2 to 4 hrs incubation by MTT assay
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell proliferation measured after 2 to 4 hrs incubation by MTT assay
|
[PMID: 39270448] |
Aeroplysinin 1 shows anti-proliferative effect against tumor cells (HT-1080, HTC-116, HeLa, THP-1, NOMO-1 and HL-60 cells), with IC50s ranging from 2.3 to 17 μM[1].
Aeroplysinin-1 also exhibits an antiviral activity toward HIV-1 caused by inhibition of its reverse transcriptase activity[1].
Aeroplysinin 1 inhibits P. phosphoreum, C. wailesii, P. minimum and HIV with IC50s of 3.5, 5.6, 7.0 and 14.6 μM[1].
Aeroplysinin 1 inhibits human endothelial cells (EVLC-2, HMEC, RF-24, and HUVEC cells), with IC50s ranging from 2.6 to 4.7 μM[2].
(+)-Aeroplysinin-1 (0.25-0.5 μM) blocks the EGF-dependent proliferation of both MCF-7 and ZR-75-1 human breast cancer cells and inhibits the ligand-induced endocytosis of the EGF receptor in vitro[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 28656-91-9
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Appearance Solid
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Molecular Weight 338.98
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Formula C9H9Br2NO3
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Color White to off-white
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SMILES
N#CC[C@]1(O)C=C(Br)C(OC)=C(Br)[C@@H]1O
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Synonyms
(+)-Aeroplysinin-1
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 3.39 mg/mL (10.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. García-Vilas JA, et al. Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug. Mar Drugs. 2015;14(1):1. Published 2015 Dec 22. [Content Brief]
[2]. Martínez-Poveda B, et al. The brominated compound aeroplysinin-1 inhibits proliferation and the expression of key pro- inflammatory molecules in human endothelial and monocyte cells. PLoS One. 2013;8(1):e55203. [Content Brief]
[3]. Kreuter MH, et al. Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+)-aeroplysinin-1. Comp Biochem Physiol B. 1990;97(1):151‐158. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9500 mL | 14.7501 mL | 29.5003 mL | 73.7507 mL |
| 5 mM | 0.5900 mL | 2.9500 mL | 5.9001 mL | 14.7501 mL |
Aeroplysinin 1 Related Classifications
HY-19827 Related Classifications
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