28656-91-9
28656-91-9
Chemical Structure
Aeroplysinin 1
Synonym(s): (+)-Aeroplysinin-1
- CAS No.: 28656-91-9
- Formula:C9H9Br2NO3
- Molecular Weight:338.98
IUPAC Name: 2-((1S,6R)-3,5-dibromo-1,6-dihydroxy-4-methoxycyclohexa-2,4-dien-1-yl)acetonitrile
InChIKey: BGYNLOSBKBOJJD-IUCAKERBSA-N
SMILES: N#CC[C@]1(O)C=C(Br)C(OC)=C(Br)[C@@H]1O
Biological Activity: Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Aeroplysinin 1 | 95.0% | Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells. | ||||||||||||||||||||
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trans-Sobrerol | 99.75% | trans-Sobrerol (NRM-331) is a potent mucofluidifying agent. trans-Sobrerol demonstrates an anti-amnesic effect by enhancing hippocampal cholinergic signaling, alongside exhibiting anti-tau and anti-Aβ synthesis properties. trans-Sobrerol mitigates memory impairment induced by Scopolamine (HY-N0296). trans-Sobrerol can be used in the research of Alzheimer's disease. | ||||||||||||||||||||
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Sobrerol | Sobrerol ((Rac)-NRM-331) is a monoterpene compound. Sobrerol promotes mucus clearance and improves respiratory infections. Sobrerol can be used in research on respiratory diseases. | |||||||||||||||||||||
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Pestalotin | Pestalotin, a fungal lactone, is a secondary metabolite of endophytic fungus Pestalotiopsis microspore. | |||||||||||||||||||||
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Agistatin D | Agistatin D is a pyranacetal originally isolated from a Fusarium sp. that inhibits the cholesterol biosynthesis. | |||||||||||||||||||||
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Huazhongilexol | Huazhongilexol is a cyano compound found in ilex centrochinensis. | |||||||||||||||||||||
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Umbellatolide A | Umbellatolide A is an 11-noriridoid found in the aerial parts of Morinda umbellata. Umbellatolide A shows no significant cytotoxic activity against human cancer cells. | |||||||||||||||||||||
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p-Menth-8-ene-1,2-diol | p-Menth-8-ene-1,2-diol ((±)-1-Hydroxyisodihydrocarveol) is a Phenols product that can be isolated from the seeds of Vitis vinifera. | |||||||||||||||||||||
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Mullilam diol | Mullilam diol is a Monoterpenoids product that can be isolated from the herbs of Zanthoxylum budrunga Wall.. | |||||||||||||||||||||
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Coclauril | Coclauril is an inhibitor of HBV. Coclauril inhibits HBV replication in the human hepatoblastoma cell line with an EC50 of 7.6 μg/mL. | |||||||||||||||||||||
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p-Menth-1-ene-3,6-diol | p-Menth-1-ene-3,6-diol ((3R,4R,6S)-3,6-Dihydroxy-1-menthene) is a Flavonoids product that can be isolated from the roots of Pueraria lobata. | |||||||||||||||||||||
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References
- [1]. García-Vilas JA, et al. Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug. Mar Drugs. 2015;14(1):1. Published 2015 Dec 22. [Content Brief]
- [2]. Martínez-Poveda B, et al. The brominated compound aeroplysinin-1 inhibits proliferation and the expression of key pro- inflammatory molecules in human endothelial and monocyte cells. PLoS One. 2013;8(1):e55203. [Content Brief]
