Cat. No.: HY-N7719

Oosporein

Customer Review

Based on 1 Customer Validation

Oosporein is a microbial metabolite and a red crystalline toxin produced by various fungi. Oosporein can promote the reproduction of fungi in host bodies by inhibiting insect immunity, and possesses multiple activities such as antibacterial, antiviral (HSV), and insecticidal effects. Oosporein can inhibit plant growth. In addition, Oosporein can also induce apoptosis, cell membrane damage, oxidative stress, and mitochondrial damage. Oosporein has certain antitumor activity.

For research use only. We do not sell to patients.

Purity: 99.16%
CAS No.: 475-54-7
Formula: C₁₄H₁₀O₈
Molecular Weight:306.22

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Oosporein Chemical Structure

CAS No.: 475-54-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[4]

Microbial Metabolite

Caspase 3

Caspase-6

Caspase-9

All Endogenous Metabolite Isoforms :

All Parasite Isoforms :

All Caspase Isoforms :

All HSV Isoforms :

In Vitro

Oosporein exhibits antitumor activity in HL-60 and A549 cells, with an IC₅₀ of 28.66 μM^[1].
Oosporein shows moderate antibacterial activity against Gram-positive bacteria (such as Staphylococcus aureus, Bacillus subtilis, and Micrococcus lysodeikticus), with MIC values of 12.5-50 μg/mL^[2].
Oosporein (10 μM-10 mM; 1-14 days) can inhibit the growth of plants like oats and wheat coleoptiles, and also cause abnormal plant morphology, such as dwarfing of tobacco and kidney bean plants and leaf shrinkage^[3].
Oosporein (0-200 µM; 2-24 h) inhibits cell viability, induces apoptosis, causes cell membrane damage, oxidative stress, and mitochondrial damage in MDCK and RAW 264.7 cells, such as increasing intracellular ROS production, decreasing mitochondrial membrane potential, and enhancing glutathione hydroxylase generation^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[4]

Cell Line:

Madin-Darby canine kidney (MDCK) and RAW 264.7 cells
Concentration:

0, 5, 10, 25, 50, 100, 150 and 200 µM
Incubation Time:

3 and 24 h
Result:

Inhibited the cell viability, with IC₅₀ values of 86 µM and 78 µM for MDCK and RAW 264.7 cells for 24 h exposure, respectively.

Real Time qPCR^[4]

Cell Line:

Madin-Darby canine kidney (MDCK) and RAW 264.7 cells
Concentration:

25, 50 and 100 μM
Incubation Time:

2 h
Result:

Increased the mRNA levels of HSP70, CAS3, CAS6, and CAS9.

In Vivo

Oosporein has an oral LD₅₀ of 6.12 mg/kg in 1-day-old male chicks, and a dose of 10 mg/kg results in 100% lethality^[3].
Oosporein (20-200 μM; intraperitoneal injection; single dose) causes histopathological damage in the kidneys and spleens of Balb/c mice, with the degree of damage being proportional to the dose^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 475-54-7
Appearance Solid
Molecular Weight 306.22
Formula C₁₄H₁₀O₈
Color Brown to reddish brown
SMILES

O=C(C(C)=C1O)C(O)=C(C2=C(O)C(C(C)=C(O)C2=O)=O)C1=O
Structure Classification
- Quinones
- Benzene Quinones
Initial Source
- Microorganisms
Chaetomium
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 50 mg/mL (163.28 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.2656 mL

16.3281 mL

32.6563 mL

5 mM

0.6531 mL

3.2656 mL

6.5313 mL

10 mM

0.3266 mL

1.6328 mL

3.2656 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mao B Z, et al. Separation and determination of the bioactivity of oosporein from Chaetomium cupreum. African Journal of Biotechnology, 2010, 9(36).

[2]. Taniguchi M, et al. Antimicrobial and Respirationinhibitory Activities of Oosporein. Agricultural and biological chemistry, 1984, 48(4): 1065-1067.

[3]. Cole RJ, et al. Toxic effects of oosporein from Chaetomium trilaterale. J Agric Food Chem. 1974;22(3):517-520. [Content Brief]

[4]. Ramesha A, et al. Cytotoxic effects of oosporein isolated from endophytic fungus Cochliobolus kusanoi. Front Microbiol. 2015 Sep 1;6:870. [Content Brief]

[5]. Feng P, et al. C. Fungal biosynthesis of the bibenzoquinone oosporein to evade insect immunity. Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11365-70. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2656 mL	16.3281 mL	32.6563 mL	81.6407 mL
	5 mM	0.6531 mL	3.2656 mL	6.5313 mL	16.3281 mL
	10 mM	0.3266 mL	1.6328 mL	3.2656 mL	8.1641 mL
	15 mM	0.2177 mL	1.0885 mL	2.1771 mL	5.4427 mL
	20 mM	0.1633 mL	0.8164 mL	1.6328 mL	4.0820 mL
	25 mM	0.1306 mL	0.6531 mL	1.3063 mL	3.2656 mL
	30 mM	0.1089 mL	0.5443 mL	1.0885 mL	2.7214 mL
	40 mM	0.0816 mL	0.4082 mL	0.8164 mL	2.0410 mL
	50 mM	0.0653 mL	0.3266 mL	0.6531 mL	1.6328 mL
	60 mM	0.0544 mL	0.2721 mL	0.5443 mL	1.3607 mL
	80 mM	0.0408 mL	0.2041 mL	0.4082 mL	1.0205 mL
	100 mM	0.0327 mL	0.1633 mL	0.3266 mL	0.8164 mL

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Oosporein

Covalent Screening Library

Oxygen Sensing Compound Library

Antifungal Compound Library

Antibacterial Compound Library

Pyroptosis Compound Library

Antiparasitic Compound library

Microbial Metabolite Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Anti-Cancer Natural Product Library

Cell Death Library

Multi-Target Compound Library

Bioactive Compound Library Max

Covalent Screening Library Plus

Natural Product Library Plus

Bioactive Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Quinones Library

Natural Product Diversity Scaffold Library

Lactylation Compound Library

Fungal-Sourced Compound Library

Natural Product and Natural Product-Like Compound Library

Anti-Infection Compound Library

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Natural Product Library

Anti-Cancer Compound Library

Antiviral Compound Library

Anti-Aging Compound Library

All Endogenous Metabolite Isoforms

All Parasite Isoforms

All Caspase Isoforms

All HSV Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Oosporein Related Classifications

HY-N7719 Related Classifications