1. GPCR/G Protein
    Neuronal Signaling
  2. Cannabinoid Receptor
    GPR55
  3. Tetrahydromagnolol

Tetrahydromagnolol (Synonyms: Magnolignan)

Cat. No.: HY-116637
Handling Instructions

Tetrahydromagnolol (Magnolignan), a main metabolite of Magnolol, is a potent and selective cannabinoid CB2 receptor agonist with an EC50 of 170 nM and a Ki of 416 nM. Tetrahydromagnolol possesses 20-fold more selective for CB2 receptor than CB1 receptor. Tetrahydromagnolol is also a weak GPR55 receptor antagonist.

For research use only. We do not sell to patients.

Tetrahydromagnolol Chemical Structure

Tetrahydromagnolol Chemical Structure

CAS No. : 20601-85-8

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Description

Tetrahydromagnolol (Magnolignan), a main metabolite of Magnolol, is a potent and selective cannabinoid CB2 receptor agonist with an EC50 of 170 nM and a Ki of 416 nM. Tetrahydromagnolol possesses 20-fold more selective for CB2 receptor than CB1 receptor. Tetrahydromagnolol is also a weak GPR55 receptor antagonist[1].

IC50 & Target[1]

CB2

170 nM (EC50)

CB2

416 nM (Ki)

CB1

9010 nM (EC50)

CB1

2260 nM (Ki)

GPR55 receptor

 

Molecular Weight

270.37

Formula

C₁₈H₂₂O₂

CAS No.

20601-85-8

SMILES

OC1=CC=C(CCC)C=C1C2=CC(CCC)=CC=C2O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TetrahydromagnololMagnolignanCannabinoid ReceptorGPR55G protein-coupled receptor 55CB2metaboliteMagnololInhibitorinhibitorinhibit

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Tetrahydromagnolol
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