Antifungal activity of magnolol and honokiol

  • Arch Pharm Res. 2000 Feb;23(1):46-9. doi: 10.1007/BF02976465.
K H Bang  1 ,  Y K Kim ,  B S Min ,  M K Na ,  Y H Rhee ,  J P Lee ,  K H Bae
Affiliations
  • 1. R & D Center, Kolon Pharmaceutical Inc., Taejon, Korea.
PMID: 10728656 DOI: 10.1007/BF02976465
Abstract

Two neolignan compounds, magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl, 1) and honokiol (5,5'-diallyl-2,4'-dihydroxybiphenyl, 2), were isolated from the stem bark of Magnolia obovata and evaluated for Antifungal activity against various human pathogenic fungi. Compound 1 and 2 showed significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 microg/ml. Therefore, compound 1 and 2 could be used as lead compounds for the development of novel Antifungal agents.

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