20601-85-8
20601-85-8
Chemical Structure
Tetrahydromagnolol
Synonym(s): Magnolignan
- CAS No.: 20601-85-8
- Formula:C18H22O2
- Molecular Weight:270.37
IUPAC Name: 5,5'-dipropyl-[1,1'-biphenyl]-2,2'-diol
InChIKey: OYAQUBKYAKSHOA-UHFFFAOYSA-N
SMILES: OC1=CC=C(CCC)C=C1C2=CC(CCC)=CC=C2O
Biological Activity: Tetrahydromagnolol (Magnolignan), the main metabolite of Magnolol, is a potent and selective cannabinoidCB2 receptor agonist (EC50 =170 nM) and GPR55 antagonist. The Ki of Tetrahydromagnolol for CB2 is 416 nM, 20-fold higher than for the CB1 receptor. Magnolol shows antifungal, anti-inflammatory and analgesic effects[1][2][3][4].
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Tetrahydromagnolol | 99.89% | Tetrahydromagnolol (Magnolignan), the main metabolite of Magnolol, is a potent and selective cannabinoidCB2 receptor agonist (EC50 =170 nM) and GPR55 antagonist. The Ki of Tetrahydromagnolol for CB2 is 416 nM, 20-fold higher than for the CB1 receptor. Magnolol shows antifungal, anti-inflammatory and analgesic effects. | ||||||||||||||||||||
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References
- [1]. Alexander Fuchs, et al. The natural product magnolol as a lead structure for the development of potent cannabinoid receptor agonists. PLoS One. 2013 Oct 30;8(10):e77739. [Content Brief]
- [2]. Rempel V, et al. Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55. ACS Med Chem Lett. 2012 Nov 14;4(1):41-5. [Content Brief]
- [3]. Wang JP, et al. Anti-inflammatory and analgesic effects of magnolol. Naunyn Schmiedebergs Arch Pharmacol. 1992 Dec;346(6):707-12. [Content Brief]
- [4]. Bang KH, et al. Antifungal activity of magnolol and honokiol. Arch Pharm Res. 2000 Feb;23(1):46-9. [Content Brief]
Keywords
