2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. N-Lactoyl-phenylalanine

N-Lactoyl-phenylalanine  (Synonyms: Lac-Phe)

Cat. No.: HY-150012 Purity: 99.94%
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N-Lactoyl-phenylalanine is a blood-derived signaling metabolite that can be induced by exercise. N-Lactoyl-phenylalanine can reduce obesity and improve glucose tolerance.

For research use only. We do not sell to patients.

CAS No. : 183241-73-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in Water In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
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Based on 4 publication(s) in Google Scholar

Other Forms of N-Lactoyl-phenylalanine:

N-Lactoyl-phenylalanine Related Antibodies

Top Publications Citing Use of Products
In Vivo Efficacy Study
Histological Imaging/Staining
Flow Cytometry
IHC
WB
IF

    N-Lactoyl-phenylalanine purchased from MedChemExpress. Usage Cited in: Cell Mol Gastroenterol Hepatol. 2025 Jun 23:101558.  [Abstract]

    Intraperitoneal injection of N-Lactoyl-Phenylalanine (0.1-0.8 mg/kg/day) over 21 consecutive days demonstrated efficacy in alleviating symptoms of DSS-induced colitis in mice. Changes in mouse body weight were monitored throughout the study period (n = 5).

    N-Lactoyl-phenylalanine purchased from MedChemExpress. Usage Cited in: Cell Mol Gastroenterol Hepatol. 2025 Jun 23:101558.  [Abstract]

    Intraperitoneal injection of N-Lactoyl-Phenylalanine (0.1-0.8 mg/kg/day) over 21 consecutive days demonstrated efficacy in alleviating symptoms of DSS-induced colitis in mice. H&E staining was used to assess histopathologic changes in colon tissues (n = 5). Scale bar: 50 μm.

    N-Lactoyl-phenylalanine purchased from MedChemExpress. Usage Cited in: Cell Mol Gastroenterol Hepatol. 2025 Jun 23:101558.  [Abstract]

    Intraperitoneal injection of N-Lactoyl-Phenylalanine (0.2 mg/kg/day) over 21 consecutive days demonstrated efficacy in alleviating symptoms of DSS-induced colitis in mice. A representative diagram of flow cytometry analysis and its statistical results of the proportion of macrophages and T cells in the intestinal lamina propria of mice.

    N-Lactoyl-phenylalanine purchased from MedChemExpress. Usage Cited in: Cell Mol Gastroenterol Hepatol. 2025 Jun 23:101558.  [Abstract]

    Intraperitoneal injection of N-Lactoyl-Phenylalanine (0.2 mg/kg/day) over 21 consecutive days demonstrated efficacy in alleviating symptoms of DSS-induced colitis in mice. Analysis of the number of total macrophages and M1 macrophages in the colon of mice by mIHC. Scale bar: 100 μm. The statistical analysis results of mIHC.

    N-Lactoyl-phenylalanine purchased from MedChemExpress. Usage Cited in: Cell Mol Gastroenterol Hepatol. 2025 Jun 23:101558.  [Abstract]

    RAW264.7 cells, THP-1 cells, and murine BMDMs were stimulated with LPS for 2 hours. The treatment group was co-treated with N-Lactoyl-Phenylalanine (0.4, 0.8 μM) at the corresponding concentrations simultaneously with LPS stimulation. The expression levels of p65, p-p65, IκB-α, and p-IκB-α were determined by Western blotting analysis (n = 3).

    N-Lactoyl-phenylalanine purchased from MedChemExpress. Usage Cited in: Cell Mol Gastroenterol Hepatol. 2025 Jun 23:101558.  [Abstract]

    RAW264.7 cells were stimulated with LPS for 2 hours. The treatment group was co-treated with N-Lactoyl-Phenylalanine(0.4μM) at the corresponding concentrations simultaneously with LPS stimulation. The evaluation of NF-κB/p65 nuclear-cytoplasmic distribution through immunofluorescence assay (n = 3). Scale bar: 10 μm.

    N-Lactoyl-phenylalanine purchased from MedChemExpress. Usage Cited in: Cell Mol Gastroenterol Hepatol. 2025 Jun 23:101558.  [Abstract]

    Intraperitoneal injection of N-Lactoyl-Phenylalanine (0.1-0.8 mg/kg/day) over 21 consecutive days demonstrated efficacy in alleviating symptoms of DSS-induced colitis in mice. DAI scores were calculated and recorded (n = 5).

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    • Biological Activity

    • Purity & Documentation

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    Description

    N-Lactoyl-phenylalanine is a blood-derived signaling metabolite that can be induced by exercise. N-Lactoyl-phenylalanine can reduce obesity and improve glucose tolerance[1].

    In Vivo

    N-Lactoyl-phenylalanine (50 mg/kg, i.p.,once a day for 10 days) specifically suppresses energy intake in obese mice without affecting energy expenditure pathways, and this effect is not observed in lean mice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Diet-induced obese (DIO) mice model[1]
    Dosage: 50 mg/kg
    Administration: Intraperitoneal (i.p.), once a day for 10 days
    Result: Resulted in reduced cumulative food intake and reduced body weight compared with control mice. After 10 days, mice treated with N-Lactoyl-Phenylalanine also exhibited improved glucose homeostasis, and reduced adiposity without any changes in the weights of the other organs.
    Clinical Trial
    Molecular Weight

    237.25

    Formula

    C12H15NO4
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    C[C@H](O)C(N[C@H](C(O)=O)CC1=CC=CC=C1)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 20.83 mg/mL (87.80 mM; ultrasonic and warming and heat to 80°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.2150 mL 21.0748 mL 42.1496 mL
    5 mM 0.8430 mL 4.2150 mL 8.4299 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    Volume (start)

    V1

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    Concentration (final)

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 10 mg/mL (42.15 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    (per animal)

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    Dosing volume
    (per animal)

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.94%

    SDS (393 KB)

    COA (253 KB) HNMR (255 KB) RP-HPLC (246 KB) LCMS (86 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 4.2150 mL 21.0748 mL 42.1496 mL 105.3741 mL
    5 mM 0.8430 mL 4.2150 mL 8.4299 mL 21.0748 mL
    10 mM 0.4215 mL 2.1075 mL 4.2150 mL 10.5374 mL
    15 mM 0.2810 mL 1.4050 mL 2.8100 mL 7.0249 mL
    20 mM 0.2107 mL 1.0537 mL 2.1075 mL 5.2687 mL
    25 mM 0.1686 mL 0.8430 mL 1.6860 mL 4.2150 mL
    30 mM 0.1405 mL 0.7025 mL 1.4050 mL 3.5125 mL
    40 mM 0.1054 mL 0.5269 mL 1.0537 mL 2.6344 mL
    50 mM 0.0843 mL 0.4215 mL 0.8430 mL 2.1075 mL
    60 mM 0.0702 mL 0.3512 mL 0.7025 mL 1.7562 mL
    80 mM 0.0527 mL 0.2634 mL 0.5269 mL 1.3172 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    N-Lactoyl-phenylalanine Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    N-Lactoyl-phenylalanine183241-73-8Lac-PheEndogenous Metaboliteblood-borne signalling metaboliteobesityexercise-inducibleInhibitorinhibitorinhibit

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