N-Lactoyl-phenylalanine
Based on 4 publication(s) in Google Scholar
N-Lactoyl-phenylalanine, a N-lactoyl-amino acid, is a blood-derived signaling metabolite that can be induced by exercise. N-Lactoyl-phenylalanine can reduce obesity and improve glucose tolerance.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 183241-73-8
- Formula: C12H15NO4
- Molecular Weight:237.25
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) N-Lactoyl-phenylalanine
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In Vivo Efficacy Study
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Histological Imaging/Staining
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Flow Cytometry
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Diet-induced obese (DIO) mice model[1]
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Dosage:50 mg/kg
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Administration:Intraperitoneal (i.p.), once a day for 10 days
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Result:Resulted in reduced cumulative food intake and reduced body weight compared with control mice. After 10 days, mice treated with N-Lactoyl-Phenylalanine also exhibited improved glucose homeostasis, and reduced adiposity without any changes in the weights of the other organs.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 183241-73-8
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Appearance Solid
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Molecular Weight 237.25
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Formula C12H15NO4
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Color White to off-white
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SMILES
C[C@H](O)C(N[C@H](C(O)=O)CC1=CC=CC=C1)=O
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Synonyms
Lac-Phe
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (4)
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Journal Impact Factor
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Most Recent
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Biosens Bioelectron
Rapid indirect detection of N-lactoyl-phenylalanine using dual DNA biosensors based on solution-gated graphene field-effect transistor. [Abstract]2025 Apr 1:273:117149. PMID: 39818180 -
Cell Mol Gastroenterol Hepatol
Exercise-induced Metabolite N-lactoyl-phenylalanine Ameliorates Colitis by Inhibiting M1 Macrophage Polarization Via the Suppression of the NF-κB Signaling Pathway. [Abstract]2025;19(10):101558. PMID: 40562095
N-Lactoyl-phenylalanine purchased from MedChemExpress. Usage Cited in: Cell Mol Gastroenterol Hepatol. 2025;19(10):101558. [Abstract]
Intraperitoneal injection of N-Lactoyl-Phenylalanine (0.1-0.8 mg/kg/day) over 21 consecutive days demonstrated efficacy in alleviating symptoms of DSS-induced colitis in mice. Changes in mouse body weight were monitored throughout the study period (n = 5).
N-Lactoyl-phenylalanine purchased from MedChemExpress. Usage Cited in: Cell Mol Gastroenterol Hepatol. 2025;19(10):101558. [Abstract]
Intraperitoneal injection of N-Lactoyl-Phenylalanine (0.1-0.8 mg/kg/day) over 21 consecutive days demonstrated efficacy in alleviating symptoms of DSS-induced colitis in mice. H&E staining was used to assess histopathologic changes in colon tissues (n = 5). Scale bar: 50 μm.
N-Lactoyl-phenylalanine purchased from MedChemExpress. Usage Cited in: Cell Mol Gastroenterol Hepatol. 2025;19(10):101558. [Abstract]
Intraperitoneal injection of N-Lactoyl-Phenylalanine (0.2 mg/kg/day) over 21 consecutive days demonstrated efficacy in alleviating symptoms of DSS-induced colitis in mice. A representative diagram of flow cytometry analysis and its statistical results of the proportion of macrophages and T cells in the intestinal lamina propria of mice.
N-Lactoyl-phenylalanine purchased from MedChemExpress. Usage Cited in: Cell Mol Gastroenterol Hepatol. 2025;19(10):101558. [Abstract]
Intraperitoneal injection of N-Lactoyl-Phenylalanine (0.2 mg/kg/day) over 21 consecutive days demonstrated efficacy in alleviating symptoms of DSS-induced colitis in mice. Analysis of the number of total macrophages and M1 macrophages in the colon of mice by mIHC. Scale bar: 100 μm. The statistical analysis results of mIHC.
N-Lactoyl-phenylalanine purchased from MedChemExpress. Usage Cited in: Cell Mol Gastroenterol Hepatol. 2025;19(10):101558. [Abstract]
RAW264.7 cells, THP-1 cells, and murine BMDMs were stimulated with LPS for 2 hours. The treatment group was co-treated with N-Lactoyl-Phenylalanine (0.4, 0.8 μM) at the corresponding concentrations simultaneously with LPS stimulation. The expression levels of p65, p-p65, IκB-α, and p-IκB-α were determined by Western blotting analysis (n = 3).
N-Lactoyl-phenylalanine purchased from MedChemExpress. Usage Cited in: Cell Mol Gastroenterol Hepatol. 2025;19(10):101558. [Abstract]
RAW264.7 cells were stimulated with LPS for 2 hours. The treatment group was co-treated with N-Lactoyl-Phenylalanine(0.4μM) at the corresponding concentrations simultaneously with LPS stimulation. The evaluation of NF-κB/p65 nuclear-cytoplasmic distribution through immunofluorescence assay (n = 3). Scale bar: 10 μm.
N-Lactoyl-phenylalanine purchased from MedChemExpress. Usage Cited in: Cell Mol Gastroenterol Hepatol. 2025;19(10):101558. [Abstract]
Intraperitoneal injection of N-Lactoyl-Phenylalanine (0.1-0.8 mg/kg/day) over 21 consecutive days demonstrated efficacy in alleviating symptoms of DSS-induced colitis in mice. DAI scores were calculated and recorded (n = 5).
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Cells
N-Lactoyl Phenylalanine Disrupts Insulin Signaling, Induces Inflammation, and Impairs Mitochondrial Respiration in Cell Models. [Abstract]2025 Aug 20;14(16):1296. PMID: 40862774 -
Solvent & Solubility
H2O : 20.83 mg/mL (87.80 mM; ultrasonic and warming and heat to 80°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 10 mg/mL (42.15 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
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- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 4.2150 mL | 21.0748 mL | 42.1496 mL | 105.3741 mL |
| 5 mM | 0.8430 mL | 4.2150 mL | 8.4299 mL | 21.0748 mL | |
| 10 mM | 0.4215 mL | 2.1075 mL | 4.2150 mL | 10.5374 mL | |
| 15 mM | 0.2810 mL | 1.4050 mL | 2.8100 mL | 7.0249 mL | |
| 20 mM | 0.2107 mL | 1.0537 mL | 2.1075 mL | 5.2687 mL | |
| 25 mM | 0.1686 mL | 0.8430 mL | 1.6860 mL | 4.2150 mL | |
| 30 mM | 0.1405 mL | 0.7025 mL | 1.4050 mL | 3.5125 mL | |
| 40 mM | 0.1054 mL | 0.5269 mL | 1.0537 mL | 2.6344 mL | |
| 50 mM | 0.0843 mL | 0.4215 mL | 0.8430 mL | 2.1075 mL | |
| 60 mM | 0.0702 mL | 0.3512 mL | 0.7025 mL | 1.7562 mL | |
| 80 mM | 0.0527 mL | 0.2634 mL | 0.5269 mL | 1.3172 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
N-Lactoyl-phenylalanine Related Classifications
HY-150012 Related Classifications
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