1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. 5'-Methylthioadenosine

5'-Methylthioadenosine is produced from S-adenosylmethionine and behaves as a powful inhibitory product.

For research use only. We do not sell to patients.

5'-Methylthioadenosine Chemical Structure

5'-Methylthioadenosine Chemical Structure

CAS No. : 2457-80-9

Size Price Stock Quantity
10 mM * 1 mL USD 55 In-stock
Estimated Time of Arrival: December 31
25 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

5'-Methylthioadenosine is produced from S-adenosylmethionine and behaves as a powful inhibitory product.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

5'-Methylthioadenosine (MTA) can affect cellular processes in many ways. 5'-Methylthioadenosine has been shown to influence numerous critical responses of the cell including regulation of gene expression, proliferation, differentiation and apoptosis. Although most of these responses have been observed at the pharmacological level, their specificity makes it tempting to speculate that endogenous 5'-Methylthioadenosine could play a regulatory role in the cell. Finally, observations carried out in models of liver damage and cancer demonstrate a therapeutic potential for 5'-Methylthioadenosine that deserves further consideration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

297.33

Formula

C₁₁H₁₅N₅O₃S

CAS No.
SMILES

O[[email protected]@H]([[email protected]]([[email protected]](N1C=NC2=C1N=CN=C2N)O3)O)[[email protected]]3CSC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (168.16 mM; Need ultrasonic)

DMF : 2.5 mg/mL (8.41 mM; Need ultrasonic)

H2O : 1 mg/mL (3.36 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3633 mL 16.8163 mL 33.6327 mL
5 mM 0.6727 mL 3.3633 mL 6.7265 mL
10 mM 0.3363 mL 1.6816 mL 3.3633 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.41 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.41 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.67%

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Keywords:

5'-Methylthioadenosine5'-(Methylthio)-5'-deoxyadenosine 5'-Deoxy-5'-(methylthio)adenosine 5'-S-Methyl-5'-thioadenosineEndogenous MetaboliteInhibitorinhibitorinhibit

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Product Name:
5'-Methylthioadenosine
Cat. No.:
HY-16938
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