N-Lactoyl-phenylalanine-13C6
Based on 1 Customer Validation
N-Lactoyl-phenylalanine-13C6 (Lac-Phe-13C6) is 13C labeled N-Lactoyl-phenylalanine. N-Lactoyl-phenylalanine, a N-lactoyl-amino acid, is a blood-derived signaling metabolite that can be induced by exercise. N-Lactoyl-phenylalanine can reduce obesity and improve glucose tolerance.
For research use only. We do not sell to patients.
- Purity : 98.47%
- Formula: C613C6H15NO4
- Molecular Weight:243.21
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 183241-73-8
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Appearance Solid
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Molecular Weight 243.21
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Formula C613C6H15NO4
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Color White to off-white
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SMILES
C[C@H](O)C(N[C@H](C(O)=O)C[13C]1=[13CH][13CH]=[13CH][13CH]=[13CH]1)=O
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Synonyms
Lac-Phe-13C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
H2O : 100 mg/mL (411.17 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.1117 mL | 20.5584 mL | 41.1167 mL | 102.7918 mL |
| 5 mM | 0.8223 mL | 4.1117 mL | 8.2233 mL | 20.5584 mL | |
| 10 mM | 0.4112 mL | 2.0558 mL | 4.1117 mL | 10.2792 mL | |
| 15 mM | 0.2741 mL | 1.3706 mL | 2.7411 mL | 6.8528 mL | |
| 20 mM | 0.2056 mL | 1.0279 mL | 2.0558 mL | 5.1396 mL | |
| 25 mM | 0.1645 mL | 0.8223 mL | 1.6447 mL | 4.1117 mL | |
| 30 mM | 0.1371 mL | 0.6853 mL | 1.3706 mL | 3.4264 mL | |
| 40 mM | 0.1028 mL | 0.5140 mL | 1.0279 mL | 2.5698 mL | |
| 50 mM | 0.0822 mL | 0.4112 mL | 0.8223 mL | 2.0558 mL | |
| 60 mM | 0.0685 mL | 0.3426 mL | 0.6853 mL | 1.7132 mL | |
| 80 mM | 0.0514 mL | 0.2570 mL | 0.5140 mL | 1.2849 mL | |
| 100 mM | 0.0411 mL | 0.2056 mL | 0.4112 mL | 1.0279 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
N-Lactoyl-phenylalanine-13C6 Related Classifications
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