4-Hydroxytolbutamide
Based on 1 Customer Validation
4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic.
For research use only. We do not sell to patients.
- Purity: 99.69%
- CAS No.: 5719-85-7
- Formula: C12H18N2O4S
- Molecular Weight:286.35
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Potassium channel
Chemical Information
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CAS No. 5719-85-7
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Appearance Solid
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Molecular Weight 286.35
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Formula C12H18N2O4S
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Color White to off-white
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SMILES
O=S(C1=CC=C(CO)C=C1)(NC(NCCCC)=O)=O
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Synonyms
Hydroxytolbutamide
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (436.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (545 KB)
- English - EN (545 KB)
- Français - FR (545 KB)
- Deutsch - DE (545 KB)
- Norwegian - NO (545 KB)
- Español - ES (545 KB)
- Swedish - SV (545 KB)
- Italian - IT (545 KB)
- Portuguese - PT (545 KB)
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Handling Instructions (2659 KB)
References
[1]. Hansen LL, et al. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Ther Drug Monit. 1999 Dec;21(6):664-71. [Content Brief]
[2]. Yuan R, et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab Dispos. 2002 Dec;30(12):1311-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4922 mL | 17.4611 mL | 34.9223 mL | 87.3057 mL |
| 5 mM | 0.6984 mL | 3.4922 mL | 6.9845 mL | 17.4611 mL | |
| 10 mM | 0.3492 mL | 1.7461 mL | 3.4922 mL | 8.7306 mL | |
| 15 mM | 0.2328 mL | 1.1641 mL | 2.3282 mL | 5.8204 mL | |
| 20 mM | 0.1746 mL | 0.8731 mL | 1.7461 mL | 4.3653 mL | |
| 25 mM | 0.1397 mL | 0.6984 mL | 1.3969 mL | 3.4922 mL | |
| 30 mM | 0.1164 mL | 0.5820 mL | 1.1641 mL | 2.9102 mL | |
| 40 mM | 0.0873 mL | 0.4365 mL | 0.8731 mL | 2.1826 mL | |
| 50 mM | 0.0698 mL | 0.3492 mL | 0.6984 mL | 1.7461 mL | |
| 60 mM | 0.0582 mL | 0.2910 mL | 0.5820 mL | 1.4551 mL | |
| 80 mM | 0.0437 mL | 0.2183 mL | 0.4365 mL | 1.0913 mL | |
| 100 mM | 0.0349 mL | 0.1746 mL | 0.3492 mL | 0.8731 mL |
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