5719-85-7
5719-85-7
Chemical Structure
4-Hydroxytolbutamide
Synonym(s): Hydroxytolbutamide
- CAS No.: 5719-85-7
- Formula:C12H18N2O4S
- Molecular Weight:286.35
IUPAC Name: N-(butylcarbamoyl)-4-(hydroxymethyl)benzenesulfonamide
InChIKey: SJRHYONYKZIRPM-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(CO)C=C1)(NC(NCCCC)=O)=O
Biological Activity: 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].
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4-Hydroxytolbutamide | 99.69% | 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic. | ||||||||||||||||||||
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4-Hydroxytolbutamide-d9 | 99.29% | 4-Hydroxytolbutamide-d9 is the deuterium labeled 4-Hydroxytolbutamide. 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic. | ||||||||||||||||||||
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4-Hydroxytolbutamide-d9-1 | 4-Hydroxytolbutamide-d9-1 (Hydroxytolbutamide-d9-1) is the deuterium labeled 4-Hydroxytolbutamide (HY-100641). 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic. | |||||||||||||||||||||
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References
- [1]. Hansen LL, et al. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Ther Drug Monit. 1999 Dec;21(6):664-71. [Content Brief]
- [2]. Yuan R, et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab Dispos. 2002 Dec;30(12):1311-9. [Content Brief]
