Mannose 1-phosphate
Mannose 1-phosphate is a phosphorylated mannose that serves as a precursor of GDP-mannose, a constituent unit of glycosylation biosynthetic pathways. Mannose 1-phosphate increases intracellular GDP-mannose concentration, promotes normalization of lipid-linked oligosaccharide structures, and enhances the formation of mature N-glycans on cellular proteins. Mannose 1-phosphate can be used in studies related to glycosylation disorders.
For research use only. We do not sell to patients.
- CAS No.: 27251-84-9
- Formula: C6H13O9P
- Molecular Weight:260.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Mannose 1-phosphate (1 mM; 24 h) significantly improves global N-glycosylation by increasing mature Man6+ high mannose and complex/hybrid glycopeptides, and reduces immature smaller glycans, in PMM2-CDG, ALG2-CDG, and ALG11-CDG skin fibroblasts, with the most dramatic effects observed in PMM2-CDG and ALG2-CDG cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 27251-84-9
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Molecular Weight 260.14
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Formula C6H13O9P
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SMILES
O[C@@H]1C(OP(O)(O)=O)O[C@H](CO)[C@@H](O)[C@@H]1O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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