Mannose 1-phosphate 

Mannose 1-phosphate is a phosphorylated mannose that serves as a precursor of GDP-mannose, a constituent unit of glycosylation biosynthetic pathways. Mannose 1-phosphate increases intracellular GDP-mannose concentration, promotes normalization of lipid-linked oligosaccharide structures, and enhances the formation of mature N-glycans on cellular proteins. Mannose 1-phosphate can be used in studies related to glycosylation disorders^[1].

Mannose 1-phosphate (1 mM; 24 h) significantly improves global N-glycosylation by increasing mature Man⁶⁺ high mannose and complex/hybrid glycopeptides, and reduces immature smaller glycans, in PMM2-CDG, ALG2-CDG, and ALG11-CDG skin fibroblasts, with the most dramatic effects observed in PMM2-CDG and ALG2-CDG cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

260.14

C₆H₁₃O₉P

27251-84-9

O[C@@H]1C(OP(O)(O)=O)O[C@H](CO)[C@@H](O)[C@@H]1O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Budhraja R, et al. Liposome-encapsulated mannose-1-phosphate therapy improves global N-glycosylation in different congenital disorders of glycosylation. Mol Genet Metab. 2024;142(2):108487.  [Content Brief]