1. GPCR/G Protein
  2. Guanylate Cyclase
  3. MM 419447

MM 419447 

Cat. No.: HY-P3282
Handling Instructions

MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

MM 419447 Chemical Structure

MM 419447 Chemical Structure

CAS No. : 1092457-78-7

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Description

MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C)[1].

In Vitro

MM 419447 exhibits high-affinity binding to T84 cells, resulting in a significant, concentration-dependent accumulation of intracellular cyclic guanosine-39,59-monophosphate (cGMP)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MM 419447 (10 mg/kg; p.o.) treatment shows the Cmax, AUC0-6 and t1/2 values of 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague-Dawley rats[1]
Dosage: 10 mg/kg
Administration: P.o. (Pharmacokinetic Analysis)
Result: The Cmax, AUC0-6 and Tmax were 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively.
Molecular Weight

1363.56

Formula

C₅₀H₇₀N₁₄O₁₉S₆

CAS No.
Sequence Shortening

CCEYCCNPACTGC (Disulfide bridge:Cys1-Cys6; Cys2-Cys10; Cys5-Cys13)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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MM 419447
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HY-P3282
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