Phosphorylcholine chloride calcium salt tetrahydrate

Name: Phosphorylcholine chloride calcium salt tetrahydrate
Brand: MedChemExpress
SKU: HY-W011249
Rating: 5.0 (12 reviews)

Cat. No.: HY-W011249 Assay: 100.80%: Data Sheet
COA

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Phosphorylcholine chloride calcium salt tetrahydrate is an endogenous metabolite.

For research use only. We do not sell to patients.

CAS No. : 72556-74-2

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
500 g	In-stock	Estimated Time of Arrival: December 31
> 100 g	Get quote

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Customer Review

Based on 12 publication(s) in Google Scholar

Other Forms of Phosphorylcholine chloride calcium salt tetrahydrate:

Phosphorylcholine chloride In-stock
Calcium phosphorylcholine chloride, 98% In-stock
Phosphorylcholine In-stock
Phosphorylcholine chloride calcium salt tetrahydrate (Standard) Get quote

12 Publications Citing Use of MCE Phosphorylcholine chloride calcium salt tetrahydrate

In Vivo Efficacy Study

ELISA

Histological Imaging/Staining

Bio/Physico-chemical Assay

Flow Cytometry

: Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Nov 11;58(11):2670-2684.e10. [Abstract]; Phosphorylcholine (PC, 10 μM; 24 h) increased HSV-1-induced cGAS-STING signaling and reduced HSV-1 replication in L929 cells.

: Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Nov 11;58(11):2670-2684.e10. [Abstract]; SMPDL3B (5 μM) were pre-incubated with Phosphorylcholine (PC, 100 μM) or ENPP1-1-IN-14 (100 μM) at 4°C for 30 min, and then incubated with cGAMP (100 μM) at 37°C for 3 h. The concentration of cGAMP was examined by cGAMP ELISA kit.

: Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Nov 11;58(11):2670-2684.e10. [Abstract]; SMPDL3B was pre-incubated with or without Phosphorylcholine (PC, 10 μM) at 4°C for 1 h, and then incubated with or without cGAMP (100 μM) at 37°C for 4 h. RAW-Lucia ISG cells were stimulated with the above reaction products (50-fold dilution) for 24 h and the ISRE reporter activity was assessed following the standard protocol.

: Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]; The pig intestines of the Phosphorylcholine (PC) (10 mg/kg; once daily for 8 days) pretreatment group exhibited mild congestion and edema in gut appearance, while the PEDV group showed obvious lesions and severe congestion and edema.

: Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]; Phosphorylcholine (PC) (10 mg/kg; once daily for 8 d) mitigated the negative impacts of intestinal virus, as evidenced by improved survival rates and body weight changes, and alleviated broken villi and extensive epithelial cell shedding in piglets.

: Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]; Phosphorylcholine (PC) (1, 5, and 10 μM; 24 h) treatment at different concentrations inhibited PEDV-induced cell death in both IPEC-J2 and Vero cells.

: Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]; Expression analysis of RIPK1, p-RIPK1, RIPK3, p-RIPK3, MLKL, p-MLKL, and PEDV-N in IPEC-J2 cells pre-treated with various Phosphorylcholine (PC) (1, 5, and 10 μM) concentrations post-PEDV infection. Phosphorylcholine (PC) (1, 5, and 10 μM) treatment reduced the phosphorylation levels of RIPK1, RIPK3, and MLKL.

: Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]; Phosphorylcholine (PC) (10 mg/kg; once daily for 8 days) pretreatment alleviated viral infection of the pig's intestines, keeping the intestinal villi and tissue structure intact, with only minor damage and epithelial cell shedding.

: Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2023 Sep 4;9(1):62. [Abstract]; Fecal water content and fecal Na⁺ content; C57BL/6 male mice were either orally administrated with 0.1 mL PBS (CONT group) or 0.1 mL Phosphorylcholine at a concentration of 2.5 mol/L (PC group) for 7 days. The results showed that that Phosphorylcholine increased fecal water and Na⁺ content.

: Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2023 Sep 4;9(1):62. [Abstract]; Colonic morphology (Scale bar = 200 μm; arrows, impaired villus). The results showed that Phosphorylcholine (Phosphocholine, 2.5 mol/L; 0.1 mL; i.g.; once daily for 7 days) protected mice from morphological damage.

: Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2023 Sep 4;9(1):62. [Abstract]; Phosphorylcholine (Phosphocholine, 2.5 mol/L; 0.1 mL; i.g.; once daily for 7 days) alleviated C. rodentium-induced apoptosis, as indicated by decreased caspase-3 expression (Fig. n), and epithelial proliferation, as indicated by decreased Ki67 expression (Fig. o).

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Description

Phosphorylcholine chloride calcium salt tetrahydrate is an endogenous metabolite.

IC₅₀ & Target

Human Endogenous Metabolite

Microbial Metabolite

Molecular Weight

329.73

Formula

C₅H₂₁CaClNO₈P

CAS No.

72556-74-2

Appearance

Solid

Color

White to off-white

SMILES

C[N+](C)(CCOP([O-])([O-])=O)C.[Ca+2].[Cl-].O.O.O.O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (303.28 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0328 mL	15.1639 mL	30.3278 mL
5 mM	0.6066 mL	3.0328 mL	6.0656 mL
10 mM	0.3033 mL	1.5164 mL	3.0328 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 100.80%

Select Batch:

Data Sheet (249 KB) SDS (394 KB)

COA (251 KB) HNMR (141 KB) CNMR (123 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.0328 mL	15.1639 mL	30.3278 mL	75.8196 mL
	5 mM	0.6066 mL	3.0328 mL	6.0656 mL	15.1639 mL
	10 mM	0.3033 mL	1.5164 mL	3.0328 mL	7.5820 mL
	15 mM	0.2022 mL	1.0109 mL	2.0219 mL	5.0546 mL
	20 mM	0.1516 mL	0.7582 mL	1.5164 mL	3.7910 mL
	25 mM	0.1213 mL	0.6066 mL	1.2131 mL	3.0328 mL
	30 mM	0.1011 mL	0.5055 mL	1.0109 mL	2.5273 mL
	40 mM	0.0758 mL	0.3791 mL	0.7582 mL	1.8955 mL
	50 mM	0.0607 mL	0.3033 mL	0.6066 mL	1.5164 mL
	60 mM	0.0505 mL	0.2527 mL	0.5055 mL	1.2637 mL
	80 mM	0.0379 mL	0.1895 mL	0.3791 mL	0.9477 mL
	100 mM	0.0303 mL	0.1516 mL	0.3033 mL	0.7582 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.