Phosphorylcholine chloride calcium salt tetrahydrate
Based on 13 publication(s) in Google Scholar
Phosphorylcholine chloride calcium salt tetrahydrate is an endogenous metabolite.
For research use only. We do not sell to patients.
- Assay : 100.80%
- CAS No.: 72556-74-2
- Formula: C5H21CaClNO8P
- Molecular Weight:329.73
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
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HY-W011249R
Phosphorylcholine chloride calcium salt tetrahydrate (Standard) -
HY-W011500
TCEP hydrochloride -
HY-76446
Ethyl (triphenylphosphoranylidene) acetate -
HY-W099547
Dihexadecyl hydrogen phosphate -
HY-W440981
SPPC -
HY-Y1054
Magnesium stearate -
HY-21170B
Trifluoromethanesulfonate lithium -
HY-149303
Potassium tert-butoxide -
HY-Y1054R
Magnesium stearate (Standard) -
HY-W087892
Barium diphenylamine-4-sulfonate -
HY-W087892R
Barium diphenylamine-4-sulfonate (Standard)
Publications Citing Use of MedChemExpress (MCE) Phosphorylcholine chloride calcium salt tetrahydrate
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Cell Metab. 2026 Feb 3;38(2):316-330.e8. [Abstract]
- Immunity. 2025 Nov 11;58(11):2670-2684.e10. [Abstract]
- Nat Commun. 2023 Mar 24;14(1):1631. [Abstract]
- Microbiome. 2025 Apr 2;13(1):90. [Abstract]
- Adv Sci (Weinh). 2025 Jan;12(4):e2411276. [Abstract]
- NPJ Biofilms Microbiomes. 2023 Sep 4;9(1):62. [Abstract]
- Anal Chem. 2025 May 13;97(18):9827-9835. [Abstract]
- Virulence. 2025 Dec;16(1):2490208. [Abstract]
- JCI Insight. 2021 Oct 22;6(20):e151911. [Abstract]
- J Physiol Biochem. 2022 May;78(2):355-363. [Abstract]
- bioRxiv. 2026 Jun 28.
- Patent. US20250160318A1.
Customer Validation & Images
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WB
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ELISA
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Bio/Physico-chemical Assay
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In Vivo Efficacy Study
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In Vivo Efficacy Study
All Endogenous Metabolite Isoforms
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Biological Activity
Description
IC50 & Target
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Human Endogenous Metabolite |
Microbial Metabolite |
Chemical Information
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CAS No. 72556-74-2
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Appearance Solid
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Molecular Weight 329.73
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Formula C5H21CaClNO8P
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Color White to off-white
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SMILES
C[N+](C)(CCOP([O-])([O-])=O)C.[Ca+2].[Cl-].O.O.O.O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (13)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cell Metab
Endometrial stromal cell-derived TMAO sustains decidualization to prevent recurrent spontaneous abortion. [Abstract]2026 Feb 3;38(2):316-330.e8. PMID: 41512878 -
Immunity
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation. [Abstract]2025 Nov 11;58(11):2670-2684.e10. PMID: 41175872
Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Nov 11;58(11):2670-2684.e10. [Abstract]
Phosphorylcholine (PC, 10 μM; 24 h) increased HSV-1-induced cGAS-STING signaling and reduced HSV-1 replication in L929 cells.
Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Nov 11;58(11):2670-2684.e10. [Abstract]
SMPDL3B (5 μM) were pre-incubated with Phosphorylcholine (PC, 100 μM) or ENPP1-1-IN-14 (100 μM) at 4°C for 30 min, and then incubated with cGAMP (100 μM) at 37°C for 3 h. The concentration of cGAMP was examined by cGAMP ELISA kit.
Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Nov 11;58(11):2670-2684.e10. [Abstract]
SMPDL3B was pre-incubated with or without Phosphorylcholine (PC, 10 μM) at 4°C for 1 h, and then incubated with or without cGAMP (100 μM) at 37°C for 4 h. RAW-Lucia ISG cells were stimulated with the above reaction products (50-fold dilution) for 24 h and the ISRE reporter activity was assessed following the standard protocol.
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Nat Commun
Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer's disease. [Abstract]2023 Mar 24;14(1):1631. PMID: 36959217 -
Microbiome
Faecalibacterium prausnitzii-derived outer membrane vesicles reprogram gut microbiota metabolism to alleviate Porcine Epidemic Diarrhea Virus infection. [Abstract]2025 Apr 2;13(1):90. PMID: 40176190
Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]
The pig intestines of the Phosphorylcholine (PC) (10 mg/kg; once daily for 8 days) pretreatment group exhibited mild congestion and edema in gut appearance, while the PEDV group showed obvious lesions and severe congestion and edema.
Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]
Phosphorylcholine (PC) (10 mg/kg; once daily for 8 d) mitigated the negative impacts of intestinal virus, as evidenced by improved survival rates and body weight changes, and alleviated broken villi and extensive epithelial cell shedding in piglets.
Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]
Phosphorylcholine (PC) (1, 5, and 10 μM; 24 h) treatment at different concentrations inhibited PEDV-induced cell death in both IPEC-J2 and Vero cells.
Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]
Expression analysis of RIPK1, p-RIPK1, RIPK3, p-RIPK3, MLKL, p-MLKL, and PEDV-N in IPEC-J2 cells pre-treated with various Phosphorylcholine (PC) (1, 5, and 10 μM) concentrations post-PEDV infection. Phosphorylcholine (PC) (1, 5, and 10 μM) treatment reduced the phosphorylation levels of RIPK1, RIPK3, and MLKL.
Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]
Phosphorylcholine (PC) (10 mg/kg; once daily for 8 days) pretreatment alleviated viral infection of the pig's intestines, keeping the intestinal villi and tissue structure intact, with only minor damage and epithelial cell shedding.
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Adv Sci (Weinh)
Single-Cell Simultaneous Metabolome and Transcriptome Profiling Revealing Metabolite-Gene Correlation Network. [Abstract]2025 Jan;12(4):e2411276. PMID: 39629980 -
NPJ Biofilms Microbiomes
Colonic phosphocholine is correlated with Candida tropicalis and promotes diarrhea and pathogen clearance. [Abstract]2023 Sep 4;9(1):62. PMID: 37666845
Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2023 Sep 4;9(1):62. [Abstract]
Fecal water content and fecal Na+ content; C57BL/6 male mice were either orally administrated with 0.1 mL PBS (CONT group) or 0.1 mL Phosphorylcholine at a concentration of 2.5 mol/L (PC group) for 7 days. The results showed that that Phosphorylcholine increased fecal water and Na+ content.
Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2023 Sep 4;9(1):62. [Abstract]
Colonic morphology (Scale bar = 200 μm; arrows, impaired villus). The results showed that Phosphorylcholine (Phosphocholine, 2.5 mol/L; 0.1 mL; i.g.; once daily for 7 days) protected mice from morphological damage.
Phosphorylcholine chloride calcium salt tetrahydrate purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2023 Sep 4;9(1):62. [Abstract]
Phosphorylcholine (Phosphocholine, 2.5 mol/L; 0.1 mL; i.g.; once daily for 7 days) alleviated C. rodentium-induced apoptosis, as indicated by decreased caspase-3 expression (Fig. n), and epithelial proliferation, as indicated by decreased Ki67 expression (Fig. o).
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Anal Chem
Ultrahigh Flow Regulated Discharge Coupling with Targeted Mass Spectrometry Analysis: Real Time Capturing Biomolecules in Exhaled Breath. [Abstract]2025 May 13;97(18):9827-9835. PMID: 40302637 -
Virulence
2025 Dec;16(1):2490208. PMID: 40202859 -
JCI Insight
Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris. [Abstract]2021 Oct 22;6(20):e151911. PMID: 34491907 -
J Physiol Biochem
D609 inhibition of phosphatidylcholine-specific phospholipase C attenuates prolonged insulin stimulation-mediated GLUT4 downregulation in 3T3-L1 adipocytes. [Abstract]2022 May;78(2):355-363. PMID: 35048323 -
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Solvent & Solubility
In Vitro:
H2O : ≥ 100 mg/mL (303.28 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (249 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.0328 mL | 15.1639 mL | 30.3278 mL | 75.8196 mL |
| 5 mM | 0.6066 mL | 3.0328 mL | 6.0656 mL | 15.1639 mL | |
| 10 mM | 0.3033 mL | 1.5164 mL | 3.0328 mL | 7.5820 mL | |
| 15 mM | 0.2022 mL | 1.0109 mL | 2.0219 mL | 5.0546 mL | |
| 20 mM | 0.1516 mL | 0.7582 mL | 1.5164 mL | 3.7910 mL | |
| 25 mM | 0.1213 mL | 0.6066 mL | 1.2131 mL | 3.0328 mL | |
| 30 mM | 0.1011 mL | 0.5055 mL | 1.0109 mL | 2.5273 mL | |
| 40 mM | 0.0758 mL | 0.3791 mL | 0.7582 mL | 1.8955 mL | |
| 50 mM | 0.0607 mL | 0.3033 mL | 0.6066 mL | 1.5164 mL | |
| 60 mM | 0.0505 mL | 0.2527 mL | 0.5055 mL | 1.2637 mL | |
| 80 mM | 0.0379 mL | 0.1895 mL | 0.3791 mL | 0.9477 mL | |
| 100 mM | 0.0303 mL | 0.1516 mL | 0.3033 mL | 0.7582 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Phosphorylcholine chloride calcium salt tetrahydrate Related Classifications
HY-W011249 Related Classifications
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