Calcium phosphorylcholine chloride, 98%
Based on 12 publication(s) in Google Scholar
Calcium phosphorylcholine chloride, 98% is the main phospholipid component in eukaryotic biofilms. Calcium phosphorylcholine chloride, 98% exists in commensal or pathogenic bacteria associated with eukaryotes in prokaryotes. Calcium phosphorylcholine chloride, 98% exhibits a surprising range of immunomodulatory properties.
For research use only. We do not sell to patients.
- Purity: 98.95%
- CAS No.: 4826-71-5
- Formula: C5H13CaClNO4P
- Molecular Weight:257.67
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Publications Citing Use of MedChemExpress (MCE) Calcium phosphorylcholine chloride, 98%
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Cell Metab. 2026 Feb 3;38(2):316-330.e8. [Abstract]
- Immunity. 2025 Nov 11;58(11):2670-2684.e10. [Abstract]
- Nat Commun. 2023 Mar 24;14(1):1631. [Abstract]
- Microbiome. 2025 Apr 2;13(1):90. [Abstract]
- Adv Sci (Weinh). 2025 Jan;12(4):e2411276. [Abstract]
- NPJ Biofilms Microbiomes. 2023 Sep 4;9(1):62. [Abstract]
- Anal Chem. 2025 May 13;97(18):9827-9835. [Abstract]
- Virulence. 2025 Dec;16(1):2490208. [Abstract]
- JCI Insight. 2021 Oct 22;6(20):e151911. [Abstract]
- J Physiol Biochem. 2022 May;78(2):355-363. [Abstract]
- Patent. US20250160318A1.
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In Vivo Efficacy Study
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Biological Activity
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Human Endogenous Metabolite |
Microbial Metabolite |
Calcium phosphorylcholine chloride, 98% is a component of drug delivery micelles, which improves the efficiency of cellular internalization and increases the cytotoxicity of cytotoxins carried in micelles in HeLa cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Calcium phosphorylcholine chloride, 98% (2 μg; ip; once every two weeks for 4 months) induces the production of anti-PC and anti-oxLDL antibodies, increases mature B cells in the spleen, and reduces atherosclerotic lesions in the aortic root in mouse models[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4826-71-5
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Appearance Solid
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Molecular Weight 257.67
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Formula C5H13CaClNO4P
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Color White to off-white
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SMILES
O=P(OCC[N+](C)(C)C)([O-])[O-].[Ca+2].[Cl-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Publications (12)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cell Metab
Endometrial stromal cell-derived TMAO sustains decidualization to prevent recurrent spontaneous abortion. [Abstract]2026 Feb 3;38(2):316-330.e8. PMID: 41512878 -
Immunity
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation. [Abstract]2025 Nov 11;58(11):2670-2684.e10. PMID: 41175872
Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Nov 11;58(11):2670-2684.e10. [Abstract]
Phosphorylcholine (PC, 10 μM; 24 h) increased HSV-1-induced cGAS-STING signaling and reduced HSV-1 replication in L929 cells.
Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Nov 11;58(11):2670-2684.e10. [Abstract]
SMPDL3B (5 μM) were pre-incubated with Phosphorylcholine (PC, 100 μM) or ENPP1-1-IN-14 (100 μM) at 4°C for 30 min, and then incubated with cGAMP (100 μM) at 37°C for 3 h. The concentration of cGAMP was examined by cGAMP ELISA kit.
Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Nov 11;58(11):2670-2684.e10. [Abstract]
SMPDL3B was pre-incubated with or without Phosphorylcholine (PC, 10 μM) at 4°C for 1 h, and then incubated with or without cGAMP (100 μM) at 37°C for 4 h. RAW-Lucia ISG cells were stimulated with the above reaction products (50-fold dilution) for 24 h and the ISRE reporter activity was assessed following the standard protocol.
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Nat Commun
Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer's disease. [Abstract]2023 Mar 24;14(1):1631. PMID: 36959217 -
Microbiome
Faecalibacterium prausnitzii-derived outer membrane vesicles reprogram gut microbiota metabolism to alleviate Porcine Epidemic Diarrhea Virus infection. [Abstract]2025 Apr 2;13(1):90. PMID: 40176190
Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]
The pig intestines of the Phosphorylcholine (PC) (10 mg/kg; once daily for 8 days) pretreatment group exhibited mild congestion and edema in gut appearance, while the PEDV group showed obvious lesions and severe congestion and edema.
Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]
Phosphorylcholine (PC) (10 mg/kg; once daily for 8 d) mitigated the negative impacts of intestinal virus, as evidenced by improved survival rates and body weight changes, and alleviated broken villi and extensive epithelial cell shedding in piglets.
Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]
Phosphorylcholine (PC) (1, 5, and 10 μM; 24 h) treatment at different concentrations inhibited PEDV-induced cell death in both IPEC-J2 and Vero cells.
Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]
Expression analysis of RIPK1, p-RIPK1, RIPK3, p-RIPK3, MLKL, p-MLKL, and PEDV-N in IPEC-J2 cells pre-treated with various Phosphorylcholine (PC) (1, 5, and 10 μM) concentrations post-PEDV infection. Phosphorylcholine (PC) (1, 5, and 10 μM) treatment reduced the phosphorylation levels of RIPK1, RIPK3, and MLKL.
Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]
Phosphorylcholine (PC) (10 mg/kg; once daily for 8 days) pretreatment alleviated viral infection of the pig's intestines, keeping the intestinal villi and tissue structure intact, with only minor damage and epithelial cell shedding.
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Adv Sci (Weinh)
Single-Cell Simultaneous Metabolome and Transcriptome Profiling Revealing Metabolite-Gene Correlation Network. [Abstract]2025 Jan;12(4):e2411276. PMID: 39629980 -
NPJ Biofilms Microbiomes
Colonic phosphocholine is correlated with Candida tropicalis and promotes diarrhea and pathogen clearance. [Abstract]2023 Sep 4;9(1):62. PMID: 37666845
Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2023 Sep 4;9(1):62. [Abstract]
Fecal water content and fecal Na+ content; C57BL/6 male mice were either orally administrated with 0.1 mL PBS (CONT group) or 0.1 mL Phosphorylcholine at a concentration of 2.5 mol/L (PC group) for 7 days. The results showed that that Phosphorylcholine increased fecal water and Na+ content.
Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2023 Sep 4;9(1):62. [Abstract]
Colonic morphology (Scale bar = 200 μm; arrows, impaired villus). The results showed that Phosphorylcholine (Phosphocholine, 2.5 mol/L; 0.1 mL; i.g.; once daily for 7 days) protected mice from morphological damage.
Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2023 Sep 4;9(1):62. [Abstract]
Phosphorylcholine (Phosphocholine, 2.5 mol/L; 0.1 mL; i.g.; once daily for 7 days) alleviated C. rodentium-induced apoptosis, as indicated by decreased caspase-3 expression (Fig. n), and epithelial proliferation, as indicated by decreased Ki67 expression (Fig. o).
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Anal Chem
Ultrahigh Flow Regulated Discharge Coupling with Targeted Mass Spectrometry Analysis: Real Time Capturing Biomolecules in Exhaled Breath. [Abstract]2025 May 13;97(18):9827-9835. PMID: 40302637 -
Virulence
2025 Dec;16(1):2490208. PMID: 40202859 -
JCI Insight
Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris. [Abstract]2021 Oct 22;6(20):e151911. PMID: 34491907 -
J Physiol Biochem
D609 inhibition of phosphatidylcholine-specific phospholipase C attenuates prolonged insulin stimulation-mediated GLUT4 downregulation in 3T3-L1 adipocytes. [Abstract]2022 May;78(2):355-363. PMID: 35048323 -
Solvent & Solubility
H2O : 87.5 mg/mL (339.58 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (247 KB)
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SDS (419 KB)
- English - EN (419 KB)
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- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.8809 mL | 19.4047 mL | 38.8093 mL | 97.0233 mL |
| 5 mM | 0.7762 mL | 3.8809 mL | 7.7619 mL | 19.4047 mL | |
| 10 mM | 0.3881 mL | 1.9405 mL | 3.8809 mL | 9.7023 mL | |
| 15 mM | 0.2587 mL | 1.2936 mL | 2.5873 mL | 6.4682 mL | |
| 20 mM | 0.1940 mL | 0.9702 mL | 1.9405 mL | 4.8512 mL | |
| 25 mM | 0.1552 mL | 0.7762 mL | 1.5524 mL | 3.8809 mL | |
| 30 mM | 0.1294 mL | 0.6468 mL | 1.2936 mL | 3.2341 mL | |
| 40 mM | 0.0970 mL | 0.4851 mL | 0.9702 mL | 2.4256 mL | |
| 50 mM | 0.0776 mL | 0.3881 mL | 0.7762 mL | 1.9405 mL | |
| 60 mM | 0.0647 mL | 0.3234 mL | 0.6468 mL | 1.6171 mL | |
| 80 mM | 0.0485 mL | 0.2426 mL | 0.4851 mL | 1.2128 mL | |
| 100 mM | 0.0388 mL | 0.1940 mL | 0.3881 mL | 0.9702 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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