Calcium phosphorylcholine chloride, 98%

Name: Calcium phosphorylcholine chloride, 98%
Brand: MedChemExpress
SKU: HY-B2233A
Rating: 5.0 (12 reviews)

Cat. No.: HY-B2233A Assay: 98.95%: Data Sheet
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Calcium phosphorylcholine chloride, 98% is the main phospholipid component in eukaryotic biofilms. Calcium phosphorylcholine chloride, 98% exists in commensal or pathogenic bacteria associated with eukaryotes in prokaryotes. Calcium phosphorylcholine chloride, 98% exhibits a surprising range of immunomodulatory properties.

For research use only. We do not sell to patients.

CAS No. : 4826-71-5

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
500 g	In-stock	Estimated Time of Arrival: December 31
1 kg	In-stock	Estimated Time of Arrival: December 31

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Based on 12 publication(s) in Google Scholar

Other Forms of Calcium phosphorylcholine chloride, 98%:

Calcium phosphorylcholine-d₉ chloride In-stock
Phosphorylcholine chloride In-stock
Phosphorylcholine In-stock
Phosphorylcholine chloride calcium salt tetrahydrate In-stock

12 Publications Citing Use of MCE Calcium phosphorylcholine chloride, 98%

In Vivo Efficacy Study

ELISA

Histological Imaging/Staining

Bio/Physico-chemical Assay

Flow Cytometry

: Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Nov 11;58(11):2670-2684.e10. [Abstract]; Phosphorylcholine (PC, 10 μM; 24 h) increased HSV-1-induced cGAS-STING signaling and reduced HSV-1 replication in L929 cells.

: Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Nov 11;58(11):2670-2684.e10. [Abstract]; SMPDL3B (5 μM) were pre-incubated with Phosphorylcholine (PC, 100 μM) or ENPP1-1-IN-14 (100 μM) at 4°C for 30 min, and then incubated with cGAMP (100 μM) at 37°C for 3 h. The concentration of cGAMP was examined by cGAMP ELISA kit.

: Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Nov 11;58(11):2670-2684.e10. [Abstract]; SMPDL3B was pre-incubated with or without Phosphorylcholine (PC, 10 μM) at 4°C for 1 h, and then incubated with or without cGAMP (100 μM) at 37°C for 4 h. RAW-Lucia ISG cells were stimulated with the above reaction products (50-fold dilution) for 24 h and the ISRE reporter activity was assessed following the standard protocol.

: Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]; The pig intestines of the Phosphorylcholine (PC) (10 mg/kg; once daily for 8 days) pretreatment group exhibited mild congestion and edema in gut appearance, while the PEDV group showed obvious lesions and severe congestion and edema.

: Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]; Phosphorylcholine (PC) (10 mg/kg; once daily for 8 d) mitigated the negative impacts of intestinal virus, as evidenced by improved survival rates and body weight changes, and alleviated broken villi and extensive epithelial cell shedding in piglets.

: Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]; Phosphorylcholine (PC) (1, 5, and 10 μM; 24 h) treatment at different concentrations inhibited PEDV-induced cell death in both IPEC-J2 and Vero cells.

: Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]; Expression analysis of RIPK1, p-RIPK1, RIPK3, p-RIPK3, MLKL, p-MLKL, and PEDV-N in IPEC-J2 cells pre-treated with various Phosphorylcholine (PC) (1, 5, and 10 μM) concentrations post-PEDV infection. Phosphorylcholine (PC) (1, 5, and 10 μM) treatment reduced the phosphorylation levels of RIPK1, RIPK3, and MLKL.

: Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: Microbiome. 2025 Apr 2;13(1):90. [Abstract]; Phosphorylcholine (PC) (10 mg/kg; once daily for 8 days) pretreatment alleviated viral infection of the pig's intestines, keeping the intestinal villi and tissue structure intact, with only minor damage and epithelial cell shedding.

: Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2023 Sep 4;9(1):62. [Abstract]; Fecal water content and fecal Na⁺ content; C57BL/6 male mice were either orally administrated with 0.1 mL PBS (CONT group) or 0.1 mL Phosphorylcholine at a concentration of 2.5 mol/L (PC group) for 7 days. The results showed that that Phosphorylcholine increased fecal water and Na⁺ content.

: Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2023 Sep 4;9(1):62. [Abstract]; Colonic morphology (Scale bar = 200 μm; arrows, impaired villus). The results showed that Phosphorylcholine (Phosphocholine, 2.5 mol/L; 0.1 mL; i.g.; once daily for 7 days) protected mice from morphological damage.

: Calcium phosphorylcholine chloride, 98% purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2023 Sep 4;9(1):62. [Abstract]; Phosphorylcholine (Phosphocholine, 2.5 mol/L; 0.1 mL; i.g.; once daily for 7 days) alleviated C. rodentium-induced apoptosis, as indicated by decreased caspase-3 expression (Fig. n), and epithelial proliferation, as indicated by decreased Ki67 expression (Fig. o).

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Biological Activity
Purity & Documentation
Customer Review

Description

IC₅₀ & Target

Human Endogenous Metabolite

Microbial Metabolite

In Vitro

Calcium phosphorylcholine chloride, 98% is a component of drug delivery micelles, which improves the efficiency of cellular internalization and increases the cytotoxicity of cytotoxins carried in micelles in HeLa cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Calcium phosphorylcholine chloride, 98% (200-600 μmol/kg; ip; single dose) activates nicotinic and muscarinic cholinergic neurotransmission, stimulates the activation of α2-adrenergic receptors, and increases plasma glucagon and choline concentrations, thereby stimulating peripheral autonomic nervous system activity^[3].
Calcium phosphorylcholine chloride, 98% (2 μg; ip; once every two weeks for 4 months) induces the production of anti-PC and anti-oxLDL antibodies, increases mature B cells in the spleen, and reduces atherosclerotic lesions in the aortic root in mouse models^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

257.67

Formula

C₅H₁₃CaClNO₄P

CAS No.

4826-71-5

Appearance

Solid

Color

White to off-white

SMILES

O=P(OCC[N+](C)(C)C)([O-])[O-].[Ca+2].[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Solvent & Solubility

In Vitro:

H₂O : 87.5 mg/mL (339.58 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8809 mL	19.4047 mL	38.8093 mL
5 mM	0.7762 mL	3.8809 mL	7.7619 mL
10 mM	0.3881 mL	1.9405 mL	3.8809 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.95%

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Data Sheet (247 KB) SDS (419 KB)

COA (246 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.8809 mL	19.4047 mL	38.8093 mL	97.0233 mL
	5 mM	0.7762 mL	3.8809 mL	7.7619 mL	19.4047 mL
	10 mM	0.3881 mL	1.9405 mL	3.8809 mL	9.7023 mL
	15 mM	0.2587 mL	1.2936 mL	2.5873 mL	6.4682 mL
	20 mM	0.1940 mL	0.9702 mL	1.9405 mL	4.8512 mL
	25 mM	0.1552 mL	0.7762 mL	1.5524 mL	3.8809 mL
	30 mM	0.1294 mL	0.6468 mL	1.2936 mL	3.2341 mL
	40 mM	0.0970 mL	0.4851 mL	0.9702 mL	2.4256 mL
	50 mM	0.0776 mL	0.3881 mL	0.7762 mL	1.9405 mL
	60 mM	0.0647 mL	0.3234 mL	0.6468 mL	1.6171 mL
	80 mM	0.0485 mL	0.2426 mL	0.4851 mL	1.2128 mL
	100 mM	0.0388 mL	0.1940 mL	0.3881 mL	0.9702 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.