1. Acids and Aldehydes
  2. N-Hydroxypipecolic acid

N-Hydroxypipecolic acid (Synonyms: 1-Hydroxy-2-piperidinecarboxylic acid; NHP)

Cat. No.: HY-N7378 Purity: >98.0%
Handling Instructions

N-Hydroxypipecolic acid (1-Hydroxy-2-piperidinecarboxylic acid), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid induces SAR to bacterial and oomycete infection.

For research use only. We do not sell to patients.

N-Hydroxypipecolic acid Chemical Structure

N-Hydroxypipecolic acid Chemical Structure

CAS No. : 115819-92-6

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5 mg USD 105 In-stock
Estimated Time of Arrival: December 31
10 mg USD 185 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
250 mg USD 900 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

N-Hydroxypipecolic acid (1-Hydroxy-2-piperidinecarboxylic acid), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid induces SAR to bacterial and oomycete infection[1][2][3].

In Vitro

The mode of action of N-Hydroxypipecolic acid (NHP) in SAR involves direct induction of SAR gene expression, signal amplification, priming for enhanced defense activation and positive interplay with salicylic acid signaling to ensure elevated plant immunity. Flavin-dependent-monooxygenase1 (FMO1) functions downstream of Pip by hydroxylating Pip to generate NHP[1][3].

Clinical Trial
Molecular Weight

145.16

Formula

C₆H₁₁NO₃

CAS No.

115819-92-6

SMILES

O=C(C1N(O)CCCC1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (861.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.8889 mL 34.4447 mL 68.8895 mL
5 mM 1.3778 mL 6.8889 mL 13.7779 mL
10 mM 0.6889 mL 3.4445 mL 6.8889 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (14.33 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (14.33 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (14.33 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

N-Hydroxypipecolic acid1-Hydroxy-2-piperidinecarboxylic acidNHPOthersmetabolitesystemicresistanceimmunesignalfoliagepathogenattackbacterialInhibitorinhibitorinhibit

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N-Hydroxypipecolic acid
Cat. No.:
HY-N7378
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