Inosine oxime
Inosine oxime (6-Hydroxyadenosine) is an endogenous metabolite in the course of cell metabolism by cytochrome P450, by oxidative stress or by deviating nucleotide biosynthesis. Inosine oxime has toxic and mutagenic for procaryotic and eucaryotic cells.
For research use only. We do not sell to patients.
- CAS No.: 3414-62-8
- Formula: C10H13N5O5
- Molecular Weight:283.24
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | GI50 |
>100 μM
Compound: 1
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Antiproliferative activity against human Caco2 cells after 72 hrs by MTS assay
Antiproliferative activity against human Caco2 cells after 72 hrs by MTS assay
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[PMID: 21349610] |
| HeLa | GI50 |
3.4 μM
Compound: 1
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Antiproliferative activity against human HeLa cells after 72 hrs by MTS assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTS assay
|
[PMID: 21349610] |
| HT-29 | GI50 |
15 μM
Compound: 1
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Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
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[PMID: 21349610] |
| K562 | GI50 |
31 μM
Compound: 1
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Antiproliferative activity against human K562 cells after 72 hrs by MTS assay
Antiproliferative activity against human K562 cells after 72 hrs by MTS assay
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[PMID: 21349610] |
| KB | CC50 |
44.3 μM
Compound: 1a
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 17548196] |
| Leukemia cell | IC50 |
0.9 μM
Compound: 13
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Cytotoxicity against mouse leukemia cells
Cytotoxicity against mouse leukemia cells
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[PMID: 26314922] |
| MCF7 | GI50 |
>100 μM
Compound: 1
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Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
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[PMID: 21349610] |
Inosine oxime (6-Hydroxyadenosine) (1-5 nM) has reductive detoxication through direct dehydroxylamination catalyzed by adenosine deaminase to inosine and decreases inosine formation by 35% with knockdown of mARC1 in HEK-293.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3414-62-8
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Molecular Weight 283.24
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Formula C10H13N5O5
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SMILES
O[C@H]1[C@](O[C@@H]([C@H]1O)CO)([H])N2C3=C(/C(N=CN3)=N/O)N=C2
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Synonyms
6-Hydroxyadenosine
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Plitzko B, et, al. The pivotal role of the mitochondrial amidoxime reducing component 2 in protecting human cells against apoptotic effects of the base analog N6-hydroxylaminopurine. J Biol Chem. 2015 Apr 17;290(16):10126-35. [Content Brief]
[2]. Krompholz N, et, al. The mitochondrial Amidoxime Reducing Component (mARC) is involved in detoxification of N-hydroxylated base analogues. Chem Res Toxicol. 2012 Nov 19;25(11):2443-50. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Inosine oxime Related Classifications
HY-118793 Related Classifications
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