Cat. No.: HY-Y0399

L-Norvaline

(Synonyms: Norvaline)

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L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease.

For research use only. We do not sell to patients.

Purity: 98.0%
CAS No.: 6600-40-4
Formula: C₅H₁₁NO₂
Molecular Weight:117.15

Storage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

L-Norvaline Chemical Structure

CAS No.: 6600-40-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All TNF Receptor Isoforms :

In Vivo

L-Norvaline (250 mg/L, in drinking water for 2.5 months) reduces the amyloid-β deposition in the mouse hippocampus, reduces TNF-α expression, promotes the expression of PSD-95 protein, and ameliorates cognitive ability in 3 Tg-AD mouse models^[1].
L-Norvaline (20 mg/kg, every 3 days for 8 weeks, ip) exhibits antioxidant and anti-hyperglycemic effects in rats HFD and STZ (HY-13753) induced hyperglycemia models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

3 Tg-AD mouse models^[1]
Dosage:

250 mg/L
Administration:

drinking water for 2.5 months
Result:

Increased freezing time in the fear conditioning test.

Animal Model:

HFD and STZ (HY-13753) induced hyperglycemia rat models^[2]
Dosage:

20 mg/kg
Administration:

every 3 days for 8 weeks, ip
Result:

Decreased the level of blood glucose, lipids and malondialdehyde (MDA).

Chemical Information

CAS No. 6600-40-4
Appearance Solid
Molecular Weight 117.15
Formula C₅H₁₁NO₂
Color White to off-white
SMILES

N[C@@H](CCC)C(O)=O
Synonyms

Norvaline
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (426.80 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

8.5361 mL

42.6803 mL

85.3606 mL

5 mM

1.7072 mL

8.5361 mL

17.0721 mL

10 mM

0.8536 mL

4.2680 mL

8.5361 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 50 mg/mL (426.80 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Polis B, et al., L-Norvaline, a new therapeutic agent against Alzheimer's disease. Neural Regen Res. 2019 Sep;14(9):1562-1572. [Content Brief]

[2]. Javrushyan H, et al., Antihyperglycemic activity of L-norvaline and L-arginine in high-fat diet and streptozotocin-treated male rats. Exp Mol Pathol. 2022 Jun;126:104763. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	8.5361 mL	42.6803 mL	85.3606 mL	213.4016 mL
	5 mM	1.7072 mL	8.5361 mL	17.0721 mL	42.6803 mL
	10 mM	0.8536 mL	4.2680 mL	8.5361 mL	21.3402 mL
	15 mM	0.5691 mL	2.8454 mL	5.6907 mL	14.2268 mL
	20 mM	0.4268 mL	2.1340 mL	4.2680 mL	10.6701 mL
	25 mM	0.3414 mL	1.7072 mL	3.4144 mL	8.5361 mL
	30 mM	0.2845 mL	1.4227 mL	2.8454 mL	7.1134 mL
	40 mM	0.2134 mL	1.0670 mL	2.1340 mL	5.3350 mL
	50 mM	0.1707 mL	0.8536 mL	1.7072 mL	4.2680 mL
	60 mM	0.1423 mL	0.7113 mL	1.4227 mL	3.5567 mL
	80 mM	0.1067 mL	0.5335 mL	1.0670 mL	2.6675 mL
	100 mM	0.0854 mL	0.4268 mL	0.8536 mL	2.1340 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Norvaline

Apoptosis Compound Library

Immunology/Inflammation Compound Library

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All TNF Receptor Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

L-Norvaline Related Classifications

HY-Y0399 Related Classifications