Apovincaminic acid hydrochloride salt

Name: Apovincaminic acid hydrochloride salt
Brand: MedChemExpress
SKU: HY-133813A
Rating: 4.5 (1 reviews)

Cat. No.: HY-133813A Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action.

For research use only. We do not sell to patients.

Apovincaminic acid hydrochloride salt Chemical Structure

CAS No. : 72296-47-0

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 121	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 121	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 175	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

Apovincaminic acid (10 mg/kg; i.p. twice daily for 4 days) effectively attenuates the behavioral deficits, and significantly decreases lesion size and the region of microglia activation^[1].
Apovincaminic acid (10 mg/kg; p.o.) is absorbed 50% of the dose comparing with i.v. administration in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Harlan‐Wistar rats (300-400 g) are injected NMDA^[1]
Dosage:	10 mg/kg
Administration:	I.p. twice daily for 4 days
Result:	Attenuated the attention deficit effectively. Prevented the learning and memory impairment in the spontaneous alternation and Morris water maze tests. significantly reduced lesion size microglia activation.

Molecular Weight

358.86

Formula

C₂₀H₂₃ClN₂O₂

CAS No.

72296-47-0

Appearance

Solid

Color

Off-white to yellow

SMILES

CC[C@@]12[C@@]3([H])C4=C(CCN3CCC2)C5=CC=CC=C5N4C(C(O)=O)=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (139.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7866 mL	13.9330 mL	27.8660 mL
5 mM	0.5573 mL	2.7866 mL	5.5732 mL
10 mM	0.2787 mL	1.3933 mL	2.7866 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (283 KB) SDS (251 KB)

COA (264 KB) Elemental Analysis Report (121 KB)

Handling Instructions (2659 KB)

References

[1]. Nyakas C, et, al. Neuroprotective effects of vinpocetine and its major metabolite cis-apovincaminic acid on NMDA-induced neurotoxicity in a rat entorhinal cortex lesion model. CNS Neurosci Ther. Summer 2009;15(2):89-99. [Content Brief]

[2]. Pudleiner P, et, al. Study on the absorption of vinpocetine and apovincaminic acid. Eur J Drug Metab Pharmacokinet. Oct-Dec 1993;18(4):317-21. [Content Brief]

[3]. Wang M, et, al. Simultaneous Determination of Vinpocetine and its Major Active Metabolite Apovincaminic Acid in Rats by UPLC-MS/MS and its Application to the Brain Tissue Distribution Study. J Chromatogr Sci. 2018 Mar 1;56(3):225-232. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7866 mL	13.9330 mL	27.8660 mL	69.6651 mL
	5 mM	0.5573 mL	2.7866 mL	5.5732 mL	13.9330 mL
	10 mM	0.2787 mL	1.3933 mL	2.7866 mL	6.9665 mL
	15 mM	0.1858 mL	0.9289 mL	1.8577 mL	4.6443 mL
	20 mM	0.1393 mL	0.6967 mL	1.3933 mL	3.4833 mL
	25 mM	0.1115 mL	0.5573 mL	1.1146 mL	2.7866 mL
	30 mM	0.0929 mL	0.4644 mL	0.9289 mL	2.3222 mL
	40 mM	0.0697 mL	0.3483 mL	0.6967 mL	1.7416 mL
	50 mM	0.0557 mL	0.2787 mL	0.5573 mL	1.3933 mL
	60 mM	0.0464 mL	0.2322 mL	0.4644 mL	1.1611 mL
	80 mM	0.0348 mL	0.1742 mL	0.3483 mL	0.8708 mL
	100 mM	0.0279 mL	0.1393 mL	0.2787 mL	0.6967 mL