Apovincaminic acid hydrochloride salt
Based on 1 publication(s) in Google Scholar
Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action.
For research use only. We do not sell to patients.
- Purity: 96.93%
- CAS No.: 72296-47-0
- Formula: C20H23ClN2O2
- Molecular Weight:358.86
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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CNS-Penetrant Compound Library
HY-L028
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Orally Active Compound Library
HY-L061
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Neuroprotective Compound Library
HY-L070
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Drug Metabolite Library
HY-L098
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) Apovincaminic acid hydrochloride salt
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Biological Activity
Apovincaminic acid (10 mg/kg; p.o.) is absorbed 50% of the dose comparing with i.v. administration in rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Harlan‐Wistar rats (300-400 g) are injected NMDA[1]
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Dosage:10 mg/kg
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Administration:I.p. twice daily for 4 days
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Result:Attenuated the attention deficit effectively.
Prevented the learning and memory impairment in the spontaneous alternation and Morris water maze tests.
significantly reduced lesion size microglia activation.
Chemical Information
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CAS No. 72296-47-0
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Appearance Solid
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Molecular Weight 358.86
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Formula C20H23ClN2O2
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Color Off-white to yellow
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SMILES
CC[C@@]12[C@@]3([H])C4=C(CCN3CCC2)C5=CC=CC=C5N4C(C(O)=O)=C1.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Birth Defects Res
Developmental Toxicity Evaluation of the Dietary Supplement Vinpocetine Using Mouse and Human 3D Gastruloids. [Abstract]2026 May;118(5):e70060. PMID: 42167926
Solvent & Solubility
DMSO : 50 mg/mL (139.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Nyakas C, et, al. Neuroprotective effects of vinpocetine and its major metabolite cis-apovincaminic acid on NMDA-induced neurotoxicity in a rat entorhinal cortex lesion model. CNS Neurosci Ther. Summer 2009;15(2):89-99. [Content Brief]
[2]. Pudleiner P, et, al. Study on the absorption of vinpocetine and apovincaminic acid. Eur J Drug Metab Pharmacokinet. Oct-Dec 1993;18(4):317-21. [Content Brief]
[3]. Wang M, et, al. Simultaneous Determination of Vinpocetine and its Major Active Metabolite Apovincaminic Acid in Rats by UPLC-MS/MS and its Application to the Brain Tissue Distribution Study. J Chromatogr Sci. 2018 Mar 1;56(3):225-232. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7866 mL | 13.9330 mL | 27.8660 mL | 69.6651 mL |
| 5 mM | 0.5573 mL | 2.7866 mL | 5.5732 mL | 13.9330 mL | |
| 10 mM | 0.2787 mL | 1.3933 mL | 2.7866 mL | 6.9665 mL | |
| 15 mM | 0.1858 mL | 0.9289 mL | 1.8577 mL | 4.6443 mL | |
| 20 mM | 0.1393 mL | 0.6967 mL | 1.3933 mL | 3.4833 mL | |
| 25 mM | 0.1115 mL | 0.5573 mL | 1.1146 mL | 2.7866 mL | |
| 30 mM | 0.0929 mL | 0.4644 mL | 0.9289 mL | 2.3222 mL | |
| 40 mM | 0.0697 mL | 0.3483 mL | 0.6967 mL | 1.7416 mL | |
| 50 mM | 0.0557 mL | 0.2787 mL | 0.5573 mL | 1.3933 mL | |
| 60 mM | 0.0464 mL | 0.2322 mL | 0.4644 mL | 1.1611 mL | |
| 80 mM | 0.0348 mL | 0.1742 mL | 0.3483 mL | 0.8708 mL | |
| 100 mM | 0.0279 mL | 0.1393 mL | 0.2787 mL | 0.6967 mL |
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