Apovincaminic acid hydrochloride salt
Based on 1 publication(s) in Google Scholar
Apovincaminic acid hydrochloride salt is the major metabolite of Vinpocetine (HY-13295), with blood-brain barrier permeability and oral activity. Apovincaminic acid hydrochloride salt is detectable in the plasma of pregnant rabbits after oral administration of Vinpocetine. Apovincaminic acid hydrochloride salt is absorbable from all segments of the gastrointestinal tract of Norway rat, with the stomach as the primary absorption site, and is excreted via urine and feces. Apovincaminic acid hydrochloride salt is used in the research of cerebrovascular diseases.
For research use only. We do not sell to patients.
- Purity: 96.93%
- CAS No.: 72296-47-0
- Formula: C20H23ClN2O2
- Molecular Weight:358.86
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Apovincaminic acid hydrochloride salt
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Biological Activity
Description
In Vitro
Apovincaminic acid hydrochloride salt is the major metabolite of Vinpocetine (HY-13295), a vinca alkaloid derivative that blocks Na+ channels. Vinpocetine inhibits IKK with an IC50 value of 17.17 μM. Vinpocetine also acts as a PDE inhibitor and suppresses NF-κB-dependent inflammatory responses by directly targeting IKK[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Apovincaminic acid (0.148 μCi, 10 mg/kg; direct injection into ligated gastrointestinal segments, i.v., p.o.; 1 hour, 72 hours) hydrochloride salt is absorbed from all tested segments of the Rattus norvegicus gastrointestinal tract (with notable uptake in stomach and jejunum walls), with approximately 50% of an oral dose absorbed, and is excreted primarily in urine after i.v. administration and in faeces after oral administration[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:RG-Wistar (male, 180-210 g)[2]
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Dosage:0.148 μCi (in situ study); 10 mg/kg (excretion study)
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Administration:direct injection into ligated gastrointestinal segments; 1 hour (in situ study); i.v., p.o.; 72 hours (excretion study)
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Result:Absorbed Apovincaminic acid from all tested gastrointestinal segments.
Retained most drug dose in stomach, duodenum and jejunum lumen and wall 1 h after oral intake.
Recovered total 79.26% radioactive substance in urine and feces within 72 h post intravenous injection.
Recovered total 80.19% radioactive substance in urine and feces within 72 h post oral administration.
Revealed about 50% absorption rate for oral dosage form.
Detected original apovincaminic acid in urine under both administration modes.
Chemical Information
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CAS No. 72296-47-0
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Appearance Solid
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Molecular Weight 358.86
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Formula C20H23ClN2O2
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Color Off-white to yellow
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SMILES
CC[C@@]12[C@@]3([H])C4=C(CCN3CCC2)C5=CC=CC=C5N4C(C(O)=O)=C1.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Birth Defects Res
Developmental Toxicity Evaluation of the Dietary Supplement Vinpocetine Using Mouse and Human 3D Gastruloids. [Abstract]2026 May;118(5):e70060. PMID: 42167926
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (139.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (285 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Catlin N, et al. Embryo-fetal development studies with the dietary supplement vinpocetine in the rat and rabbit. Birth defects research. 2018 Jun 01;110(10):883-896. [Content Brief]
[2]. Pudleiner P, et al. Study on the absorption of vinpocetine and apovincaminic acid. European journal of drug metabolism and pharmacokinetics. 1993;18(4):317-21. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7866 mL | 13.9330 mL | 27.8660 mL | 69.6651 mL |
| 5 mM | 0.5573 mL | 2.7866 mL | 5.5732 mL | 13.9330 mL | |
| 10 mM | 0.2787 mL | 1.3933 mL | 2.7866 mL | 6.9665 mL | |
| 15 mM | 0.1858 mL | 0.9289 mL | 1.8577 mL | 4.6443 mL | |
| 20 mM | 0.1393 mL | 0.6967 mL | 1.3933 mL | 3.4833 mL | |
| 25 mM | 0.1115 mL | 0.5573 mL | 1.1146 mL | 2.7866 mL | |
| 30 mM | 0.0929 mL | 0.4644 mL | 0.9289 mL | 2.3222 mL | |
| 40 mM | 0.0697 mL | 0.3483 mL | 0.6967 mL | 1.7416 mL | |
| 50 mM | 0.0557 mL | 0.2787 mL | 0.5573 mL | 1.3933 mL | |
| 60 mM | 0.0464 mL | 0.2322 mL | 0.4644 mL | 1.1611 mL | |
| 80 mM | 0.0348 mL | 0.1742 mL | 0.3483 mL | 0.8708 mL | |
| 100 mM | 0.0279 mL | 0.1393 mL | 0.2787 mL | 0.6967 mL |
Apovincaminic acid hydrochloride salt Related Classifications
HY-133813A Related Classifications
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