1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. Apovincaminic acid hydrochloride salt

Apovincaminic acid hydrochloride salt 

Cat. No.: HY-133813A Purity: >98.0%
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Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action.

For research use only. We do not sell to patients.

Apovincaminic acid hydrochloride salt Chemical Structure

Apovincaminic acid hydrochloride salt Chemical Structure

CAS No. : 72296-47-0

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5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action[1][2].

In Vivo

Apovincaminic acid (10 mg/kg; i.p. twice daily for 4 days) effectively attenuates the behavioral deficits, and significantly decreases lesion size and the region of microglia activation[1].
Apovincaminic acid (10 mg/kg; p.o.) is absorbed 50% of the dose comparing with i.v. administration in rats[2].

Animal Model: Male Harlan‐Wistar rats (300-400 g) are injected NMDA[1]
Dosage: 10 mg/kg
Administration: I.p. twice daily for 4 days
Result: Attenuated the attention deficit effectively.
Prevented the learning and memory impairment in the spontaneous alternation and Morris water maze tests.
significantly reduced lesion size microglia activation.
Molecular Weight

358.86

Formula

C₂₀H₂₃ClN₂O₂

CAS No.

72296-47-0

SMILES

CC[[email protected]@]12[[email protected]@]3([H])C4=C(CCN3CCC2)C5=CC=CC=C5N4C(C(O)=O)=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

Apovincaminic acidDrug MetabolitemetaboliteVinpocetineVPneuroprotectiveInhibitorinhibitorinhibit

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Apovincaminic acid hydrochloride salt
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HY-133813A
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