1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Phosphoribosyl pyrophosphate pentasodium

Phosphoribosyl pyrophosphate pentasodium (Synonyms: PRPP pentasodium)

Cat. No.: HY-W013046
Handling Instructions

Phosphoribosyl pyrophosphate (PRPP) pentasodium is an important metabolite required in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, and the cofactors NAD and NADP.

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Phosphoribosyl pyrophosphate pentasodium Chemical Structure

Phosphoribosyl pyrophosphate pentasodium Chemical Structure

CAS No. : 108321-05-7

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5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
25 mg USD 490 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Phosphoribosyl pyrophosphate (PRPP) pentasodium is an important metabolite required in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, and the cofactors NAD and NADP[1].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

Phosphoribosyl diphosphate (PRPP) pentasodium is an important intermediate in cellular metabolism. PRPP is synthesized by PRPP synthase, as follows: ribose 5-phosphate + ATP → PRPP + AMP. PRPP is ubiquitously found in living organisms and is used in substitution reactions with the formation of glycosidic bonds. PRPP is utilized in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, the cofactors NAD and tetrahydromethanopterin, arabinosyl monophosphodecaprenol, and certain aminoglycoside antibiotics[1].
Phosphoribosyl diphosphate (5-Phosphoribosyl-l-pyrophosphate) pentasodium, a substrate shared by adenine phosphoribosyltransferase and hypoxanthine-guanine phosphoribosyltransferase, accumulates in human erythrocytes lacking hypoxanthine-guanine phosphoribosyltransferase. 5-Phosphoribosyl-l-pyrophosphate added to purified adenine phosphoribosyltransferase stabilizes it against heat inactivation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

499.98

Formula

C₅H₈Na₅O₁₄P₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (250.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0001 mL 10.0004 mL 20.0008 mL
5 mM 0.4000 mL 2.0001 mL 4.0002 mL
10 mM 0.2000 mL 1.0000 mL 2.0001 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Phosphoribosyl pyrophosphate pentasodium
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HY-W013046
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